Protein Alignment Ube3a and Wwp2

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_080106.1
• Gene: Wwp2 / 66894
• MGIID: 1914144
• Length: 870
• Species: Mus musculus
• Alignment Length: 989
• Identity: 226/989 - (22%)
• Similarity: 363/989 - (36%)
• Gaps: 275/989 - (27%)

  Fly    49 HQLQS---GCGNANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDML 110
            |.|::   |..:.|.||....:.||:                             .|:...:::.
Mouse    89 HTLRNELLGTASVNLSNVLKNNGGKM-----------------------------ENTQLTLNLQ 124

  Fly   111 SPNDSSSSSSGSST----------------STITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQS 159
            :.|..|..|.|..|                |.:|..|  ...||:|..|..|       |.....
Mouse   125 TENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDGS--QPPSRESSGTAIA-------PETRHQ 180

  Fly   160 VPQLDIAGA-----EHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSS 219
            .|..:..|.     .||.|.:...|               |..||...|.:
Mouse   181 PPSTNCFGGRSRTHRHSGGSARTAT---------------AASEQSPGARN-------------- 216

  Fly   220 VDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATA 284
                     |..:|..:|| ...|||  |.:|:|.....|.|    |.|...|.....:|.:.::
Mouse   217 ---------RHRQPVKNSS-SSGLAN--GTVNEEPTPASEPE----ESSVVGVTSLPAAALSVSS 265

  Fly   285 --TAESVESEAEPEE-EDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDW 346
              ...|:.:::.|.| |:.....:|........|     ..|..|.:.|           :|.:.
Mouse   266 NPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAP-----DALPAGWEQR-----------ELPNG 314

  Fly   347 VIY------MRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLAR 405
            .:|      ..|.|||.   |...::..|:.......:|:..|.      .....|.....|...
Mouse   315 RVYYVDHNTKTTTWERP---LPPGWEKRTDPRGRFYYVDHNTRT------TTWQRPTAEYVRNYE 370

  Fly   406 IWAAHCSDQLHSLIAACQQQITLQ---VLLDE----------ESMRENESIISVTKVLKIVFYAN 457
            .|.:. .:||...:....|:...|   ...|.          |..::|..:..|..        |
Mouse   371 QWQSQ-RNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNH--------N 426

  Fly   458 ILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCR 522
            ...::.|.|        ||:                 ..:.||.:|...|.::
Mouse   427 TRTTQWEDP--------RTQ-----------------GMIQEPALPPGWEMKY------------ 454

  Fly   523 KPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIG--SGHANYFSFMLYAFILTPSTKVDALY 585
                         .||.::...|:.:..|...:...|  ||              |......|
Mouse   455 -------------TSEGVRYFVDHNTRTTTFKDPRPGFESG--------------TKQGSPGA-- 490

  Fly   586 YDSRMRMYSERYSSL-HSILNNIGQVGQEDNPRPD-LKLTVRRDQLINDALIGLEMVAMSNPKDL 648
            ||...|....::..| ||            |..|. :|::|.|..|..|:   .:.:....|.||
Mouse   491 YDRSFRWKYHQFRFLCHS------------NALPSHVKISVSRQTLFEDS---FQQIMNMKPYDL 540

  Fly   649 KKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF-----ENGAQ 708
            :::|.:...||:|:|.||:::|:|.|:..|:.||.:.:| :....||......|.     ::...
Mouse   541 RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLF-EYAGKNNYCLQINPASSINPDHLTY 604

  Fly   709 FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV 773
            |..||..|.:|:|:...:...|.:..|::::....|..||....|..|.|:..:.:   .::||.
Mouse   605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE---NNLEEC 666

  Fly   774 FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMV 838
            ..:.|.|...::.|.|..|||...|:::.|.:.|||.::.|.:|:.....:|:|..||..||..|
Mouse   667 GLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731

  Fly   839 TDESPLKLL--FRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKH 901
               :||:.|  |..:|:|:::||.:|.|..:.:.:.:|. .||:.|:.||.||.:|..|.:|.:.
Mouse   732 ---APLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYR-HYTKSSKQIQWFWQVVKEMDNEKRI 792

  Fly   902 KLLEFTTGSARVPVGGLKCLRLLITRHGPDS---DR------LPTSHTCFNVLLLPEYSSREKLE 957
            :||:|.||:.|:||||   ...||..:||..   ||      ||.||||||.|.||.|.|.|:|:
Mouse   793 RLLQFVTGTCRLPVGG---FAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLK 854

  Fly   958 ERLMKAINYSKGFG 971
            |:|:.||..::|||
Mouse   855 EKLLYAIEETEGFG 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	8/47 (17%)
		HECTc	620..971	CDD:238033	119/366 (33%)
		HECTc	647..970	CDD:214523	112/338 (33%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	14/81 (17%)
		PRK07003	<149..>299	CDD:235906	40/203 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..300		41/208 (20%)
		WW	302..331	CDD:366073	8/39 (21%)
		WW	332..361	CDD:366073	4/34 (12%)
		WW	407..435	CDD:366073	5/35 (14%)
		WW	447..477	CDD:238122	6/54 (11%)
		HECTc	516..868	CDD:238033	119/365 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810