DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and arel1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001011393.1	Gene:	arel1 / 496863	XenbaseID:	XB-GENE-5852856	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	723	Identity:	166/723 - (22%)
Similarity:	272/723 - (37%)	Gaps:	226/723 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 VPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDE-------ESMRENESIISVTKVLKIVF 454
            ||::.::    .:|.|    :|:..|.:|.||||:..:       :|:::.||.|.....|.:|.
Frog   164 VPSKTQI----VSHFS----TLVLKCGEQHTLQVVPRDQYGNHTSDSLKDLESYILTLSELGVVG 220

  Fly   455 YANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAI 519
            .|:         .|       .:.:..|||   ::.:.::.:||:...       |:..|:...:
Frog   221 VAD---------GC-------LQVSVCSGS---QNRVLLHLALLQTGC-------FQATLRFQGL 259

  Fly   520 -------------DCRKPLIP-----------LEEF-YNEALSENIQMHHDYLSYKTLAMESEIG 559
                         |..|.::.           .|.: |..:.|.||...|  .|..|...|....
Frog   260 PINNGNFQIIVLTDGEKTIVDNNVSRSGVGVFFEGYLYPPSSSPNIPGQH--RSSSTSNDEESNA 322

  Fly   560 SGHA---------NYF-----------------SFMLYAFILTPSTKVDALYYDSRMRMYSERYS 598
            .||.         .||                 .:.|:.|.:.|.||.  ||...         .
Frog   323 DGHTVDRLKKPKKVYFYITPKQLSVKEFYLRIIPWRLFTFRVCPGTKF--LYLPP---------D 376

  Fly   599 SLHSILN-------------------------------NIGQVGQE------------------D 614
            .||.:|:                               |||  |.|                  .
Frog   377 PLHGLLSLQVDDGLQPPIEISCKDRNIMAATFTRFLHLNIG--GSETFQDKVTFFQKELRQIHCK 439

  Fly   615 NPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEI 679
            ..|..:.|.|.|..|:..:|......:.|   |..|...|.|..|:.:|.||..:|:|:||.:.:
Frog   440 KTRCKVTLKVNRHSLLESSLRATRNFSAS---DWCKNFEVVFQDEEALDWGGPRREWFELICKTL 501

  Fly   680 FNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYR---KLIGY 741
            |:....:||:..::|.                     || ::.|.....|..:.:|.   :::|.
Frog   502 FDTNNQLFIRFSDSNQ---------------------GL-VHPNPCRPPNIRVKLYEFAGRVVGK 544

  Fly   742 CGTFADLSDWSPALYKS------------LKSMLDYQGQDMEEVFEQTFKISY---SDV------ 785
            |...:.|......|.::            |:....|...|..:.|:.  |:.|   :||
Frog   545 CLFESSLGGGCEQLVRARFTRSFLAQIIGLRMHYKYFETDDPDFFQT--KVQYILTNDVIDTELS 607

  Fly   786 -----FGDVVQ----HELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGF-EMVTD 840
                 :|...|    .||:|.|..:||...||..::||.::..|:..:.::.:.|.||. |:|.|
Frog   608 FAEEKYGRAGQLEKVVELIPGGSQILVTNENKVYYLNLLANHRLSNQVREEVDHFLKGLNELVPD 672

  Fly   841 ESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGG---YTEKSQYIQDFWSIVHAMPSEDKHK 902
            .  |..:|...|:|:|:||:......:.:...|..||   :.||  .:..||::|.::..|:..:
Frog   673 N--LLGIFDENELELLMCGTGHIAVQDFQAHAVVIGGSWHFREK--VMSWFWAVVSSLTQEELAR 733

  Fly   903 LLEFTTGSARVPVGGLKCLRLLITRHG-PDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINY 966
            ||:|||||:::|.||...|.......| |....|||:|||||.|.||.|.|.|::.:.|..||:.
Frog   734 LLQFTTGSSQLPPGGFAALSPSFQIIGSPTHGTLPTAHTCFNQLCLPTYDSYEEMHKMLKLAISE 798

  Fly   967 S-KGFGML 973
            . :|||||
Frog   799 GCEGFGML 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	105/389 (27%)
		HECTc	647..970	CDD:214523	98/361 (27%)
arel1	NP_001011393.1	Filamin	56..153	CDD:366210
arel1	NP_001011393.1	HECTc	447..804	CDD:238033	105/387 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910