DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ube3a and SMURF1

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_065162.1 Gene:SMURF1 / 57154 HGNCID:16807 Length:757 Species:Homo sapiens


Alignment Length:658 Identity:165/658 - (25%)
Similarity:287/658 - (43%) Gaps:166/658 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 LLDEESMRENESIISVTKVLKIVFYANI-----LASELERPSCRVPLEDRTEAATASGSAAVEDD 490
            ::|...:.|||..:          |.:.     |:..:|.|:   |..|.|.||...|:.     
Human   149 VVDCRGLLENEGTV----------YEDSGPGRPLSCFMEEPA---PYTDSTGAAAGGGNC----- 195

  Fly   491 LFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLI-----------------PLEEFYNEALSE 538
                         :|.|.. .::.::.|...|.|.:                 .|.|.|.:..:.
Human   196 -------------RFVESP-SQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTV 246

  Fly   539 NIQMH--HDYLSYKTL------AMESEIGSGHANYFSFMLYAFIL-------------------- 575
            ..|::  |......|.      :....|..|.|.:    ||.|:|                    
Human   247 QGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAF----LYEFLLQGHTSEPRDLNSVNCDELGP 307

  Fly   576 ---------TPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRP------------- 618
                     |.|.::..:.:::|...:::  ..||.|:|:..|:.:...|.|             
Human   308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTD--PRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELP 370

  Fly   619 ------DL---------------------KLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEF 656
                  ||                     ::.|.|:::..::   ...:....||||||:|:|:|
Human   371 AQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEES---YRQIMKMRPKDLKKRLMVKF 432

  Fly   657 VGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWF-------NATPFENGAQFTLIGI 714
            .||:|:|.|||::|:..|:..|:.||.:|:|  |..|:|::.       :..| ::.:.|..:|.
Human   433 RGEEGLDYGGVAREWLYLLCHEMLNPYYGLF--QYSTDNIYMLQINPDSSINP-DHLSYFHFVGR 494

  Fly   715 IIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFK 779
            |:|||:::...:...|.:..|::|:|.....:||....|.|:|||..:|:   .|:..|.:.||.
Human   495 IMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILE---NDITPVLDHTFC 556

  Fly   780 ISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPL 844
            :.: :.||.::||||.|||::|.|.:.||:.:|.||.::.....||.||.|.:|||..:..:..|
Human   557 VEH-NAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLL 620

  Fly   845 KLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTG 909
            | .|..:|:|:::.|..:.|..:.:::|..:....: |..::.||..|.....|.:.:||:|.||
Human   621 K-PFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD-SNIVRWFWQAVETFDEERRARLLQFVTG 683

  Fly   910 SARVPVGGLKCLRLLITRHGP----------DSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAI 964
            |.|||:.|.|.|:......||          ::|.||.:|||||.:.:|.|.|.|||.|:|:.|:
Human   684 STRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAV 748

  Fly   965 NYSKGFGM 972
            ..:.||.:
Human   749 EETCGFAV 756

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166
HECTc 620..971 CDD:238033 121/388 (31%)
HECTc 647..970 CDD:214523 115/339 (34%)
SMURF1NP_065162.1 C2_Smurf-like 14..138 CDD:176028
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..237 6/62 (10%)
WW 236..267 CDD:197736 6/30 (20%)
WW 307..339 CDD:197736 3/33 (9%)
HECTc 399..754 CDD:238033 119/366 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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