DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Smurf2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_079757.2	Gene:	Smurf2 / 66313	MGIID:	1913563	Length:	748	Species:	Mus musculus

Alignment Length:	522	Identity:	142/522 - (27%)
Similarity:	245/522 - (46%)	Gaps:	100/522 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 QMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRM--------------- 590
            |.|.:|:|...|....::..|:....:.....:.|...|.| :.::|.|:
Mouse   236 QRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGV-STWHDPRVPRDLSNINCEELGPL 299

  Fly   591 ------------RMY------------SERYS-SLHSILNNIGQVGQEDNPR-----PD------ 619
                        |:|            ..|.| :||.:||...|:..:...:     ||
Mouse   300 PPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTECLT 364

  Fly   620 ----------------------------LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEF 656
                                        .::.|.|:::..::   ...|....||||.|:|:::|
Mouse   365 VPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEES---YRQVMKMRPKDLWKRLMIKF 426

  Fly   657 VGEQGIDEGGVSKEFFQLIVEEIFNPAFGMF-IQQEETNNMWFN---ATPFENGAQFTLIGIIIG 717
            .||:|:|.|||::|:..|:..|:.||.:|:| ..:::...:..|   |...|:.:.|..:|.|:|
Mouse   427 RGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMG 491

  Fly   718 LAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISY 782
            :|:::...:...|.:..|::|:|...|..|:....|.|:.||..:|:   .|:..|.:.||.:.:
Mouse   492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE---NDITGVLDHTFCVEH 553

  Fly   783 SDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLL 847
             :.:|:::||||.|||:.:.|.:.||:.:|.||.::.....||.||.|.:|||..|..:..|| .
Mouse   554 -NAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK-T 616

  Fly   848 FRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSAR 912
            |..:|:|:::||..:.|..:.:.:|..: ..|..|..::.||..|.....|.:.:||:|.|||:|
Mouse   617 FDEKELELIICGLGKIDVSDWKVNTRLK-HCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSR 680

  Fly   913 VPVGGLKCLR-----LLITRHGPD--SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            ||:.|.|.|:     .|.|.|..|  ::.||.:|||||.:.:|.|.|.|||.|:|:.||..:.||
Mouse   681 VPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

  Fly   971 GM 972
            .:
Mouse   746 AV 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	119/361 (33%)
		HECTc	647..970	CDD:214523	113/333 (34%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736	5/31 (16%)
		WW	298..330	CDD:197736	2/31 (6%)
		HECTc	393..745	CDD:238033	118/360 (33%)
		HECTc	420..745	CDD:214523	111/330 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810