DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and ube3b

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001108154.1	Gene:	ube3b / 556864	ZFINID:	ZDB-GENE-060526-231	Length:	1069	Species:	Danio rerio

Alignment Length:	704	Identity:	173/704 - (24%)
Similarity:	283/704 - (40%)	Gaps:	173/704 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 RTDWERVIHCLVIC--FDLATNTNNSV-----VDMDYLDRVLPKLCQAASAMPVPAQARLARIWA 408
            |.|...|.....||  :..|..|...:     ..:.|||.:||||                  ||
Zfish   452 RVDSAEVQKVCSICVLYQTALTTLTQIRLQILTGLTYLDELLPKL------------------WA 498

  Fly   409 AHC---------------------SDQLHS-LIAACQQQITLQVLLDEESMREN------ESIIS 445
            ..|                     |.||.: |:..|.....|..:||:..:.|.      |.:::
Zfish   499 FICELGPQGGLRLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKMEELVT 563

  Fly   446 VTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLF--VYNSLLEPHMPKFAED 508
            ::..|....|..:....||               .|.|...   |||  |:..|:.
Zfish   564 ISSFLNTFVYKMVWDGILE---------------NAKGEKL---DLFHSVHGWLMV--------- 601

  Fly   509 QFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAF 573
            .:|:       |||:...|.:.:..:.|..::           |..|.|.|...|...
Zfish   602 LYER-------DCRRRFTPEDHWLRKDLKPSL-----------LFQELEKGKKRAQLL------- 641

  Fly   574 ILTPSTKVDALYYDSRMRMYSERYSSLHSIL----NNIGQVGQEDNPRPDL-KLTVRRDQLINDA 633
                      |.|...:..:..|.....:|:    ..:|.| :..:..|.: .:|:||.:::.|
Zfish   642 ----------LQYIPHVIPHKNRVLLFRNIVTKEKETLGLV-ETSSASPHVTHITIRRSRMLED- 694

  Fly   634 LIGLEMVAMSNPKDLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEET 693
              |.:.:.......:|..:.|:||.     |.|||:.||.|||.:.|::::||||..:|......
Zfish   695 --GYDQLRRLPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFKTTSGN 757

  Fly   694 NNMWFNATP--FENGAQ-FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIG-YCGTFADLSDWSPA 754
            ..::.:.|.  .||..| |..:|.::|.|:|..:.:.|.|......:::| :..||....|..|:
Zfish   758 ERLYPSPTSSIHENHLQLFEFVGKMLGKAMYEGIVVDVPFASFFLSQVLGHHHSTFYSSIDELPS 822

  Fly   755 L----YKSLKSMLDYQGQDMEEVFEQTFKISY-SDVFGDVVQHELVPNGQDVLVGQHNKELFVNL 814
            |    ||:|.|:..|.|    :|.:....:|| .:|.|.:|.|||:|.|:.:.|...||..:::|
Zfish   823 LDSEFYKNLTSIKRYDG----DVSDLGLTLSYDEEVMGQLVCHELIPGGKTMPVTNENKISYIHL 883

  Fly   815 YSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG-SREFDFVELENSTVYEGGY 878
            .:.|.::|.|::|..||.:||..:.:...|.:...| |::.|:.| :.|.|..:|:..|||.||:
Zfish   884 MAHFRMHTQIKEQTAAFIRGFRSIINPEWLHMFSTP-EVQRLISGDNAEIDLDDLKKHTVYYGGF 947

  Fly   879 TEKSQYIQDFWSIVHA-MPSEDKHKLLEFTTGSARVPVGG---------LKC------------- 920
            ....:.|...|.|:.: ...:::...|:|.|..:|.|:.|         ::|
Zfish   948 HSSHRVILWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1012

  Fly   921 ---LRLLIT-RHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
               ||...| |......|||||.||||:|.||.||.:..|.::|..||:.:.||
Zfish  1013 GSVLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGF 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	117/394 (30%)
		HECTc	647..970	CDD:214523	110/364 (30%)
ube3b	NP_001108154.1	IQ	28..50	CDD:197470
		HECTc	683..1067	CDD:238033	117/392 (30%)
		HECTc	708..1066	CDD:214523	110/362 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900