DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ube3a and Hectd1

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:XP_006240148.1 Gene:Hectd1 / 362736 RGDID:1561653 Length:2610 Species:Rattus norvegicus


Alignment Length:1254 Identity:260/1254 - (20%)
Similarity:445/1254 - (35%) Gaps:400/1254 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYF---HQLQSGCGNANCSNANCAS 67
            |.:.....||.|||......:|   ::|::  |:|..|..:..   ..|.|...| ..|.::..:
  Rat  1465 GPDSSVRAPGESSAISMGIVSV---SSPDV--SSVSELTNKEAASQRPLSSSASN-RLSVSSLLA 1523

  Fly    68 SGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTI--TSA 130
            :|  |||:.   :|....|.|::....|:|.....:....:..:..:.|.|||.::|:|:  ...
  Rat  1524 AG--APMSS---SASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSDNNTNTLGRNVM 1583

  Fly   131 STTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIA 195
            ||.|:....:||.| .:..|.::..:|.|...:.      ||.:....|..|:...||......:
  Rat  1584 STATSPLMGAQSFP-NLTTPGTTSTVTMSTSSVT------SSSNVATATTVLSVGQSLSNTLTTS 1641

  Fly   196 LYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEG 260
            |......:|:...      ..:|..|     |:.|..  ||:.|.||       .:.|.|...:.
  Rat  1642 LTSTSSESDTGQE------AEYSLYD-----FLDSCR--ASTLLAEL-------DDDEDLPEPDE 1686

  Fly   261 EHDKDEDSTQQVDE------------QSESAANATATAESVESE-------------AEPEEE-- 298
            |.|::||..|:..|            |..:.:.:..|..:|.|:             .|.|||  
  Rat  1687 EDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPSGAGSRPIGEQEEEEY 1751

  Fly   299 ----------DDDVCSSQSSDTLVDL----PGLRRVQR---------------LLFGCQIR---- 330
                      |||....:....||..    ||...||:               ||...:..    
  Rat  1752 ETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLEEVECTPSPR 1816

  Fly   331 -AITEKLT-----------------------SSVIQL-------SDWVIYMRTDWERVIHCLVIC 364
             |:|.|:|                       ..::||       ||   .:|..||..   ..|.
  Rat  1817 LALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSD---KLRRIWEPT---YTIM 1875

  Fly   365 F----DLATNTNNSVVDMDYLDRV--------LPKLCQAASAMPVPAQARLARIWA--------- 408
            :    |......|..:....::.|        ||| ....:.:...|.|...|.|.         
  Rat  1876 YREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPK-NDLITYLQKNADAAFLRHWKLTGTNKSIR 1939

  Fly   409 --AHCSDQLHSLIAA----CQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPS 467
              .:||    .||||    |:......:.....|..::..|:::||               |:| 
  Rat  1940 KNRNCS----QLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTK---------------EQP- 1984

  Fly   468 CRVPLEDRTEAATASGSAAVEDDL----FVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPL 528
                   :.:|........|||.|    .:|....:|: .:.:::..:::.|.:        .|.
  Rat  1985 -------QAKAGNGQNPCGVEDVLQLLRILYIVASDPY-SRISQEDGDEQPQFT--------FPP 2033

  Fly   529 EEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYA---FILTPSTKVDALYY---- 586
            :||.::.::..|....:    :.||    :.||....:...|.:   |::...|:  .||:    
  Rat  2034 DEFTSKKITTKILQQIE----EPLA----LASGALPDWCEQLTSKCPFLIPFETR--QLYFTCTA 2088

  Fly   587 ----------DSRMRMYSERYSSLHSILNN------IGQVGQEDNPRPDLKLTVRRDQLINDALI 635
                      .:|.....||..:..|:..:      :|::..|       ::.|.|    .::|:
  Rat  2089 FGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVGRLKHE-------RVKVPR----GESLM 2142

  Fly   636 GLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFI-----QQEETNN 695
            ......|....|.|..|.|||:||:|... |.:.||:.|:..|......|.::     ..:|:.:
  Rat  2143 EWAENVMQIHADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGTWLCDDNFPDDESRH 2206

  Fly   696 M------------------WFNATPFENGAQ--------FTLIGIIIGLAIYNN--VTLAVNFPM 732
            :                  .|.| ||...:.        |..:||.:...|.:|  |.|.::.|.
  Rat  2207 VDLGGGLKPPGYYVQRSCGLFTA-PFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPF 2270

  Fly   733 ---------------VVY-----RKLIGYC------------------GTFADLSDWS------- 752
                           ::|     |.|  :|                  |:|.:.|...       
  Rat  2271 FKLMCMGDIKSNMSKLIYESRGDRDL--HCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPK 2333

  Fly   753 ---PALYKSLKSMLDYQ------GQDMEEVFEQTFK----------------------------- 779
               ||.:..:.:..|::      .:.::|:.:...|                             
  Rat  2334 PKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVLKNPSG 2398

  Fly   780 ----ISYSD------------VFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQF 828
                :|..|            ::| ....:|.|:|:|.::...|.|.:|:|..||.::|.|::|.
  Rat  2399 SGPPLSIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQM 2462

  Fly   829 NAFRKGFEMVTDESPLKLL--FRPEEIEMLVCGSREFDFV--ELENSTVYEGGYTEKSQYIQDFW 889
            .|||.||..|   .|::.|  |..||::|::||::...:.  ::.|.|..:.|||..|.....|.
  Rat  2463 EAFRDGFNKV---FPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFV 2524

  Fly   890 SIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL--RLLITRHGPDSD-RLPTSHTCFNVLLLPEYS 951
            .::..|.|:::...|:||||.:.:|.|||..|  ||.:.|....:| ..|:.:||.:.|.|||||
  Rat  2525 RVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLKLPEYS 2589

  Fly   952 SREKLEERLMKAINYSKGF 970
            |.|.:.|||: |....|||
  Rat  2590 SEEIMRERLL-AATMEKGF 2607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 13/56 (23%)
HECTc 620..971 CDD:238033 115/490 (23%)
HECTc 647..970 CDD:214523 109/461 (24%)
Hectd1XP_006240148.1 Ank_2 366..457 CDD:289560
ANK repeat 366..393 CDD:293786
ANK 369..479 CDD:238125
ANK repeat 396..426 CDD:293786
ANK repeat 428..457 CDD:293786
F5_F8_type_C 1107..1240 CDD:304887
MIB_HERC2 1277..1335 CDD:284184
HECTc 2131..2608 CDD:238033 116/497 (23%)
HECTc 2155..2607 CDD:214523 108/460 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

Return to query results.
Submit another query.