DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ube3a and UBR5

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_056986.2 Gene:UBR5 / 51366 HGNCID:16806 Length:2799 Species:Homo sapiens


Alignment Length:1248 Identity:255/1248 - (20%)
Similarity:414/1248 - (33%) Gaps:401/1248 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 SGCGNANCSNANCASSGKVAPMTPNEVAARALQLF--SQDAQLCEAFTSEANSPQDVD------M 109
            |...::|..||:...|...|....:|..|.::..|  ..|:|..::..|:::|.|..|      |
Human  1626 SESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFM 1690

  Fly   110 L------SPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSP----YL-------- 156
            |      :.|.|.::.:..:..::..|...|...|.:.:.|::...|.:|.    |:        
Human  1691 LDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRS 1755

  Fly   157 -TQSVPQLDIAGAEHSSGDSEPCT--PTLAPVHSL------DANSLIALYEQCRAADSYDRICHA 212
             |.|......|.|..:|..|...|  .:||..:|:      |...||..|...    .|.:|..|
Human  1756 GTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHL----VYSQIPAA 1816

  Fly   213 IGVVF----------------------SSVD------RLGKSFIRSAEP---------AASSSLQ 240
            :.:.:                      |.:|      |.|.:...:.:|         :.:|:.:
Human  1817 VKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARR 1881

  Fly   241 ELLANSPGALNKEQLRTLEGEHDKDEDSTQQ--VDEQSESAANATATAESVESEAEPEEEDD--- 300
            |.:.    |..:..||||||.......|.:|  :..:.:....|.:...|     ..:|..|   
Human  1882 ERMT----AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRS-----HNDEHSDVLP 1937

  Fly   301 --DVCS----------------SQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWV 347
              ||||                :.:..|.:|.|.|.|               |.|..:::|.   
Human  1938 VLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLER---------------KRTRELLELG--- 1984

  Fly   348 IYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLP-------KLCQAASAM-------PVP 398
                .|.|...|      :...:||.|....|..|..||       ...:.:.:|       |.|
Human  1985 ----IDNEDSEH------ENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNP 2039

  Fly   399 AQARLARIWAAHCSDQLHSL-----------------------IAACQQQITLQ----------- 429
            .:..||.  |...:||.|.|                       ...|..::|:.           
Human  2040 FEVPLAE--AIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKM 2102

  Fly   430 ------------------------VLLDE-ESMRENESIISVTKVLKIVFYANILASELE----- 464
                                    ||.:| ||.:...|...:...||....|.|..:|.|     
Human  2103 SYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLT 2167

  Fly   465 --RPSC------------------------RVPLEDRTEAATASGSAAVEDDLF-VYNSLLEPHM 502
              ||.|                        ||.:||   .....||...|...| |..|.....|
Human  2168 SFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMED---VGAEPGSILTELGGFEVKESKFRREM 2229

  Fly   503 PKFAEDQFEKELQVSAIDCRKPLIPL------EEFYNEALSENIQMHHDYLSYKTLAMESEIGSG 561
            .|....| .::|.:.....|..||..      ..|.....:..:.:|...:::|.   |...|||
Human  2230 EKLRNQQ-SRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKD---EPGEGSG 2290

  Fly   562 HA-NYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPD------ 619
            .| ::::.:..||:  .:.|:..|  :.........::||...|.|.|:..:|.....:      
Human  2291 VARSFYTAIAQAFL--SNEKLPNL--ECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSG 2351

  Fly   620 LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKE------FFQLIVEE 678
            |:...|||:                .:|.::||.::....:...||..|.:      ..|.:.|.
Human  2352 LRAGSRRDR----------------DRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER 2400

  Fly   679 IF------NPAF-----GMFIQQEETNNMWFNATP------------------FENGAQ------ 708
            ::      .|||     ||.::......:...|:.                  .||||.      
Human  2401 LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLG 2465

  Fly   709 ---------------------------------------------------------------FT 710
                                                                           |.
Human  2466 LVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFR 2530

  Fly   711 LIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSM-LDYQGQDMEEVF 774
            .||.|:||.:..|....:.....|.:.|:|....:.|.:.:.|.:|:||:.: |..|..|.:.||
Human  2531 NIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVF 2595

  Fly   775 ---EQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFE 836
               :..|.|......|. .|.||:|||.::.|...|...:|..|::..:....||..:|.|||..
Human  2596 SAMDLAFAIDLCKEEGG-GQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLL 2659

  Fly   837 MVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVY---EGGYTEK-SQYIQDFWSIVHAMPS 897
            .|..::.|:.| ..|:..:||.|..|.:...|.:.|.:   .|...|| .|:.:.|||||..|..
Human  2660 DVLPKNSLEDL-TAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSM 2723

  Fly   898 EDKHKLLEFTTGSARVPVG--GLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERL 960
            .::..|:.|.|.|..:|..  |.:.:. .||...||...|||::||.:.|.:|.|||::.|:::|
Human  2724 TERQDLVYFWTSSPSLPASEEGFQPMP-SITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKL 2787

  Fly   961 MKAINYSKGFGML 973
            :.||. :|.||.:
Human  2788 LLAIK-TKNFGFV 2799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 11/42 (26%)
HECTc 620..971 CDD:238033 106/464 (23%)
HECTc 647..970 CDD:214523 102/436 (23%)
UBR5NP_056986.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..175
CUE_UBR5 184..230 CDD:270606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..352
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..648
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 999..1031
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1075
ZnF_UBR1 1177..1244 CDD:197698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1299..1318
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1515..1740 24/113 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1859..1890 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1984..2021 10/49 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2117..2142 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2323..2392 16/84 (19%)
PolyA 2389..2452 CDD:197769 8/62 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2473..2493 0/19 (0%)
HECTc 2501..2796 CDD:214523 84/298 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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