DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and NEDD4

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens

Alignment Length:	1141	Identity:	255/1141 - (22%)
Similarity:	414/1141 - (36%)	Gaps:	326/1141 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSA- 130
            ||..:.|.:|:....      :....||...:..:.......::||::.:.:..|:|.....|.
Human   264 SSLVIFPRSPSTTRP------TSPTSLCTLLSKGSYQTSHQFIISPSEIAHNEDGTSAKGFLSTA 322

  Fly   131 ------STTTTTSRQ-------------------SQSTPAAVVVPVSSP-------YLTQ-SVPQ 162
                  |.|..|..:                   |.:||...|...||.       :.|| ....
Human   323 VNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNTPRQTVCEKSSEGYSCVSVHFTQRKAAT 387

  Fly   163 LDIAGAEHSSGDSEP----------------------CTPT-------------LAPVHS-LDAN 191
            ||   .|.::||.:|                      |.|:             |...|| ::.|
Human   388 LD---CETTNGDCKPEMSEIKLNSDSEYIKLMHRTSACLPSSQNVDCQININGELERPHSQMNKN 449

  Fly   192 --------SLIALYEQCRAADSYDRICHAIG-----VVFSS-----VDRLGKSFIRSAEPAASSS 238
                    ||...|.......|....|...|     :.|:|     ||.|.:...|......|:|
Human   450 HGILRRSISLGGAYPNISCLSSLKHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNS 514

  Fly   239 --------------LQELLANSPG-------------------------ALNKEQLRTLEGEHDK 264
                          |..|...:|.                         .|....|....|..|.
Human   515 CKTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDD 579

  Fly   265 DEDSTQQVD------EQSESAANATATAESVESEAEPE------EEDDDVCS------------- 304
            :.:..::::      :|.::|.:       ::.:.||.      ||..|:..
Human   580 NAEQAEELEPGWVVLDQPDAACH-------LQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQ 637

  Fly   305 ---SQSSDTLVDLP-GLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICF 365
               ....|.|.|.. |..::|........|.|:|: |.||.....     ..:||      :|..
Human   638 WKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEE-TESVDNRES-----SENWE------IIRE 690

  Fly   366 DLATNTNNSVV-------DMDYLDRVLPKL-----CQAASAMPVPAQARLARIWAAHCSDQLHSL 418
            |.||..:|...       ::|....:..:|     ....||:..||.       :::.|.:..||
Human   691 DEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPAS-------SSNHSSRRGSL 748

  Fly   419 IA-ACQQQITLQVLLD---------EESMRENESIISV------TKVLKIVFYANILASELERPS 467
            .| ..::|.||.|||.         ||...|......|      |...|....|.:..|:|  .|
Human   749 QAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQL--TS 811

  Fly   468 CRVPLEDRTEAATASGSAAVEDDLFVYNSLLEP-----HMPK---FAEDQFEK-------ELQVS 517
            .:.....:::|:|:.....|.....:....|..     |.|.   |..|...|       .|::.
Human   812 SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIP 876

  Fly   518 A-------IDCRKPLIPL----EE--------FYNEALSENIQMHHDYLSYKTLAMESEIGSGHA 563
            |       :|....|.||    ||        ||   ::.||:.    ..::...:|:...:|.|
Human   877 AHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFY---INHNIKR----TQWEDPRLENVAITGPA 934

  Fly   564 NYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQ 628
            ..:|                       |.|..:|......|..     |.|.|. ..::.:||..
Human   935 VPYS-----------------------RDYKRKYEFFRRKLKK-----QNDIPN-KFEMKLRRAT 970

  Fly   629 LINDA---LIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQ 690
            ::.|:   ::|::....     ||.:|.:||.||:|:|.|||::|:|.||.:|:|||.:|:| :.
Human   971 VLEDSYRRIMGVKRADF-----LKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLF-EY 1029

  Fly   691 EETNNMWFNATPFENG-------AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADL 748
            ..|:|......| .:|       :.|..||.:.|:|:|:...|...|....|:.::....|..|:
Human  1030 SATDNYTLQINP-NSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDM 1093

  Fly   749 SDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVN 813
            .......|.||:.:|:....:::..|     |...::||...||||...|.:::|...||:.::.
Human  1094 ESVDSEYYNSLRWILENDPTELDLRF-----IIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIY 1153

  Fly   814 LYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGY 878
            |...:.....|::|..||::||..:..:..:| :|...|:|:|:||..:.|..:....|.|:.||
Human  1154 LVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLMCGLGDVDVNDWREHTKYKNGY 1217

  Fly   879 TEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDS---------DR 934
            :...|.||.||..|..|.||.:.:||:|.||::|||:.|   ...|...:||.|         ::
Human  1218 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG---FAELYGSNGPQSFTVEQWGTPEK 1279

  Fly   935 LPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            ||.:|||||.|.||.|.|.|:|.::|..||..::||
Human  1280 LPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	4/26 (15%)
		HECTc	620..971	CDD:238033	117/370 (32%)
		HECTc	647..970	CDD:214523	111/338 (33%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229
		C2	<517..570	CDD:417471	4/52 (8%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		87/466 (19%)
		WW	611..643	CDD:197736	3/31 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		8/24 (33%)
		WW	769..798	CDD:395320	5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		8/39 (21%)
		WW	842..871	CDD:395320	6/28 (21%)
		WW	893..925	CDD:197736	8/38 (21%)
		HECTc	986..1315	CDD:214523	111/344 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810