DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Hace1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_006256657.1	Gene:	Hace1 / 361866	RGDID:	1306114	Length:	916	Species:	Rattus norvegicus

Alignment Length:	1026	Identity:	233/1026 - (22%)
Similarity:	388/1026 - (37%)	Gaps:	271/1026 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IKRYFHQLQSGCGNANC--------SNANCASSGKVAPMTPNEVAAR--------ALQLFSQDAQ 92
            :||....:.:.||:..|        :|.|...   ::..||..:|||        .|..:|.|..
  Rat    64 VKRSLLHIAANCGSVECLVLLLKKGANPNYQD---ISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

  Fly    93 LC-----------------EAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQS 140
            :|                 |..........|||:       ..:.|.:...:...:...||.:..
  Rat   126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDV-------EDAMGQTALHVACQNGHKTTVQCL 183

  Fly   141 QSTPAAVVVPVSSPYLTQSVPQLDIAGA-------EHSSGDSEPCTPTLAPVHSLDANSLIALYE 198
            ..:.|.:..|             ::|||       .|...|:..........:..|.|.:..| :
  Rat   184 LDSGADINRP-------------NVAGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPL-D 234

  Fly   199 QCRAADSYDRICHAIGVVFSSVDRLGKSFIRSA--EPAASSSLQELLANSPGALNKEQLRTLEGE 261
            .| ....|.:.|.   |:.....||.::.::..  |....:.|:::|
  Rat   235 LC-VQGGYGQTCE---VLIQYHPRLFQTIVQMTQNEDLRENMLRQVL------------------ 277

  Fly   262 HDKDEDSTQQVDEQSES---------AANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGL 317
                    |.:.:||||         |..||.....:.|...       :.||.||.....:..|
  Rat   278 --------QHLSQQSESQYLKILTGLAEVATTNGHKLLSVFR-------LVSSLSSSYEAQMKSL 327

  Fly   318 RRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLD 382
            .|:.|:.  |.:                                   |.:..::.::.:||.|..
  Rat   328 LRIVRIF--CHV-----------------------------------FRIGPSSPSNGMDMGYNG 355

  Fly   383 RVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAA-------CQQQITLQVLLDEESMREN 440
            ...|:     |.:..|    |..:|  |..|:...|||.       ....|| .:||.::...:.
  Rat   356 NKTPR-----SQVFKP----LELLW--HSLDEWLVLIATELMKNKEDSADIT-SILLKQKGQDQE 408

  Fly   441 ESIISVTKVLKIVFY-----------ANILASELERPS-CRVPLEDRTEAATASGSAAVEDDLFV 493
            .|.||..:......|           .::||.:.|..: |:..:     :.||:..:||....::
  Rat   409 ASCISAFEPPGPGSYERLSTGPGESKPDVLAGKQEASADCQDVI-----SVTANRLSAVIQAFYM 468

  Fly   494 YNSL-LEPHM--PKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAME 555
            ..|. :.|.|  |:|.|...:.:..:.....|.|.|..:.|:
  Rat   469 CCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFH----------------------- 510

  Fly   556 SEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSER----YSSLHSILNNIGQVGQEDNP 616
                             |:|.....:....:..:.:.:.:|    |..|||        ||.|:.
  Rat   511 -----------------FLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHS--------GQPDSD 550

  Fly   617 ---RP----DLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQL 674
               ||    |: |.|.||.:...:   .|:|:.:|...||:.:.|.|.||:|:.: ||.:|:|.:
  Rat   551 MVHRPVSENDI-LLVHRDSIFRSS---CEIVSKANCAKLKQGIAVRFHGEEGMGQ-GVVREWFDI 610

  Fly   675 IVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQ---FTLIGIIIGLAIYNNVTLAVNFPMVVYR 736
            :..||.||.:.:|.|..:......|:..:.|...   |...|.|:|||:.:...:.:.|....|:
  Rat   611 LSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK 675

  Fly   737 KLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDV 801
            .::|....:.|::...|...|:|:.:||....|:.  .|.||.:. :||||.:.:..|.|.|..:
  Rat   676 HILGIPVNYQDVASIDPEYAKNLQWILDNDISDLG--LELTFSVE-TDVFGAMEEVPLKPGGGSI 737

  Fly   802 LVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFV 866
            ||.|:||..:|.|.::..:...|:.|.|||.:||.|....|.:: ||...|:|:|:.|..|.|..
  Rat   738 LVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLSGMPEIDVN 801

  Fly   867 ELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVG---------GLKCLR 922
            :...:|.|..||..:...||.||.:|..|..|::..||:|.|||:|||.|         ||:...
  Rat   802 DWIKNTEYTSGYEREDPVIQWFWEVVEDMTQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFT 866

  Fly   923 LLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINY-SKGFGM 972
            :....:.|  :.||||.||.|:|.||||.|:|.|::||:.|::. |.|:.|
  Rat   867 IAAVPYTP--NLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTM 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	15/65 (23%)
		HECTc	620..971	CDD:238033	120/363 (33%)
		HECTc	647..970	CDD:214523	112/335 (33%)
Hace1	XP_006256657.1	ANK repeat	66..95	CDD:293786	6/28 (21%)
		ANK	66..93	CDD:197603	5/26 (19%)
		Ank_2	69..194	CDD:289560	23/147 (16%)
		ANK	92..217	CDD:238125	24/147 (16%)
		ANK repeat	97..128	CDD:293786	8/30 (27%)
		ANK repeat	130..161	CDD:293786	4/37 (11%)
		Ank_2	135..222	CDD:289560	14/106 (13%)
		ANK repeat	163..194	CDD:293786	5/43 (12%)
		ANK repeat	196..221	CDD:293786	5/24 (21%)
		Ank_4	199..249	CDD:290365	9/54 (17%)
		HECTc	561..910	CDD:238033	118/359 (33%)
		HECTc	586..909	CDD:214523	110/329 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810