Protein Alignment Ube3a and Herc6

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001012492.1
• Gene: Herc6 / 362376
• RGDID: 1561739
• Length: 1027
• Species: Rattus norvegicus
• Alignment Length: 993
• Identity: 231/993 - (23%)
• Similarity: 400/993 - (40%)
• Gaps: 196/993 - (19%)

  Fly    50 QLQSGCGNANCSNANCASSGKVAPMTPNEVAARALQLF-------------SQDAQLCEAFTS-- 99
            |.|.|.||..||.|:......:..:...:|||.....|             ::..||..:..|
  Rat   155 QGQLGLGNNLCSQASPQKVKSLEGIPLAQVAAGGTHSFALSLMGTSFGWGNNRSGQLALSGNSAK 219

  Fly   100 -EANSPQDVDMLSPNDSSSSSSG-SSTSTITSASTTTT----TSRQSQSTPAAVVVPVSSPYLTQ 158
             :...|..:..|...:....|.| ..||.:|......|    :|.|.|.:|.:   ....|.|.:
  Rat   220 EQIYKPHSIGALKTLNVVYISCGYEHTSVLTEDGQVFTFGGSSSEQLQHSPRS---GRGGPQLIE 281

  Fly   159 S----VPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRA-ADSYDRICHAIGVVFS 218
            .    |.|:: .|:.|          |:|.|::......:.....|.: |...:..|..:..:.|
  Rat   282 GIGGHVSQIE-CGSYH----------TIAYVYTTGQVVSLGRGPSCTSNATHQEAACSDVTCLLS 335

  Fly   219 SVDRLG-----------KSFIRSAEPAASSS-----LQELLANSPGALNKEQLRTLEGEHDKDED 267
            :.|.:.           .:|:.:.....|:|     |.|::..:...:.|.:.......|   ||
  Rat   336 AKDLVDIEVKDIFAGAHANFVTTCRHTRSTSVSMKILPEIIRITQPLVKKWRAAKKGKVH---ED 397

  Fly   268 STQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAI 332
            :.:::.....|.|..||:........|            ::...|||...|.|.::|       .
  Rat   398 AKREISLIFSSPACLTASFLKKRDAGE------------NNFINVDLKLARDVFKML-------T 443

  Fly   333 TEKLTSSVIQ--LSDWVI----YMRTDWERVIHCLVI--CFDLATNTNNSVVDMDYLDRVLPKLC 389
            .||..||:|.  |.:.::    |.....|.::..|::  |..:....|...:..::        .
  Rat   444 AEKWISSLITTCLEETLLRGLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEF--------A 500

  Fly   390 QAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVF 454
            .|...|...:...|...||:.....|:||:...::.|..|:..:...|::..::
  Rat   501 SAIHKMRSKSLTFLRNWWASLEVSSLNSLVQMLKKTIVSQLHNEVPMMKDTSNL----------- 554

  Fly   455 YANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKEL----- 514
                          :|.||...|         |:..|...||.|...:||..:....|.|
  Rat   555 --------------KVSLEMMKE---------VQKILEKTNSHLHNEVPKMEDTSNLKVLLEVMK 596

  Fly   515 QVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKT----LAMESEIGSGHANYFSFML--YAF 573
            :|...:|:.|             ||..:.:|..::.|    :|.:...   ...|:|.:.  :.|
  Rat   597 EVHEANCQLP-------------ENAFIMNDIFNFNTEEGIMAKQQMF---FIKYYSMVFNDFPF 645

  Fly   574 ILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPR----PDLKLTVRRDQLINDAL 634
            ||...:|:..:.:||.:::..|              |....:|.    |...|.|||..|:.|.
  Rat   646 ILDLPSKIILMKHDSSVKLSDE--------------VKVAASPEKMGCPFFILKVRRSHLVEDT- 695

  Fly   635 IGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFN 699
              |..:..:...||:|.|.|.|:.|...:.||||.|||..|.||:.:|.:.||:..|..:||||.
  Rat   696 --LRQLRQAEDFDLRKTLSVGFINEIRPEGGGVSSEFFHCIFEEMTDPKYEMFMYPENGSNMWFP 758

  Fly   700 ATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLD 764
            ..|....:::.|.||:.||::.|...:.::||:.:|:||:....:..||.|.|..|.::|:.:|:
  Rat   759 VNPKFEKSRYFLFGILCGLSLNNLNVINLSFPLALYKKLLEQKPSLEDLKDLSLLLGRNLQEVLN 823

  Fly   765 YQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFN 829
            .:...:||:.      .|..::.|....:|:|:|..|.|.:.||..:|:...|::.|.:|:..::
  Rat   824 CEAGVIEELH------MYFSIYWDQRDVDLIPDGISVPVNETNKRDYVSKCVDYIFNISIKTIYD 882

  Fly   830 AFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHA 894
            .|.:||..|.:...:: .|:|||:...:.|:...|:.:.||::.||.||::....|..||...|.
  Rat   883 EFHRGFYKVCNRDSIR-HFQPEELMAAIIGNPTCDWKQFENNSKYENGYSKSHPTILLFWKAFHE 946

  Fly   895 MPSEDKHKLLEFTTGSARVPVGGL-------KCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSS 952
            :..::|.|.|.|.||..|:.|.||       :|..:...|..      |.|.||.::|.||:||:
  Rat   947 LTLDEKKKFLLFLTGCDRLHVKGLQNEGIRFRCPEVFSERDN------PRSLTCHSILDLPKYST 1005

  Fly   953 REKLEERLMKAINYSKGF 970
            ..:::|.|..|||.:|||
  Rat  1006 MRRMKEALQVAINNNKGF 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	13/56 (23%)
		HECTc	620..971	CDD:238033	115/358 (32%)
Herc6	NP_001012492.1	ATS1	27..313	CDD:444065	36/171 (21%)
		HECTc	682..1023	CDD:238033	113/356 (32%)