DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Wwc2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001102581.1	Gene:	Wwc2 / 498630	RGDID:	1559427	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	166/835 - (19%)
Similarity:	267/835 - (31%)	Gaps:	269/835 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SASGSAAGAVGGRATPEMKRSAVRSLIKR------YFHQLQSGCGNANCSNANCASSGKVAPM-- 74
            :|.|..:.|:..|...|.||..:...::.      |.:.......::..|.::.:|.|.:|..
  Rat   387 AARGLPSRALAERLKLEEKRKELLQKLEETTKLTTYLYSQLKSLSSSTLSMSSGSSLGSLASSRG 451

  Fly    75 --------TPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDML--------------------- 110
                    :.|.:::..|...||..|:      :.:....:|.|
  Rat   452 SLNTSSRGSLNSLSSSDLYYSSQGDQM------DTDYQYKLDFLLQEKGGYIPSGPITTIHENEV 510

  Fly   111 --SPNDSSSS-------SSGSSTSTITSA--STTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLD 164
              ||:....|       ::.|.|..:|.|  |.|:.:||.|.|:    :.|..||.:..|.
  Rat   511 VKSPSQPGQSGLCGLGVAATSHTPPLTEASKSVTSLSSRSSLSS----LSPPGSPLVLDST---- 567

  Fly   165 IAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFI- 228
            ..|:.|   |:.|        |...|:     .|.|..:..:..|......|....|..|.|..
  Rat   568 FPGSSH---DTSP--------HQFTAD-----LEDCELSRHFADIGLGENQVLLDSDSGGPSQSL 616

  Fly   229 ---RSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVD--EQSESAANATATAE- 287
               :..:......|.|..|:...:|.|.:...|.|      |.|.:|.  ...||.|..:...|
  Rat   617 LEDKDLDECTGGLLYEGSADVEKSLPKRRGLHLRG------DKTARVSAAASDESVAGDSGVYEA 675

  Fly   288 SVESEAEPEE---EDDDVC-------------SSQSSDTLVDLPGLRRV--------QRLLF--- 325
            ||:...|.|:   .::||.             .::||..:|.:..||.:        .::.|
  Rat   676 SVKQPGEIEDIPYREEDVTIVETAQVQIGLRYDTKSSSFMVIIAQLRNLHAFSIPHSSKVYFRVA 740

  Fly   326 --------GCQIRAITEKLTSSV-------IQLSDWVIYMRTDWERVIHCLVI------CFDLAT 369
                    .|..|......|.||       :.:|..|:..:|  .||..|.|.      |.   .
  Rat   741 VLPSSADVSCLFRTKVHPPTESVLYNDVFRVAISQVVLQQKT--LRVDLCSVSKRRREECL---A 800

  Fly   370 NTNNSVVDMDYLDRV-------LPKL---C--------QAASAMPVPA--QARLARIWAAHCSDQ 414
            .|..|:.|:.:.:.:       ||..   |        |..:..|.||  .|.|         |.
  Rat   801 GTQISLADLPFSNEIFMLWYNLLPSKQIPCKKKEEGGGQPGAQSPQPALDSADL---------DA 856

  Fly   415 LHSLIAACQQQITL--QVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLED--- 474
            :.:|:|....::..  |.|..||...|.|.:                     ||..|.|.||
  Rat   857 VSALLARTSAELLAVEQELAQEEEEEEEEEL---------------------RPEHRGPGEDCLT 900

  Fly   475 -------RTEAATASGSAAVEDDLFVYNSLLEPHMPK----------FAEDQFEKELQVSAIDCR 522
                   .|.||..||....|..          |.|:          .:.||..|| :....|..
  Rat   901 MLREASAETVAAKESGVHLAEGG----------HCPEDPSPCTRGPGTSRDQCRKE-KGRTEDPG 954

  Fly   523 KP------LIPLEEFYNEALSENI-----------QMHHDYLSYKTLAMESEIGSGHANYFSFML 570
            :|      |:..|...:||:..||           ..||.::....:........|..:.:...|
  Rat   955 QPATAVPTLVDKETNTDEAVDSNIAVRPKDRSSLSSQHHPFVRSSVIVRSQTFSPGERSQYICRL 1019

  Fly   571 YAFILTPSTKVDALYYDSRMRMYSERYS--SLHSILN-NIGQVGQEDNPRP------DLKLTVRR 626
            .......||......:   :|..:||.|  ...::.. .:.:..||...|.      ||:.::.|
  Rat  1020 NRSDSDSSTLAKKSLF---VRNSTERRSLRVKRAVCQPTLRRTAQECPVRTSLDLELDLQASLTR 1081

  Fly   627 DQLIND---ALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEE 678
            ...:||   ||.||:    ...::||.|      ||..:..|.:..|.||.::::
  Rat  1082 QSRLNDELQALRGLQ----QKLEELKAQ------GETDLPPGMLGDERFQKLLKQ 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	10/69 (14%)
		HECTc	620..971	CDD:238033	17/62 (27%)
		HECTc	647..970	CDD:214523	9/32 (28%)
Wwc2	NP_001102581.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792
		YlqD	351..>420	CDD:287979	7/32 (22%)
		C2_Kibra	699..822	CDD:176062	22/127 (17%)
		Phage_Nu1	<1095..>1153	CDD:294991	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900