DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ube3a and Huwe1

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:XP_006528996.1 Gene:Huwe1 / 59026 MGIID:1926884 Length:4456 Species:Mus musculus


Alignment Length:1182 Identity:260/1182 - (21%)
Similarity:444/1182 - (37%) Gaps:325/1182 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GGGGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLI------------------------ 44
            ||....::|     ::|||.. .:..:|.|.:.|..:.:||                        
Mouse  3386 GGRKHTEKH-----ASSGSTV-HIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDR 3444

  Fly    45 KRYFHQLQSGCGNANCSNANC---------------------------ASSGKVAPMTPNEVAAR 82
            :|...|..|.|.:.:.|:..|                           .|||.....:|:.:.|.
Mouse  3445 ERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSSGGEGETSPHSLEAS 3509

  Fly    83 AL-QLFS--------QDAQLCE------AFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSAST 132
            .| ||.:        :.:.|.|      :..|.|.....|..:..|.|:|.||.::||..::.:|
Mouse  3510 PLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEVQTNSSNSGSSTAATSNTSTTTT 3574

  Fly   133 TTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHS---SGDSEPCTPTLAPV--------- 185
            ||||:.....||.|...||:      |.|.|..|.|..:   :..:...|||.|..         
Mouse  3575 TTTTATAPTPTPPAATTPVT------SAPALVAATAISTITVAASTTVTTPTTATTTVSTSTTKG 3633

  Fly   186 -------------------------------------HSLD-------ANSLIALYEQCRAADSY 206
                                                 ||..       ||.|:    |....||.
Mouse  3634 SKSPAKVGEGGSGIDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLL----QLSRGDSG 3694

  Fly   207 DR-----------------ICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQ 254
            .|                 :|..||.:.:.:........|.|:       .|.|  ||..|.:||
Mouse  3695 TRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQ-------CETL--SPDGLPEEQ 3750

  Fly   255 LRT--LEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEP---EEEDDDVCSSQSSDTLVDL 314
            .:|  |:|          ::..:.:.|.|....|    |:..|   .|......|..:|.|....
Mouse  3751 PQTTKLKG----------KMQSRFDMAENVVIVA----SQKRPLGGRELQLPSMSMLTSKTSTQK 3801

  Fly   315 PGLRRVQRLLFGCQIRAITEK---------------------LTSSVIQL---SDWVIYMRTDWE 355
            ..||.:|.::   |:|..|.:                     :.::|.||   :|.:|.|..:.:
Mouse  3802 FFLRVLQVII---QLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQ 3863

  Fly   356 RVIHCLVICFDLATNTNNSVV-----DMDYLDRVLPKLCQAASAM-----------------PVP 398
            |...........::|.:.:.|     .|| :|:..|......|.:                 .:|
Mouse  3864 RARRQQQAATSESSNQSETSVRREESPMD-VDQPSPSAQDTQSIVISDGTPQGEKEKEEKPPELP 3927

  Fly   399 AQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASEL 463
            ..:....:      |:|..::..|.:::       ||| .:..:::    ||:....|..|....
Mouse  3928 LLSEQLSL------DELWDMLGECLKEL-------EES-HDQHAVL----VLQPAVEAFFLVHAT 3974

  Fly   464 ERPSCRVPLEDRTEAATASGSAAVEDDLFVYN-SLLEPHMPKFAEDQFEKELQVSAIDCRKP--- 524
            ||.| :.|:.|..|    |..|.::|:....: :.|.|..|...:..|.:|.....|....|   
Mouse  3975 ERES-KPPVRDTRE----SQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDT 4034

  Fly   525 --LIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYD 587
              .:...|.:...|::.::....:|:....|                    :|....:|  |.:|
Mouse  4035 QKFLRFAETHRTVLNQILRQSTTHLADGPFA--------------------VLVDYIRV--LDFD 4077

  Fly   588 SRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQL 652
            .:.:.:.:....|           .|...:.|:.:.||||.:..|:...|.   ..:|:::|.:|
Mouse  4078 VKRKYFRQELERL-----------DEGLRKEDMAVHVRRDHVFEDSYRELH---RKSPEEMKNRL 4128

  Fly   653 VVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENG-----AQFTLI 712
            .:.|.||:|.|.||:.:|::.:|..|:|||.:.:| :....:.:.:...|..:.     :.|..:
Mouse  4129 YIVFEGEEGQDAGGLLREWYMIISREMFNPMYALF-RTSPGDRVTYTINPSSHCNPNHLSYFKFV 4192

  Fly   713 GIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQ 776
            |.|:..|:|:|..|...|....|:.::|....:.|:.......|:.|..:|:   .|:..: ::.
Mouse  4193 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE---NDVSTLGYDL 4254

  Fly   777 TFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGF-EMVTD 840
            ||.....: ||.....:|.|||.::||.:.||:.:|:|.....:...|.:|..||.:|| |::  
Mouse  4255 TFSTEVQE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEII-- 4316

  Fly   841 ESPLKL--LFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKL 903
              |.:|  :|..:|:|:|:.|....|..:|:::|.|. .|...|..||.||..:.:....|:.|.
Mouse  4317 --PKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKF 4378

  Fly   904 LEFTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLM 961
            |:|.||:::||:.|...|       :..|.|....:||||::|||||.|.||.|.|.|||...|:
Mouse  4379 LQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLL 4443

  Fly   962 KAI-NYSKGFGM 972
            .|| ..|:|||:
Mouse  4444 LAIQECSEGFGL 4455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 16/113 (14%)
HECTc 620..971 CDD:238033 111/367 (30%)
HECTc 647..970 CDD:214523 103/339 (30%)
Huwe1XP_006528996.1 DUF908 92..367 CDD:399185
DUF913 431..892 CDD:399192
UBA_HUWE1 1395..1434 CDD:270474
WWE 1695..1756 CDD:397111
fibronec_FbpA <2809..>2992 CDD:411474
DUF4414 3044..3071 CDD:405126
DUF4414 3089..3120 CDD:405126
HECTc 4101..4454 CDD:238033 111/365 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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