DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and wwc3

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001103940.1	Gene:	wwc3 / 566492	ZFINID:	ZDB-GENE-070209-229	Length:	1148	Species:	Danio rerio

Alignment Length:	553	Identity:	104/553 - (18%)
Similarity:	178/553 - (32%)	Gaps:	159/553 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQS 142
            ::..:.|:|..|:.||....|.:.|.     .::.:.|.|||:.........|.......|.|:.
Zfish   124 QIKQQRLELAQQEMQLFNQLTQDDNR-----SITSSHSGSSSNAKYDPDQIKAEIACRRERLSRL 183

  Fly   143 TPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYD 207
            ......:.....|....|..|.....:.||..:.         :.||...  |::.:.|:
Zfish   184 KQELAQMRQELQYKEMGVETLQEIDRKMSSSQTN---------YKLDEAQ--AIFSELRS----- 232

  Fly   208 RICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQV 272
                                |:.|........|:|:.    :|.|..|...        ||..:|
Zfish   233 --------------------IKKAISTGEKERQDLIQ----SLAKLTLNFC--------DSINEV 265

  Fly   273 DEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLT 337
            ...:||.|::.:..:..::..:.:...:  ..||.|..|.|        |:....|.....:|::
Zfish   266 TNNAESLADSCSVQQYTDAGCQTDLMGE--FGSQESSLLAD--------RVKLSWQYEEAKKKMS 320

  Fly   338 SSVIQLS-----DWV--IYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAM 395
            |...||:     .|.  .....||:        |..|.......:.::..|.:.     |.:|..
Zfish   321 SIQHQLAQLDSESWSGRAEADRDWD--------CLQLLREKETLLQELTLLSQQ-----QHSSDT 372

  Fly   396 PVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEES---MRENESIISVT----KVLKIV 453
            .:..|....|:     .|::....:|..|....::||.|:.   ||:.|....:|    ..||.:
Zfish   373 LLQLQEEKRRL-----QDEVQRAHSAQSQGANQRILLQEKRNVLMRQLEEATRITTYLHSQLKSL 432

  Fly   454 FYANI-LASELERPSCR-----------------------VPLEDRTEAATASGSAAVEDDLFVY 494
            ..:|: ::|...|.|..                       :|..||||     ||:.|.|..|.|
Zfish   433 SASNLTVSSSSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYDRTE-----GSSDVLDPSFRY 492

  Fly   495 NSLLEPHM------PKFAED------QFEKELQVSAI----------------DCRKPLIPLEEF 531
            ...||.|.      ||.:.|      .......:|::                ||  ||..:.|.
Zfish   493 LLPLESHSSGSAYGPKRSHDTPQSLTSLSSRSSLSSLSPPSSPMDTPYHSAPQDC--PLAQMTEE 555

  Fly   532 YNEA-----LSENIQMHHDYLSYKTLAMESEIG 559
            |.|.     |:|.::.......:.||:.:.|:|
Zfish   556 YMEVASRGLLAEGLRTQSQAQQHTTLSGDGEVG 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	4/15 (27%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
wwc3	NP_001103940.1	WW	17..46	CDD:278809
		WW	64..93	CDD:278809
		C2_Kibra	677..800	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900