Protein Alignment Ube3a and Herc3

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001102101.1
• Gene: Herc3 / 362377
• RGDID: 1307803
• Length: 1050
• Species: Rattus norvegicus
• Alignment Length: 1088
• Identity: 264/1088 - (24%)
• Similarity: 439/1088 - (40%)
• Gaps: 238/1088 - (21%)

  Fly     6 GGEDDQHLPGVSSASGSA-------------AGAVG--GRATPEMKRSAVRSLIKRYFHQ--LQS 53
            |...|||:..|:.....:             ||:.|  |..|.| ...||..||::...|  ||.
  Rat    79 GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-DSVAVPRLIQKLNQQTILQV 142

  Fly    54 GCGNANC--------------SNANCASSGKVAPMTPNEVAARALQ------------------- 85
            .|||.:|              ::......||..|...:....|:|:
  Rat   143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSL 207

  Fly    86 ---LF----SQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSS-TSTITSASTTTT------- 135
               :|    :...||..:...:..||..|.:|........|.|.. |:.:|.:....|
  Rat   208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272

  Fly   136 ----TSRQSQSTPAAVVVPVSSPYLTQ----------SVPQLDI-----AGAEHSSGDSEPCT-- 179
                .|...:..|..|:..:.|. :||          .||...:     .||:...|....|.
  Rat   273 QLGHDSVNDEVNPRRVLELMGSE-VTQIACGRQHTLALVPSSGLIYAFGCGAKGQLGTGHTCNVK 336

  Fly   180 -PTLAPVH-SLDANSLIALYEQCRAADSYDRICH-AIGVVFSSVDRLGKSFIRSAEPAASSSLQE 241
             |:....| :..:..|.|     ||    ||..: .:..:||..|   ::|:          |..
  Rat   337 CPSPVKGHWAAHSGQLSA-----RA----DRFKYRVVKQIFSGGD---QTFV----------LCS 379

  Fly   242 LLANSPGALNKEQLRTLEGEHDKD--EDSTQQVDEQSESAANATATAESVESEAEP--------- 295
            ...||..|::   .||:...|..:  .|.|..|..|..:..|...|...|......
  Rat   380 TYENSSPAVD---FRTVNQAHYTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFL 441

  Fly   296 EEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSS-----VIQLSDW---VIYMRT 352
            |::.|:...:......:||...|.:...|...|...|.|::.:|     :.|||..   |..||
  Rat   442 EKKIDEHFKTSPKIPGIDLNSTRVLFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMR- 505

  Fly   353 DWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHS 417
                 |:.::..|.|..::..      |:...:| |..|...:.......|...|:..|......
  Rat   506 -----IYLILPEFPLLQDSKY------YITLTIP-LAMAILRLETNPSKVLDNWWSQACPKYFMK 558

  Fly   418 LIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATAS 482
            |:...:..: |.:|...::.            |..|.:.|.:.:.|
  Rat   559 LVTLYKSAV-LYLLRGRKTF------------LIPVLFNNYMTATL------------------- 591

  Fly   483 GSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYL 547
                                 |..|..::..|:|..::       .::||...:|..:.:..|||
  Rat   592 ---------------------KLLEKLYKVNLKVKHVE-------YDKFYIPEISSLVDIQEDYL 628

  Fly   548 SY---------KTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMY----SERYSS 599
            .:         :...|:..:        :...|.||.....|...|..|:.::|.    .....:
  Rat   629 MWFLHQSGMKARPSIMQDAV--------TLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQN 685

  Fly   600 LHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDE 664
            :..:|.....:.:.    |.|.|.|||:.|:.||   |..:::.:..||||.|.|.|.||:|:|.
  Rat   686 VFMLLTLEPLLARS----PFLVLHVRRNHLVGDA---LRELSIHSDIDLKKPLKVIFDGEEGVDA 743

  Fly   665 GGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVN 729
            |||:||||.|:::|:.||.:|||...:::|.:||:.|.|.....|.||||..||||||:..:.::
  Rat   744 GGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLH 808

  Fly   730 FPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHEL 794
            ||:.:|:||:....:..||.:.||...:||:.:|||.|:|:||.|...|.:. .:.:|.:.|.:|
  Rat   809 FPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLNFTVC-RESYGVIEQKKL 872

  Fly   795 VPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG 859
            :|.|..|.|.:.|::.||:.|.:::...::.:.:.||..||..|.....|: ||:|.|:..::.|
  Rat   873 IPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLE-LFQPAELRAMMVG 936

  Fly   860 SREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLL 924
            :..:::.|||.:.||:|.|:.....::.||...|..|.|.|.:.|.|.|||.|:|:.|:..|:::
  Rat   937 NSNYNWEELEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRFLLFLTGSDRIPIYGMASLQIV 1001

  Fly   925 ITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            |.......|.||.:|||:|:|.||:|||:|.::.||.:|::..:||.:
  Rat  1002 IQSTATGEDYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSL 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	17/95 (18%)
		HECTc	620..971	CDD:238033	133/350 (38%)
Herc3	NP_001102101.1	ATS1	3..341	CDD:444065	52/263 (20%)
		RCC1	313..377	CDD:395335	16/85 (19%)
		HECTc	702..1048	CDD:238033	133/350 (38%)