Protein Alignment Ube3a and HECW2

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_006712709.1
• Gene: HECW2 / 57520
• HGNCID: 29853
• Length: 1579
• Species: Homo sapiens
• Alignment Length: 1313
• Identity: 294/1313 - (22%)
• Similarity: 466/1313 - (35%)
• Gaps: 426/1313 - (32%)

  Fly     1 MNGG-GGGEDDQHLPGV---------------SSASGSAAGAVGGRAT----------------- 32
            :||. |...||:.:||.               |:|.|:...:....:|
Human   351 VNGDLGSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSP 415

  Fly    33 PEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSGKVAPMTPNEVAARA-------------- 83
            |..::.::...:....|...|..|.|.||..:..:|.|:....|.:....|
Human   416 PRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQ 480

  Fly    84 --------------LQLFSQ-----DAQLC-------------EAFTSEANS----PQDVDMLS- 111
                          |.:||:     |..|.             ||.|.||.|    |:::..|:
Human   481 QDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAE 545

  Fly   112 ---------------PNDSSSSSSGSS-------TSTITSASTTTTTSRQSQSTPAAVVVPVSSP 154
                           |....|:..||:       ....||.:.|.|:.....|..|     ||.
Human   546 SSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRA-----VSE- 604

  Fly   155 YLTQSVPQLDIAGAEHS--SGDSEPCTPTLAPVHSL-DANSLIALYEQCRAADSYDRICH-AIGV 215
              |:|:.|    |:|.|  |.::||..|  |...|: :|::..........|||   .|: ::..
Human   605 --TESLDQ----GSEPSQVSSETEPSDP--ARTESVSEASTRPEGESDLECADS---SCNESVTT 658

  Fly   216 VFSSVDRLGKSFIRSAE----PAASSSLQE--LLANSP----------------GALNKEQLRTL 258
            ..||||....| :.||.    ||.||..:|  ..|..|                |:|...|:.:.
Human   659 QLSSVDTRCSS-LESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSG 722

  Fly   259 EGEHDKDEDSTQQVDEQSE---------SAANATATAESVESEAEPEEEDDDVC----------- 303
            |.|....|.:|  |.:|.|         |...|.|.|||...|.....|....|
Human   723 EDEGPGAESAT--VPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGAT 785

  Fly   304 -SSQSS--DTLVDLPGLRR-VQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTD------WERVI 358
             .||::  ..|..||.:|: |.|                          |.|.|      ||..|
Human   786 GGSQANGHQPLRSLPSVRQDVSR--------------------------YQRVDEALPPNWEARI 824

  Fly   359 --HCLVICFDLATNT-----------------NNSVVDMDYLDR-------------------VL 385
              |..:...|....|                 :||:..|:.|:|                   .:
Human   825 DSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAI 889

  Fly   386 PKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEE------------SMR 438
            ....:.|......|..|...| ..|.:.:  |.|....|...::.|:..|            .|.
Human   890 DGAGEEADFHQASADFRRENI-LPHSTSR--SRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMF 951

  Fly   439 ENESIIS--VTKVLK-------------IVFYANILAS-ELERP--------------------- 466
            .|.:.:.  :|||.:             :|.:.|:.|: :||.|
Human   952 TNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSR 1016

  Fly   467 -----SCRVPLEDR------------TEAATASGSAAVEDDLF-----------VYNSLLEPHMP 503
                 ..|:||:..            |...:.|.....||...           .:|::..|
Human  1017 TTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRP--- 1078

  Fly   504 KFAEDQFEKELQVSAID-----CRKPLI--PLEE-----FYNEALSENIQM-------------- 542
                 |::..:.|:..|     .|:|.|  .|:|     ..|.:|.|.||.
Human  1079 -----QYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS 1138

  Fly   543 HHDYLSYKTLAMESEIGSG-------HANYFSFMLYAFILTP---------STKVDALY---YDS 588
            ..|.:...:| .|.||.|.       |.:|......:.:.:|         :.:..|.|   :::
Human  1139 DADLVMLLSL-FEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEA 1202

  Fly   589 RMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKK-QL 652
            ::|.:   |..|.:       .|....| ..|||.:|||.|:.||   ...:...:.|||:: :|
Human  1203 KLRNF---YRKLET-------KGYGQGP-GKLKLIIRRDHLLEDA---FNQIMGYSRKDLQRNKL 1253

  Fly   653 VVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMW------FNATPFENGAQFTL 711
            .|.||||:|:|..|.|:|||.|:..|:|||.:|:|  :...|:.:      .:|....:...|..
Human  1254 YVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLF--EYSANDTYTVQISPMSAFVDNHHEWFRF 1316

  Fly   712 IGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQ 776
            .|.|:|||:.:...|...|....|:.|:......:||.......::||:.|.|   .|:.::.:.
Human  1317 SGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKD---NDIHDILDL 1378

  Fly   777 TFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDE 841
            ||.:: .:|||.:.:.||.|.|.::.|.:.||:.::.....:.:...:.||..:..:||..|.|
Human  1379 TFTVN-EEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVD- 1441

  Fly   842 SPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEF 906
            :.|..:|...|:|:::.|:.|.|..:..|:|.|.|||.:....|:.||:.|....:|.:.:||:|
Human  1442 ARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQF 1506

  Fly   907 TTGSARVPVGGLKCLRLLITRHGPDSDR------------LPTSHTCFNVLLLPEYSSREKLEER 959
            .||::.:|..|...||      |.:..|            ||.:|||||.|.||.|.|...|.|:
Human  1507 VTGTSSIPYEGFASLR------GSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEK 1565

  Fly   960 LMKAINYSKGFGM 972
            |:.|:..:..||:
Human  1566 LLTAVEETSTFGL 1578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	14/86 (16%)
		HECTc	620..971	CDD:238033	114/369 (31%)
HECW2	XP_006712709.1	HECW_N	45..162	CDD:465177
		C2_NEDL1-like	185..321	CDD:176073
		DMP1	<352..707	CDD:462128	78/372 (21%)
		PHA03169	591..>801	CDD:223003	59/229 (26%)
		WW	816..845	CDD:459800	6/28 (21%)
		HECW1_helix	922..988	CDD:465766	10/65 (15%)
		WW	994..1023	CDD:459800	1/28 (4%)
		HECTc	1223..1577	CDD:238033	114/369 (31%)