DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and CG3356

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster

Alignment Length:	1021	Identity:	236/1021 - (23%)
Similarity:	386/1021 - (37%)	Gaps:	260/1021 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 MTPNEVAARAL---QLFSQDAQLCEAFTSEANSPQDVDMLS-------------PNDSSSSSSGS 122
            :.|.|||.||.   |:.|....:|..||.:..:....|.|.             |.|....|...
  Fly   235 LRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYD 299

  Fly   123 STSTITSASTTTTTSRQS-------QSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTP 180
            :..:...|.:.:|:||:|       .......:..:.|.:|..|:..||              ..
  Fly   300 ALESAGPAESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLD--------------RR 350

  Fly   181 TLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLAN 245
            .||.:|.   :.|:.:|            ...|..:..::.:|.||.:|..            ||
  Fly   351 QLATLHQ---SPLLVIY------------VRLIAEMMPNILQLPKSTLRGH------------AN 388

  Fly   246 SPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDT 310
            :|           ....|.|:||.:..||..|..|     |.:::.:.|           |:..|
  Fly   389 AP-----------HRHRDGDDDSEESEDEDEELPA-----ARTLDYDME-----------QTCRT 426

  Fly   311 LVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLV-ICFDLATNTNNS 374
            ..:| .::..:.||....|...||::...|.||...:     :...:|:.|. ||.:|.....::
  Fly   427 SGEL-SVKERECLLESIAILNETERVDFIVQQLDPHI-----ENTHLIYALCEICHNLMIYNKHA 485

  Fly   375 VVD--MDYLDRVLPKLCQAA--------------------SAMPVPAQARLAR---IWAAHCS-- 412
            |.:  :.|.....||..:|.                    |...||....:.|   :.|..|.
  Fly   486 VFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLF 550

  Fly   413 ----DQLHSLIAACQQQITLQVLLDEESMR----ENESIISVTKVLKIVFYANILASELERPSCR 469
                ..||. :...:.::.|||......:|    ....||.::|.||.:....:   ||..|..|
  Fly   551 GRLLPTLHD-VEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLV---ELAFPETR 611

  Fly   470 VPLED------RTEAATASGSAAVEDD-----------------LFVYNSL--LEPHMPKFAEDQ 509
            ..|.:      .|||          ||                 :||.|.:  .:..:....||.
  Fly   612 SNLANYRKVLGHTEA----------DDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDH 666

  Fly   510 FEKELQVSAIDCR------------------KPLIPLEEFYNEALSENIQMHHDYLSYKTLAMES 556
            :    .|:.:|..                  :|..|:.:|..|.......|....:...|:..|
  Fly   667 W----TVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILRE- 726

  Fly   557 EIGSGHANYFSFMLYAFILTPSTKV---DALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRP 618
                          ..|::..:.:|   .:|...|:||:.....:.|..               |
  Fly   727 --------------IPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQG---------------P 762

  Fly   619 DLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEE 678
            .:.:||||..|..||   .:.:...|..||:.:..::||.     |.|||.|||.:||...:::.
  Fly   763 SVLITVRRSHLYEDA---YDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKT 824

  Fly   679 IFNPAFGMFIQQEETNNMWFN---ATPFEN-GAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLI 739
            .|:|..|.|:...: |.::.|   |..||: ...:..||.|:|.:||.|  |.|..|:..: .|.
  Fly   825 AFDPNRGFFMVTTD-NKLYPNPNVADLFEDYEKHYYFIGRILGKSIYEN--LLVELPLAEF-FLT 885

  Fly   740 GYCGTFAD-----LSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQ 799
            ...|.::|     |:...|.||::|..:.||.| |:.|: ...|.::.|.: |.....||.|.||
  Fly   886 KLAGKYSDVDIHQLASLDPELYRNLLYLKDYSG-DVSEL-NLDFTVASSSL-GQTQIVELKPQGQ 947

  Fly   800 DVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLL--FRPEEIEMLVCGSR- 861
            .:.|...|:..::.|.:|:.||..|.:..||||||...|.   |::.|  |..:|:::|:.|:.
  Fly   948 SIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVL---PIEWLYMFSNKELQILISGAEI 1009

  Fly   862 EFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL--RLL 924
            ..|..:|:....|.|.::.:...|..||.::.......:.:||:|.|..:|.|:.|.|.|  ...
  Fly  1010 PIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFF 1074

  Fly   925 ITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            |...| |.:||||:.||.|:|.||.:.:.|::.|:|:.||....||
  Fly  1075 IQNTG-DMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	8/22 (36%)
		HECTc	620..971	CDD:238033	117/370 (32%)
		HECTc	647..970	CDD:214523	107/341 (31%)
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	117/368 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	107/341 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740