DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and nedd4l

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_021324687.1	Gene:	nedd4l / 559634	ZFINID:	ZDB-GENE-051118-2	Length:	1279	Species:	Danio rerio

Alignment Length:	939	Identity:	218/939 - (23%)
Similarity:	358/939 - (38%)	Gaps:	232/939 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSV--PQLDIAGAEHS---S 172
            |.::.::.....|::...|.|...::..|....|..|..|..::::.:  .||||...:.|   .
Zfish   488 NHNNRTTQWKRPSSVDVVSETENDNQLRQINQEAHRVFRSRRHISEDLENEQLDIRDIDDSWEPI 552

  Fly   173 GDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASS 237
            .:.:|...|....|||...|.:|: ......|..|.|...:.:   :.|..|:.      |..||
Zfish   553 SEEDPTLLTDGLNHSLSGPSSLAM-PLSSTPDFSDEISLRLSL---APDTNGEI------PGPSS 607

  Fly   238 SLQELLANSPGALNKEQLRT---LEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEED 299
            ::|..|::        :||:   .:|..|:.:..|.  .:.|::......|...||....|
Zfish   608 AVQSHLSS--------RLRSSSMTDGVSDQAQPPTP--TQSSQTRRTRAQTVTGVEDTMSP---- 658

  Fly   300 DDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVIC 364
                   |:...:..|||..      |.:.|...:..|..|...:     ..|.|.|.|
Zfish   659 -------SASYALTTPGLPP------GWEERKDPKGRTYYVNHNN-----RSTTWTRPI------ 699

  Fly   365 FDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSD-QLHSLIAACQQQITL 428
              |..:|.         |.....:.....|......|......:.|.|: |:....:.....:||
Zfish   700 --LQQHTE---------DGASTSVAAVGGATAATPPASTPSTSSGHLSEPQVRRPRSLSSPTVTL 753

  Fly   429 QVLLD-----------------------------EESMRENESIISVTKVLKIV-----FYA--N 457
            ...|:                             :...:.|:|.:.....::|.     |:.  |
Zfish   754 SSPLEGANNVPIRRAVKDTFSNPQSPQPSPYSSPKTQHKANQSFLPPGWEMRIAPNGRPFFIDHN 818

  Fly   458 ILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAE--------------- 507
            ...:..|.|..:.|:..||:|:...|......:|        |..|.:.|
Zfish   819 SRTTTWEDPRLKYPVHMRTKASLDPGDLGPLPNL--------PEEPGWEERVHADGRTFYIDHNN 875

  Fly   508 --DQFE-KELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFM 569
              .|:| ..||..||  ..|.:|        .|...:..:||.. |.|...::|    .|.|...
Zfish   876 KKTQWEDPRLQSPAI--TGPAVP--------YSREFKQKYDYFR-KKLKKPADI----PNRFEMK 925

  Fly   570 LYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDAL 634
            |:                 |..::.|.|                           ||
Zfish   926 LH-----------------RNNIFEESY---------------------------RR-------- 938

  Fly   635 IGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFN 699
                ::::..|..||.:|.:||..|:|:|.|||::|:|.|:.:|:|||.:|:| :...|:|....
Zfish   939 ----IMSLKRPDSLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLF-EYSATDNYTLQ 998

  Fly   700 ATPFENG-------AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYK 757
            ..| .:|       :.|..||.:.|:|:|:...|...|....|:.::|...|..|:.......|.
Zfish   999 INP-NSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYN 1062

  Fly   758 SLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNT 822
            |||.:|:   .|..|: :..|.|. .|.||...|.:|.|:|.|::|...||:.:::|...:....
Zfish  1063 SLKWILE---NDPTEL-DLRFCID-EDNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVN 1122

  Fly   823 NIEQQFNAFRKGFEMVTDESPLKL--LFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYI 885
            .:::|.|||.:||   |:..|:.|  :|...|:|:|:||..:.|..:....|||:.||......|
Zfish  1123 RVQKQMNAFLEGF---TELIPIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVI 1184

  Fly   886 QDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPD---------SDRLPTSHTC 941
            |.||..|..|.:|.:.:||:|.||::|||:.|   ...|...:||.         .|:||.:|||
Zfish  1185 QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG---FAELYGSNGPQLFTIEQWGTPDKLPRAHTC 1246

  Fly   942 FNVLLLPEYSSREKLEERLMKAINYSKGF 970
            ||.|.||.|.:.|.|.|:|:.|:..::||
Zfish  1247 FNRLDLPMYETFEDLREKLLMAVENAQGF 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	119/369 (32%)
		HECTc	647..970	CDD:214523	114/340 (34%)
nedd4l	XP_021324687.1	C2	<374..430	CDD:326325
		WW	473..499	CDD:306827	1/10 (10%)
		WW	669..698	CDD:306827	7/39 (18%)
		WW	798..829	CDD:197736	5/30 (17%)
		WW	856..885	CDD:238122	4/28 (14%)
		HECTc	946..1275	CDD:214523	114/341 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910