DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and herc5.1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_017211386.1	Gene:	herc5.1 / 559981	ZFINID:	ZDB-GENE-090311-56	Length:	884	Species:	Danio rerio

Alignment Length:	1016	Identity:	217/1016 - (21%)
Similarity:	370/1016 - (36%)	Gaps:	248/1016 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNGGGGGEDDQHLPGVSSA-SGSAAGAVG-GRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNA 63
            ::.||.......|.||... .|::||.:| |..|.....:.|.||.::..  :...||..:  .|
Zfish    68 ISAGGNHSFVLSLSGVVFGWGGNSAGQLGLGDTTDRFVPTVVNSLKRKKI--VSISCGGEH--TA 128

  Fly    64 NCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTIT 128
            ..|..|.|........           .||......:.:.|:.|..|..:..|..:.|.:.:.::
Zfish   129 ALAKGGTVFTFGSGGF-----------GQLGHNSFKDEHHPRLVAELWGSKVSQVTCGRNHTLVS 182

  Fly   129 SASTTTTTS-------------RQSQSTPAAVVVPVSSP--YLTQSVPQLDIAGAEHS------- 171
            :||.....|             :..||.|    :||..|  |..:...|..:||..||
Zfish   183 TASPKLIYSFGCGMQGQLGNGEQVKQSVP----LPVDQPTEYNDEYTIQKLVAGENHSFALYFKE 243

  Fly   172 -SGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAA 235
             ..::.| .||.. :.:.| |.:|   |||.......:....:..||||...|..||:::.....
Zfish   244 LGNEANP-DPTRG-IMTFD-NGMI---EQCECGKDPRKAIKDLKKVFSSAASLNGSFLKTRHDGH 302

  Fly   236 SSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDD 300
            ..:.:|......| |.:..:.||...........:.:.|......|...|.|
Zfish   303 YQTSEEYCGLDFG-LVESSIATLSRNERLISTVLKVLQESLLPTLNPNPTGE------------- 353

  Fly   301 DVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICF 365
                 :|....:.||.|  :..|. ..|...:||.|.|.::.||
Zfish   354 -----ESLRLYILLPEL--ISHLK-SEQKAELTEALASKILNLS--------------------- 389

  Fly   366 DLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARI-WAAHCSDQLHSLIAACQQQITLQ 429
                                            ||..|:..| |:....|.|
Zfish   390 --------------------------------PAALRVLEIYWSKLPDDWL-------------- 408

  Fly   430 VLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVY 494
                       ::::.:.|.....|:..|:...:
Zfish   409 -----------KNLVKLFKKASAKFFGRIIVENV------------------------------- 431

  Fly   495 NSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTL------- 552
            |::.:.||.||.|                   .|:..|....|.|..:...|.....:
Zfish   432 NNVAKTHMLKFVE-------------------ILQRVYQVCCSANRNIKKRYFIIHEVNNLLDVL 477

  Fly   553 -AMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHS---ILNNIGQVGQE 613
             .|.:::.:   |:..|.|       :.::.||  :::...|.|.:..|.|   |.|...:....
Zfish   478 QTMNADVNN---NWPWFNL-------TGQIHAL--EAQRNAYEETFRKLTSFPCIFNLEAKCSYM 530

  Fly   614 DNP--RPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIV 676
            .|.  :...:|||||..|:.|.|..|......:.:|  |.|.:.|............::||..:.
Zfish   531 RNRVWKGRFELTVRRTALLEDCLCLLNPGTQQHLRD--KWLSILFTENVSKRTDVHKRDFFLNVF 593

  Fly   677 EEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGY 741
            :|:.:||..:|:..:....:||.|.......::.|.||:.|||..|:..:.:.||:.:::||:..
Zfish   594 KELCDPASQLFMYNDNETMIWFPAKLTVEKKKYFLFGILCGLAFNNSSVVNLPFPLALFKKLLNI 658

  Fly   742 CGTFADLSDWSPALYKSLKSMLDYQGQDMEE-VFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQ 805
            ..:..|..:::|...:||:.:|:|....:|| ....|...|.|::..|..:.|           |
Zfish   659 KPSLEDFIEFNPVHGRSLQYILEYSNDVLEESSLPLTIIWSGSELDLDPAEPE-----------Q 712

  Fly   806 H----NKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFV 866
            |    |:..||:.|.|.:.|.::::.|..||:|| ....|..|..:|.|||:..::.|:.|:|:.
Zfish   713 HITTSNRTKFVDEYVDHIFNQSVKEAFEEFRRGF-FRGCEKRLVEMFEPEELRGVLVGNEEYDWN 776

  Fly   867 ELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPD 931
            .|:.:|.|||.:......|..||.:...:...:|...|.|.||..|||:.|:..:::.:| |..:
Zfish   777 ILKQNTTYEGVFNADHPVIISFWEVFDDLTPNEKKSFLLFLTGFERVPILGMSAVKMRVT-HLAN 840

  Fly   932 S--DRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            |  |.||.:.||.::|.||:|..||.|..::::||::.:||
Zfish   841 STEDHLPETLTCHSLLQLPKYEKRETLRAKVIEAISHKRGF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	10/53 (19%)
		HECTc	620..971	CDD:238033	104/358 (29%)
		HECTc	647..970	CDD:214523	93/329 (28%)
herc5.1	XP_017211386.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820