DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and hectd2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_009304826.1	Gene:	hectd2 / 562999	ZFINID:	ZDB-GENE-100405-3	Length:	756	Species:	Danio rerio

Alignment Length:	463	Identity:	175/463 - (37%)
Similarity:	265/463 - (57%)	Gaps:	34/463 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 PLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDS 588
            |:||..:|||..| ::|....||.:::.        .|::|.|:|..:.|||:...|...:..||
Zfish   313 PIIPFTDFYNLTL-DHIDFMEDYHTWQV--------HGNSNRFTFCQFPFILSTVVKKAIIQRDS 368

  Fly   589 RMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLV 653
            ..:|.|   .:..::::.:.:..:.|.....|.:.|||.||::|:|..|.    ....||||:|.
Zfish   369 EQQMIS---MARQTLVDKVSRRQRVDMSLLFLNIKVRRLQLVSDSLDELS----RKRADLKKKLK 426

  Fly   654 VEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGL 718
            |.||||.|:|.||::||:|.|::.:||:..:|||...:|:...||::...:|.::|.|:|.::||
Zfish   427 VTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMFTYVKESQCYWFSSWKCDNYSEFRLVGALMGL 491

  Fly   719 AIYNNVTLAVNFPMVVYRKL-------------IGYCG-TFADLSDWSPALYKSLKSMLDYQGQD 769
            |:||::||.:.||..||:||             :|... |..||....|.|...|..:|.|:| :
Zfish   492 AVYNSITLDIRFPPCVYKKLLTPPIVPCDLDTPVGMATLTLDDLQQIMPDLAHGLGELLSYEG-N 555

  Fly   770 MEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKG 834
            :||.|..||:: :.:..|.|..:.|.|.|..:.|...|::.:|.||.|||||.:|.:||.||..|
Zfish   556 VEEDFYTTFQV-FQEELGVVKAYNLKPGGDKIPVTNLNRKEYVQLYIDFLLNKSIYRQFAAFYHG 619

  Fly   835 FEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSED 899
            |..|...:.|.|| ||||:|:|||||...|...|:....|| ||::....|:.||.:|.|.|.|.
Zfish   620 FHSVCASNALMLL-RPEEVEILVCGSPNLDMGSLQRVVQYE-GYSKTDPTIRAFWDVVLAFPLEL 682

  Fly   900 KHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAI 964
            :.|||.|||||.||||||:..|...|::....:|.||.||||||.:.||.|.|:::|.::|..||
Zfish   683 QKKLLHFTTGSDRVPVGGMADLNFKISKIDVSTDWLPVSHTCFNQICLPPYKSKKELRQKLTIAI 747

  Fly   965 NYSKGFGM 972
            :.::|||:
Zfish   748 SNAEGFGL 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	150/364 (41%)
		HECTc	647..970	CDD:214523	140/336 (42%)
hectd2	XP_009304826.1	HECTc	397..754	CDD:238033	150/364 (41%)
hectd2	XP_009304826.1	HECTc	420..753	CDD:214523	140/336 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720