DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and trip12

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	1249	Identity:	259/1249 - (20%)
Similarity:	449/1249 - (35%)	Gaps:	418/1249 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PEMKRSAVRSLIKRYFHQLQSGCGNA---NCSNA------------------NCASSGKVAPMTP 76
            ||:.:..:::|....:....|..|.|   .|..|                  |.|.|..:|.|
Zfish   937 PELAKCFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLRNHAVSSHIASM-- 999

  Fly    77 NEVAARALQLFSQDAQLCEA------------FTSEANSPQ-------DVDMLSPNDSSSSSSGS 122
              ::::.|::.....|:.|.            |..|....|       :|.:.||..:.:|.:.|
Zfish  1000 --LSSQDLKIVVGSLQMAEILMQKLPDVFSVYFRREGVMHQVKNLAESEVFLTSPPKACTSGTAS 1062

  Fly   123 -STSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSV-PQLDIAGAEHSSG------------ 173
             .|:|||:|:||..    |..||     .:.||....|: ..||::.....|.
Zfish  1063 LCTTTITTATTTAA----SNVTP-----DLGSPSFQHSMDDSLDLSPQGRLSDVLKRKRLPKRGP 1118

  Fly   174 --------------DSEPCTPTLAP------VHSLDANSLIALYEQCRAADSY-DRICHAIGV-- 215
                          |::..:||...      :.||:..:...|..|..:|:|. .|.....|:
Zfish  1119 RRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGKLGTQANSANSEPSRTAGVSGLAR 1183

  Fly   216 ------VFSSVDRLGKSFIRSAEPAASSSLQ-----ELLANSPGALN-KEQLRTLEGEHDKDEDS 268
                  |.::.|:: |::|:.   .||..::     |.:..|..||| .::|.|          :
Zfish  1184 VPPKDSVSNNRDKI-KAWIKE---QASKFVERYFNSESVDGSNPALNVLQRLCT----------A 1234

  Fly   269 TQQVDEQSESAANATATAESVESEAEPEEEDDD-----------VCSSQSSDTLVDLPGLRRVQR 322
            |:|::.|.:|.........|:.||::....:..           :.|:...||:.....::|...
Zfish  1235 TEQLNLQMDSGVECLEEISSIVSESDVSSFEIQHSGLVKQLLLYLTSNSERDTISRDERIKRFLH 1299

  Fly   323 LLFGCQI-----------------RAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATN 370
            :.|||.|                 .|:..|:.:.:.|:..:.:        .:|      |..:.
Zfish  1300 VFFGCPIPGQEPPGRLDPTENGPLLALVHKMNNCLSQMEQFPV--------KVH------DFPSG 1350

  Fly   371 TNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAH---CSDQLH---------------- 416
            ..|.              .:.:.|:         :.:..|   |..|.|
Zfish  1351 NGNG--------------SRGSQAL---------KFFNTHQLKCQLQRHPDCTNVKQWKGGPVKI 1392

  Fly   417 ---SLIAACQQQITL----QVLLDEESMRENESIISVTKVL------------KIVFYAN----- 457
               :|:.|.::.:.:    ::..::|...::.|...:.:.|            ::.||..
Zfish  1393 DPLALVQAIERYLVVRGYGRIREEDEDSDDDGSDDEIDESLAAQFLNSGSVRHRLQFYIGEHLLP 1457

  Fly   458 ------------ILASELERPSC---RVPL------------------ED-------------RT 476
                        .|.:|.||.|.   ..||                  ||             |.
Zfish  1458 YNMTVYQAVRQFSLQAEEERESTDDEANPLGRAGIWTKTHTVWYKPVREDEEGCKDAVGGKRGRA 1522

  Fly   477 EAA---TASGSAAVEDDLF-------VYNSLL------EPHMPKFAEDQFEKELQVSAID----- 520
            :.|   |:..:|..:|:|:       |.|.|.      .|....|.:...|..|.:..:.
Zfish  1523 QTAPTKTSPRNAKKQDELWHEGVCPSVANPLETYLICDPPEGITFDDPSMEVILLLRVLHSISRY 1587

  Fly   521 ---------CRKPLIPLEEFYNEALS--ENIQMHHDYLSYKTLAME---SEIGSGHANYFSFMLY 571
                     | |.:||..||.|..|:  .|.|: .|.|...|..:.   :|:|.....:|.|
Zfish  1588 WFYLYDNAAC-KEIIPTGEFINSKLTAKANRQL-QDPLVIMTGNIPTWLTELGKTCPFFFPF--- 1647

  Fly   572 AFILTPSTKVDALYYDSRMRMY----SERYSSLHSILNNIGQVGQEDN------PRPD-LKLTVR 625
                           |:|..::    .:|..::..:|:...::.|.|:      ||.| .|.|:.
Zfish  1648 ---------------DTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTIN 1697

  Fly   626 RDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEE------------ 678
            ||:|:..|    |.| |.:....:..|.:::..|.|... |.::||:.|:.:|
Zfish  1698 RDELLKQA----ESV-MQDLGSSRAMLEIQYENEVGTGL-GPTQEFYALVSQELQRADLGLWRGE 1756

  Fly   679 ---IFNPAFGMFIQQEETNNMWFN----ATPFENGA----------QFTLIGIIIGLAIYNNVTL 726
               :.||..|   .||.|..|:.:    |.||....          :|..:|.::..||.:...|
Zfish  1757 EVTLSNPKVG---SQEGTKYMFSSRGLFAVPFGRTTKPAHIAKIKMKFRFLGKLMAKAIMDFRLL 1818

  Fly   727 AVNFPMVVYRKLIGYCGTFA--DLSDWSPALYKSL---------KSMLDYQGQDMEEVFEQTFK- 779
            .:...:..|:.::.:..:.:  ||.:..|.:.||:         |..::.......|..:|..:
Zfish  1819 DLPLGLPFYKWMLRHESSISSHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALES 1883

  Fly   780 -----ISYSDV--------FGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAF 831
                 .|..|:        |.::   ||...|:||.|..||.|.::.|...:.||..:.:||.:|
Zfish  1884 LNMNGCSVEDLGLDFTLPGFPNI---ELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESF 1945

  Fly   832 RKGFEMVTDESPLKLL--FRPEEIEMLVCGSR--EFDFVELENSTVYEGGYTEKSQYIQDFWSIV 892
            |:|||.|   .||..|  |.|||::.|:|||:  .:|...|......:.|||..|:.::..:.::
Zfish  1946 REGFESV---FPLHHLQYFYPEELDQLLCGSKSESWDVKTLMECCRPDHGYTHDSRAVRFLFEVL 2007

  Fly   893 HAMPSEDKHKLLEFTTGSARVPVGGLKCLR--LLITR------HGPDSDRLPTSHTCFNVLLLPE 949
            .:..:|.:...|:|.|||.|:||||.:.|.  |.|.|      ..|| |.||:..||.|.|.||:
Zfish  2008 SSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPD-DFLPSVMTCVNYLKLPD 2071

  Fly   950 YSSREKLEERLMKA 963
            |||.|.:.|:|:.|
Zfish  2072 YSSIEIMREKLLIA 2085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	13/74 (18%)
		HECTc	620..971	CDD:238033	114/410 (28%)
		HECTc	647..970	CDD:214523	105/383 (27%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915
		HECTc	1693..2094	CDD:238033	114/409 (28%)
		HECTc	1711..2090	CDD:214523	105/386 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900