Protein Alignment Ube3a and smurf2

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001107898.1
• Gene: smurf2 / 563633
• ZFINID: ZDB-GENE-030131-1830
• Length: 765
• Species: Danio rerio
• Alignment Length: 598
• Identity: 166/598 - (27%)
• Similarity: 275/598 - (45%)
• Gaps: 110/598 - (18%)

  Fly   460 ASELERP----SCRVPLEDRTEAATASGSAAV-EDDLFV------------YNSLLEPHMPKFAE 507
            |||...|    ||.|  ::.|...|.:|:|.| .||..|            |.|....|.|....
Zfish   192 ASEYSSPGRPLSCLV--DENTPIMTPNGAAGVPADDPRVQERRVRSQRHRNYMSRTHLHTPPDLP 254

  Fly   508 DQFEKEL-------------------------QVSAIDCRK--PLIPLEEFYNEALSENIQMHHD 545
            :.:|:..                         .:|.::|.:  ||.|..|..|.|......:.|:
Zfish   255 EGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNVNCEELGPLPPGWEIRNTATGRVYFVDHN 319

  Fly   546 YLSYKTLAMESEIGSGHANYFSFMLYAFILTPS-----TKVDALYYDSRMRMYSERYSSLHS--- 602
              :..|...:..:.   ||..      .:|.||     ..|:| ...||.....|:..|:.|
Zfish   320 --NRTTQFTDPRLS---ANLH------LVLNPSPNGSRAAVEA-QSSSRPGQLKEQAQSVVSPGN 372

  Fly   603 ----------------------ILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNP 645
                                  ||..  ::.|:.......::.|.|:::..::   ...|....|
Zfish   373 LPEDPECLTVPKYKRDLVQKLKILRQ--ELSQQQPQAGHCRIEVSREEIFEES---YRQVMKMRP 432

  Fly   646 KDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMF-IQQEETNNMWFN---ATPFENG 706
            |||.|:|:|:|.||:|:|.|||::|:..|:..|:.||.:|:| ..:::...:..|   |...|:.
Zfish   433 KDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHL 497

  Fly   707 AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDME 771
            :.|..:|.|:|:|:::...:...|.:..|::|:|...|..|:....|.|:.||..:||   .|:.
Zfish   498 SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILD---NDIT 559

  Fly   772 EVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFE 836
            .|.:.||.:.: :.:|:::||||.|||:.:.|.|..|:.:|.||.::.....||.||.|.:|||.
Zfish   560 GVLDHTFCVEH-NAYGEIIQHELKPNGKSIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFN 623

  Fly   837 MVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKH 901
            .|..:..|| .|..:|:|::|||..:.|..:.:::|..: ..|..|..::.||..|.:...|.:.
Zfish   624 EVIPQHLLK-AFDEKELELIVCGLGKIDINDWKSNTRLK-HCTPDSNIVKWFWRAVESYDEERRA 686

  Fly   902 KLLEFTTGSARVPVGGLKCLR-----LLITRHGPD--SDRLPTSHTCFNVLLLPEYSSREKLEER 959
            :||:|.|||:|||:.|.|.|:     .|.|.|..|  ::.||.:|||||.:.:|.|.|.:||.::
Zfish   687 RLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNNLPKAHTCFNRIDIPPYESYDKLYDK 751

  Fly   960 LMKAINYSKGFGM 972
            |:.||..:.||.:
Zfish   752 LLTAIEETCGFAV 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	120/361 (33%)
		HECTc	647..970	CDD:214523	114/333 (34%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736	1/30 (3%)
		WW	298..330	CDD:197736	8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..375		8/34 (24%)
		HECTc	410..762	CDD:238033	119/360 (33%)
		HECTc	437..762	CDD:214523	112/330 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810