Protein Alignment Ube3a and HACE1

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_065822.2
• Gene: HACE1 / 57531
• HGNCID: 21033
• Length: 909
• Species: Homo sapiens
• Alignment Length: 1008
• Identity: 234/1008 - (23%)
• Similarity: 389/1008 - (38%)
• Gaps: 242/1008 - (24%)

  Fly    44 IKRYFHQLQSGCGNANC--------SNANCASSGKVAPMTPNEVAAR--------ALQLFSQDAQ 92
            :||....:.:.||:..|        :|.|...   ::..||..:|||        .|..:|.|..
Human    64 VKRSLLHIAANCGSVECLVLLLKKGANPNYQD---ISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

  Fly    93 LC-----------------EAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQS 140
            :|                 |..........|||:       ..:.|.:...:...:...||.:..
Human   126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDV-------EDAMGQTALHVACQNGHKTTVQCL 183

  Fly   141 QSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADS 205
            ..:.|    .::.|.::.:.| |..| ..|...|:..........:..|.|.:..| :.| ....
Human   184 LDSGA----DINRPNVSGATP-LYFA-CSHGQRDTAQILLLRGAKYLPDKNGVTPL-DLC-VQGG 240

  Fly   206 YDRICHAIGVVFSSVDRLGKSFIRSA--EPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDS 268
            |...|.   |:.....||.::.|:..  |....:.|:::|                 ||
Human   241 YGETCE---VLIQYHPRLFQTIIQMTQNEDLRENMLRQVL-----------------EH------ 279

  Fly   269 TQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAIT 333
               :.:||||......|     |.||....:.....|.||:....:..|.|:.|:.  |.:
Human   280 ---LSQQSESQYLKILT-----SLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRMF--CHV---- 330

  Fly   334 EKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVP 398
                                           |.:..::.::.:||.|.....|:     |.:..|
Human   331 -------------------------------FRIGPSSPSNGIDMGYNGNKTPR-----SQVFKP 359

  Fly   399 AQARLARIWAAHCSDQLHSLIAA-------CQQQITLQVLLDEESMRENESIISVTKVLKIVFYA 456
                |..:|  |..|:...|||.       ...:|| .:||.::...::.:.|...:......|.
Human   360 ----LELLW--HSLDEWLVLIATELMKNKRDSTEIT-SILLKQKGQDQDAASIPPFEPPGPGSYE 417

  Fly   457 NILASELE-RPSCRVPLEDRTEAA---------TASGSAAVEDDLFVYNSL-LEPHM--PKFAED 508
            |:.....| :|..   |..|.||:         ||:..:||....::..|. :.|.|  |:|.|.
Human   418 NLSTGTRESKPDA---LAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEF 479

  Fly   509 QFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAF 573
            ..:.:..:.....|.|.|..:.|:                                        |
Human   480 VCKHDEVLKCFVNRNPKIIFDHFH----------------------------------------F 504

  Fly   574 ILTPSTKVDALYYDSRMRMYSER----YSSLHSILNNIGQVGQEDNP---RP----DLKLTVRRD 627
            :|.....:....:..:.:.:.:|    |..|||        ||.|:.   ||    |: |.|.||
Human   505 LLECPELMSRFMHIIKAQPFKDRCEWFYEHLHS--------GQPDSDMVHRPVNENDI-LLVHRD 560

  Fly   628 QLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEE 692
            .:...:   .|:|:.:|...||:.:.|.|.||:|:.: ||.:|:|.::..||.||.:.:|.|..:
Human   561 SIFRSS---CEVVSKANCAKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSAD 621

  Fly   693 TNNMWFNATPFENGAQ---FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPA 754
            ......|:..:.|...   |...|.|:|||:.:...:.:.|....|:.::|....:.|::...|.
Human   622 GTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPE 686

  Fly   755 LYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFL 819
            ..|:|:.:||....|:.  .|.||.:. :||||.:.:..|.|.|..:||.|:||..:|.|.::..
Human   687 YAKNLQWILDNDISDLG--LELTFSVE-TDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELR 748

  Fly   820 LNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQY 884
            :...|:.|.|||.:||.|....|.:: ||...|:|:|:.|..|.|..:...:|.|..||..:...
Human   749 MTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPV 812

  Fly   885 IQDFWSIVHAMPSEDKHKLLEFTTGSARVPVG---------GLKCLRLLITRHGPDSDRLPTSHT 940
            ||.||.:|..:..|::..||:|.|||:|||.|         ||:...:....:.|  :.||||.|
Human   813 IQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTP--NLLPTSST 875

  Fly   941 CFNVLLLPEYSSREKLEERLMKAINY-SKGFGM 972
            |.|:|.||||.|:|.|::||:.|::. |.|:.|
Human   876 CINMLKLPEYPSKEILKDRLLVALHCGSYGYTM 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	15/65 (23%)
		HECTc	620..971	CDD:238033	119/363 (33%)
HACE1	NP_065822.2	N-terminal helix important for homodimerization. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367	1..21
		ANK 1. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	23..55
		ANKYR	26..249	CDD:440430	37/205 (18%)
		ANK 2. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	64..93		6/28 (21%)
		ANK repeat	66..95	CDD:293786	6/28 (21%)
		ANK repeat	97..128	CDD:293786	8/30 (27%)
		ANK 3. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	97..126		8/28 (29%)
		ANK repeat	130..161	CDD:293786	4/37 (11%)
		ANK 4. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	130..159		3/28 (11%)
		ANK repeat	163..194	CDD:293786	4/34 (12%)
		ANK 5. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	163..192		4/32 (13%)
		ANK 6. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	196..226		5/31 (16%)
		ANK repeat	196..221	CDD:293786	5/26 (19%)
		ANK 7. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	228..253		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..433		6/37 (16%)
		HECTc	554..903	CDD:238033	117/359 (33%)