DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and SMURF2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_073576.1	Gene:	SMURF2 / 64750	HGNCID:	16809	Length:	748	Species:	Homo sapiens

Alignment Length:	522	Identity:	142/522 - (27%)
Similarity:	245/522 - (46%)	Gaps:	100/522 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 QMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRM--------------- 590
            |.|.:|:|...|....::..|:....:.....:.|...|.| :.::|.|:
Human   236 QRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGV-STWHDPRVPRDLSNINCEELGPL 299

  Fly   591 ------------RMY------------SERYS-SLHSILNNIGQVGQEDNPR-----PD------ 619
                        |:|            ..|.| :||.:||...|:..:...:     ||
Human   300 PPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLT 364

  Fly   620 ----------------------------LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEF 656
                                        .::.|.|:::..::   ...|....||||.|:|:::|
Human   365 VPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEES---YRQVMKMRPKDLWKRLMIKF 426

  Fly   657 VGEQGIDEGGVSKEFFQLIVEEIFNPAFGMF-IQQEETNNMWFN---ATPFENGAQFTLIGIIIG 717
            .||:|:|.|||::|:..|:..|:.||.:|:| ..:::...:..|   |...|:.:.|..:|.|:|
Human   427 RGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMG 491

  Fly   718 LAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISY 782
            :|:::...:...|.:..|::|:|...|..|:....|.|:.||..:|:   .|:..|.:.||.:.:
Human   492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE---NDITGVLDHTFCVEH 553

  Fly   783 SDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLL 847
             :.:|:::||||.|||:.:.|.:.||:.:|.||.::.....||.||.|.:|||..|..:..|| .
Human   554 -NAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK-T 616

  Fly   848 FRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSAR 912
            |..:|:|:::||..:.|..:.:.:|..: ..|..|..::.||..|.....|.:.:||:|.|||:|
Human   617 FDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSR 680

  Fly   913 VPVGGLKCLR-----LLITRHGPD--SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            ||:.|.|.|:     .|.|.|..|  ::.||.:|||||.:.:|.|.|.|||.|:|:.||..:.||
Human   681 VPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

  Fly   971 GM 972
            .:
Human   746 AV 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	119/361 (33%)
		HECTc	647..970	CDD:214523	113/333 (34%)
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028
SMURF2	NP_073576.1	HUL4	<159..745	CDD:227354	140/518 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810