Protein Alignment Ube3a and Ufd4

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 244/1173 - (20%)
• Similarity: 410/1173 - (34%)
• Gaps: 402/1173 - (34%)

  Fly    33 PEMKRSAVRSL--IKRYFHQLQSGCGNANCS----------NANCASSGKVAPMTPNEVAARA-- 83
            |..:.:||.|:  ||      :....|.|.|          |....|:.:| |.| :|||...
  Fly  1719 PAQQPNAVLSIVDIK------EQPISNENVSVPSQMSISVPNLTTTSASEV-PST-SEVATHTGL 1775

  Fly    84 LQLFS-------------QDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTT 135
            |:.|:             ||.|:..|   |||..:..|    .::|.|..|.|.:::...:.::.
  Fly  1776 LETFAAIARRRTSQGTNIQDNQIMNA---EANVNEHGD----QNASGSFLGHSVTSLVKLALSSN 1833

  Fly   136 TSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQC 200
            ......||             .||.|.|       ||.:||    .:||.:..:.::
  Fly  1834 FHSGLLST-------------AQSYPSL-------SSNNSE----NIAPSNPSNTSA-------- 1866

  Fly   201 RAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELL--ANSPGALNKEQLRTLEGEHD 263
             ...|...|.|.:.:..:|          ::..:...||::.|  ..:|..|.     .|:.|.|
  Fly  1867 -GQQSASTINHTLTMSLTS----------TSSDSEQVSLEDFLESCRAPALLG-----DLDDEDD 1915

  Fly   264 KDEDSTQQVDE-QSESAANATATA------------ESVESE----AEPEEEDDDVC-------- 303
            .|||:.::.:| :.|...|.....            |::|:.    .:.:..||:..
  Fly  1916 MDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSAL 1980

  Fly   304 ------------SSQSSDTLV-----DLP------GLRRVQRLLFGCQIR-----AITEKLTSSV 340
                        .:|:||..:     :||      |...:::.|.|.::|     .|.|    ..
  Fly  1981 IPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPE----VE 2041

  Fly   341 IQLS--DWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARL 403
            |.||  ||.|:      |.:..|:.|..|           :.||                   :.
  Fly  2042 IDLSNTDWTIF------RAVQELLQCSQL-----------NKLD-------------------KF 2070

  Fly   404 ARIWAAHCSDQLHSLIAACQQQITLQVLLDEE-------SMRENESIISVTKVLKIVFYANILAS 461
            .:||....:.....:....|:...|:   .||       |.:...|.:|....:.|.|  |:..:
  Fly  2071 RKIWEPTYTIVYREVSPEAQESTCLE---SEEFPQTPDVSSKSGASTLSPNSPMHIGF--NVADN 2130

  Fly   462 ELERPSCRVPLEDRTEAAT---------------ASGSAAVEDDLFVYNSLLEPHMPKFAEDQFE 511
            .|    |.|  :|..|..|               ..|.:.:.:|||:         .|...::.:
  Fly  2131 NL----CSV--DDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFI---------SKKITNKLQ 2180

  Fly   512 KELQVSAIDCRKPLIPLEEFYNEAL---SENIQMHHDYL-SYKTLAMESEIGSGHANYFSFMLYA 572
            :::|       .||:    ..:.||   .||:.....:| .::|..:       :.|..||....
  Fly  2181 QQIQ-------DPLV----LASNALPNWCENLNQSCPFLFPFETRQL-------YFNCTSFGASR 2227

  Fly   573 FILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGL 637
            .|:...::.|......|:.:.|.|... |..  .||::..|       ::.|.|    |:.|:..
  Fly  2228 SIVCLQSQRDVTVERQRIPIMSPRRDD-HEF--RIGRLKHE-------RVKVPR----NEDLLMW 2278

  Fly   638 EMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATP 702
            .|..|....:.|..|.|||:.|:|... |.:.||:.|:..||......|::..::......|:|.
  Fly  2279 AMQVMKTHCNRKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQ 2342

  Fly   703 FENG--------------------------------AQFTLIGIIIGLAIYN----NVTLAVNF- 730
            ...|                                ..|...|:.:...:.:    ::.|:.:|
  Fly  2343 SAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFL 2407

  Fly   731 PMVVYRKLI-------------------------------------------GYCGTFADLSDWS 752
            .::.:.|::                                           |...:..:|.:..
  Fly  2408 QLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEID 2472

  Fly   753 PALYKSLKSM---------------------------LDYQGQDMEEVFEQTFKISY-----SDV 785
            |..|:.|:.|                           |..|.|:..||..:...:::     |.:
  Fly  2473 PTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSI 2537

  Fly   786 FGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLL--F 848
            :| ..|.||:|||..|.|...|.|.:..|..:|:|...|.||..||..||..|   .|||.|  |
  Fly  2538 YG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEV---FPLKKLAAF 2598

  Fly   849 RPEEIEMLVCG------SREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFT 907
            .|.|..|::||      |||    ::.:.|..:.||.:.|...|.|.:::.:|..:::...|:||
  Fly  2599 TPSEARMMICGEQFPHWSRE----DIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFT 2659

  Fly   908 TGSARVPVGGLKCL--RLLITRH---GPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYS 967
            ||.:.:|.|||..|  ||.:.|.   |..|  .|:.:||.:.|.||:|.:.|.::|||:.|.. .
  Fly  2660 TGCSSLPPGGLANLHPRLTVVRKVDAGVGS--YPSVNTCVHYLKLPDYPTEEIMKERLLTATK-E 2721

  Fly   968 KGF 970
            |||
  Fly  2722 KGF 2724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	20/80 (25%)
		HECTc	620..971	CDD:238033	112/476 (24%)
		HECTc	647..970	CDD:214523	104/447 (23%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	1/5 (20%)
		HECTc	2265..2725	CDD:238033	113/483 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830