Protein Alignment Ube3a and Ube3b

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001137366.1
• Gene: Ube3b / 687633
• RGDID: 1583074
• Length: 1070
• Species: Rattus norvegicus
• Alignment Length: 965
• Identity: 218/965 - (22%)
• Similarity: 362/965 - (37%)
• Gaps: 290/965 - (30%)

  Fly   177 PC--TPTLAPVHSLDANSLIALYEQCRAADSYDR--ICHAIGVVFSSVDRLGKSFIRSAEPAASS 237
            ||  ..||....:|....::|    .:.:||..|  |.|.:.|                 ||..:
  Rat   222 PCLSKSTLTAAFTLALRPVVA----AQFSDSLMRPFIIHIMSV-----------------PALVA 265

  Fly   238 SLQELLANSPGALNKEQLRTLEGEHD---------KDEDSTQQVDEQSESAANATATAESVESEA 293
            .|..:   :|     |:|..|| .||         :|.|..|
  Rat   266 HLSTM---AP-----ERLGVLE-SHDMLRKFIVFLRDRDRCQ----------------------- 298

  Fly   294 EPEEEDDDVCSS-QSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMR------ 351
                   |.|.| :...||..:..|..:..|    .::.:.|:....|..|:..:.|.:
  Rat   299 -------DACESLEGCHTLCLMGNLLHLGSL----NLKMLEEETDGFVSLLTQMLCYCQKYVSQK 352

  Fly   352 ----TDWERVIHCLVICFDLATNTNNSVV--DMDYL-----------DRVLPKLCQAASAMPVPA 399
                |.|..|:.......|...|.:..::  .:.:|           |.:..||.:...  ||||
  Rat   353 KSNLTHWHPVLGWFSQSVDYGLNDSMYLITKQLQFLWGVPLIRIFFSDILSKKLLEPPE--PVPA 415

  Fly   400 QARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESM--RENESIISVTKVLKIVFYANILASE 462
            |                      .|..:.|.:|..:|:  |..:...||..:||.|....:.::|
  Rat   416 Q----------------------PQPSSPQTVLPVKSLLKRAFQKSASVRNILKPVGGRRVDSTE 458

  Fly   463 LERPSCRVPLEDRTEAAT--------ASGSAAVED---DLFVYNSLLEPH--MPKFAE----DQF 510
            : |..|.:.:..:|...|        .:|...::|   .|:.:...|.||  :..|.|    |..
  Rat   459 V-RKVCSICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTG 522

  Fly   511 EKELQVSAI----DCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIG-SGHANYFSFML 570
            |.:..::.:    ||.:.||        .:.::|:::.:.:|:|   :|..:. |...|.|.|.:
  Rat   523 ESKQLLAMLMLFCDCSRHLI--------TILDDIEVYEEQISFK---LEELVTISSFLNSFVFKM 576

  Fly   571 YAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNI------GQVGQEDN-PRPDLK------- 621
            ....:..:.|.:.|          |.:.|:|..|..:      .:...||: .|.|||
  Rat   577 IWDGIVENAKGETL----------ELFQSVHGWLMVLYERDCRRRFAPEDHWLRKDLKPGVLFQE 631

  Fly   622 -----------------------------------------------------LTVRRDQLINDA 633
                                                                 :|:||.:::.|
  Rat   632 LDKDRKRAQLILLHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLED- 695

  Fly   634 LIGLEMVAMSNPKDLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEET 693
              |.|.:.......:|..:.|:||.     |.|||:.||.|||.:.|::.:|:||..:|......
  Rat   696 --GYEQLRQLPQHAMKGAIRVKFVSDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGD 758

  Fly   694 NNMWFNATPF--ENGAQ-FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIG-YCGTFADLSDWSPA 754
            ..::.:.|.:  ||..| |..:|.::|.|:|..:.:.|.|......:::| :...|....|..|:
  Rat   759 ERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPS 823

  Fly   755 L----YKSLKSMLDYQGQDMEEVFEQTFKISY-SDVFGDVVQHELVPNGQDVLVGQHNKELFVNL 814
            |    ||:|.|:..|.|    :|.:....:|| .||.|.:|.|||||.|:.:.|...||..:::|
  Rat   824 LDSEFYKNLTSIKRYDG----DVADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHL 884

  Fly   815 YSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG-SREFDFVELENSTVYEGGY 878
            .:.|.::|.|:.|..|...||..:.....:::...| |::.|:.| :.|.|..:|:..|||.||:
  Rat   885 MAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTP-ELQRLISGDNAEIDLEDLKKHTVYYGGF 948

  Fly   879 TEKSQYIQDFWSIVHA--MPSEDKHKLLEFTTGSARVPVGG---------LKC------------ 920
            ....:.|...|.|:.:  .|.| :...|:|.|..:|.|:.|         ::|
  Rat   949 HGSHRVIVWLWDILASDFTPGE-RAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDT 1012

  Fly   921 ----LRLLIT-RHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
                ||...| |......|||||.||||:|.||.||.:..|.|:|..||:.:.||
  Rat  1013 LGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173
		HECTc	620..971	CDD:238033	121/454 (27%)
Ube3b	NP_001137366.1	HECTc	684..1068	CDD:238033	119/393 (30%)