Protein Alignment Ube3a and Arel1

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001351118.1
• Gene: Arel1 / 68497
• MGIID: 1915747
• Length: 823
• Species: Mus musculus
• Alignment Length: 702
• Identity: 160/702 - (22%)
• Similarity: 287/702 - (40%)
• Gaps: 163/702 - (23%)

  Fly   395 MPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEE---------SMRENESIISVTKVL 450
            |.||::.::    ..|.|    :|:..|.|..|||::..:|         |:|:..|.......|
Mouse   162 MVVPSKTKI----VCHFS----TLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHSYSLAIHEL 218

  Fly   451 --------KIVFYANILASELERPSC----RVPLEDR---------------------------- 475
                    ::.|..::.::   |.:|    |:.|..|
Mouse   219 GPQEEENNEVSFEKSVTSN---RQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSENE 280

  Fly   476 ---TEAATASGSAAVEDDLFVYNS---LLEP-HMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYN 533
               .|...::...::..:.::||:   ...| |:|         .:.:|:.. |:|...:||...
Mouse   281 KNIVERNVSTSGVSIYFEAYLYNANNCTSTPWHLP---------PMHMSSSQ-RRPSTAIEEDDE 335

  Fly   534 EALSENIQMH-----------HDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYD 587
            ::.||   .|           :.|:|.|..:::    ..:.....:.||.|.:.|.||...|..|
Mouse   336 DSPSE---CHTPEKVKKPKKVYCYVSPKQFSVK----EFYLKIIPWRLYTFRVCPGTKFSYLGPD 393

  Fly   588 SRMRMYS----------------ER----YSSLHSILNNIG--------------QVGQEDNPRP 618
            ...::.:                ||    .:.:.|:..|||              ::.|....||
Mouse   394 PVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRP 458

  Fly   619 DLKLT--VRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFN 681
            ..|:|  |.|..|:..:|......::|   |..|...|.|..|:.:|.||..:|:|:||.:.:|:
Mouse   459 HSKVTLKVSRHALLESSLKATRNFSIS---DWSKNFEVVFQDEEALDWGGPRREWFELICKALFD 520

  Fly   682 PAFGMFIQQEETNNMWFNATPFENG----AQFTLIGIIIGLAIYNN-------VTLAVNFPMVVY 735
            ....:|.:..::|....:..|....    ..:...|.::|..:|.:       ..:...|.....
Mouse   521 TTSQLFARFTDSNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFL 585

  Fly   736 RKLIGYCGTFADLSDWSPALYKS-LKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQ 799
            .::||....:.......|..||| :..:|:....:||.||.:. |.:.|.....:|  ||:..|.
Mouse   586 AQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEE-KYNKSGQLDKIV--ELMTGGA 647

  Fly   800 DVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFD 864
            ...|...||..::||.:.:.|.:.::::...|.||...:..|: |..:|...|:|:|:||:.:.:
Mouse   648 QTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPEN-LLAIFDENELELLMCGTGDIN 711

  Fly   865 FVELENSTVYEGG---YTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL----R 922
            ..:.:...|..||   :.||  .::.||::|.::..|:..:||:|||||:::|.||...|    :
Mouse   712 VSDFKAHAVVVGGSWHFREK--VMRWFWAVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQ 774

  Fly   923 LLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYS-KGFGML 973
            ::.   .|....|||:|||||.|.||.|.|.|::...|..||:.. :|||||
Mouse   775 IIA---APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	100/372 (27%)
		HECTc	647..970	CDD:214523	92/342 (27%)
Arel1	NP_001351118.1	Filamin	56..154	CDD:395505
		Filamin	64..158
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..345		9/42 (21%)
		HECTc	464..821	CDD:238033	98/368 (27%)
		Interaction with SOCS2. /evidence=ECO:0000250|UniProtKB:O15033	483..789		79/317 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900