DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Herc6

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_008761185.1	Gene:	Herc6 / 362376	RGDID:	1561739	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	231/993 - (23%)
Similarity:	400/993 - (40%)	Gaps:	196/993 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QLQSGCGNANCSNANCASSGKVAPMTPNEVAARALQLF-------------SQDAQLCEAFTS-- 99
            |.|.|.||..||.|:......:..:...:|||.....|             ::..||..:..|
  Rat   155 QGQLGLGNNLCSQASPQKVKSLEGIPLAQVAAGGTHSFALSLMGTSFGWGNNRSGQLALSGNSAK 219

  Fly   100 -EANSPQDVDMLSPNDSSSSSSG-SSTSTITSASTTTT----TSRQSQSTPAAVVVPVSSPYLTQ 158
             :...|..:..|...:....|.| ..||.:|......|    :|.|.|.:|.:   ....|.|.:
  Rat   220 EQIYKPHSIGALKTLNVVYISCGYEHTSVLTEDGQVFTFGGSSSEQLQHSPRS---GRGGPQLIE 281

  Fly   159 S----VPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRA-ADSYDRICHAIGVVFS 218
            .    |.|:: .|:.|          |:|.|::......:.....|.: |...:..|..:..:.|
  Rat   282 GIGGHVSQIE-CGSYH----------TIAYVYTTGQVVSLGRGPSCTSNATHQEAACSDVTCLLS 335

  Fly   219 SVDRLG-----------KSFIRSAEPAASSS-----LQELLANSPGALNKEQLRTLEGEHDKDED 267
            :.|.:.           .:|:.:.....|:|     |.|::..:...:.|.:.......|   ||
  Rat   336 AKDLVDIEVKDIFAGAHANFVTTCRHTRSTSVSMKILPEIIRITQPLVKKWRAAKKGKVH---ED 397

  Fly   268 STQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAI 332
            :.:::.....|.|..||:........|            ::...|||...|.|.::|       .
  Rat   398 AKREISLIFSSPACLTASFLKKRDAGE------------NNFINVDLKLARDVFKML-------T 443

  Fly   333 TEKLTSSVIQ--LSDWVI----YMRTDWERVIHCLVI--CFDLATNTNNSVVDMDYLDRVLPKLC 389
            .||..||:|.  |.:.::    |.....|.::..|::  |..:....|...:..::        .
  Rat   444 AEKWISSLITTCLEETLLRGLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEF--------A 500

  Fly   390 QAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVF 454
            .|...|...:...|...||:.....|:||:...::.|..|:..:...|::..::
  Rat   501 SAIHKMRSKSLTFLRNWWASLEVSSLNSLVQMLKKTIVSQLHNEVPMMKDTSNL----------- 554

  Fly   455 YANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKEL----- 514
                          :|.||...|         |:..|...||.|...:||..:....|.|
  Rat   555 --------------KVSLEMMKE---------VQKILEKTNSHLHNEVPKMEDTSNLKVLLEVMK 596

  Fly   515 QVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKT----LAMESEIGSGHANYFSFML--YAF 573
            :|...:|:.|             ||..:.:|..::.|    :|.:...   ...|:|.:.  :.|
  Rat   597 EVHEANCQLP-------------ENAFIMNDIFNFNTEEGIMAKQQMF---FIKYYSMVFNDFPF 645

  Fly   574 ILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPR----PDLKLTVRRDQLINDAL 634
            ||...:|:..:.:||.:::..|              |....:|.    |...|.|||..|:.|.
  Rat   646 ILDLPSKIILMKHDSSVKLSDE--------------VKVAASPEKMGCPFFILKVRRSHLVEDT- 695

  Fly   635 IGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFN 699
              |..:..:...||:|.|.|.|:.|...:.||||.|||..|.||:.:|.:.||:..|..:||||.
  Rat   696 --LRQLRQAEDFDLRKTLSVGFINEIRPEGGGVSSEFFHCIFEEMTDPKYEMFMYPENGSNMWFP 758

  Fly   700 ATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLD 764
            ..|....:::.|.||:.||::.|...:.::||:.:|:||:....:..||.|.|..|.::|:.:|:
  Rat   759 VNPKFEKSRYFLFGILCGLSLNNLNVINLSFPLALYKKLLEQKPSLEDLKDLSLLLGRNLQEVLN 823

  Fly   765 YQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFN 829
            .:...:||:.      .|..::.|....:|:|:|..|.|.:.||..:|:...|::.|.:|:..::
  Rat   824 CEAGVIEELH------MYFSIYWDQRDVDLIPDGISVPVNETNKRDYVSKCVDYIFNISIKTIYD 882

  Fly   830 AFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHA 894
            .|.:||..|.:...:: .|:|||:...:.|:...|:.:.||::.||.||::....|..||...|.
  Rat   883 EFHRGFYKVCNRDSIR-HFQPEELMAAIIGNPTCDWKQFENNSKYENGYSKSHPTILLFWKAFHE 946

  Fly   895 MPSEDKHKLLEFTTGSARVPVGGL-------KCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSS 952
            :..::|.|.|.|.||..|:.|.||       :|..:...|..      |.|.||.::|.||:||:
  Rat   947 LTLDEKKKFLLFLTGCDRLHVKGLQNEGIRFRCPEVFSERDN------PRSLTCHSILDLPKYST 1005

  Fly   953 REKLEERLMKAINYSKGF 970
            ..:::|.|..|||.:|||
  Rat  1006 MRRMKEALQVAINNNKGF 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	13/56 (23%)
		HECTc	620..971	CDD:238033	115/358 (32%)
		HECTc	647..970	CDD:214523	106/329 (32%)
Herc6	XP_008761185.1	RCC1	39..88	CDD:278826
		RCC1	92..141	CDD:278826
		RCC1	144..194	CDD:278826	12/38 (32%)
		RCC1_2	182..210	CDD:290274	4/27 (15%)
		RCC1_2	236..265	CDD:290274	7/28 (25%)
		RCC1	252..299	CDD:278826	12/60 (20%)
		HECTc	682..1023	CDD:238033	113/356 (32%)
		HECTc	706..1023	CDD:214523	106/329 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820