Protein Alignment Ube3a and CG4238

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Alignment Length: 1112
• Identity: 223/1112 - (20%)
• Similarity: 388/1112 - (34%)
• Gaps: 337/1112 - (30%)

  Fly    18 SASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQ-----SGCGNANCSNANCASSGKVAPMTPN 77
            :..|....|.||:..|.:|       :|..|.:..     |.||:..       ...::.|:...
  Fly    47 NVGGVMHAATGGKTFPTLK-------VKLCFGESMGISSLSSCGDPE-------RLPELPPLDEQ 97

  Fly    78 EVAARALQL--------FSQDAQLCEAF----TSEANSPQDVDMLSPNDSSSSS---------SG 121
            .:...||.|        :.:|.:|...:    ..|..|.:||..|  .||.:|.         ||
  Fly    98 RLQRAALHLQQKLILREWLKDHRLQHHYQRLLAVEVASLEDVYWL--EDSRASKILGKDWQLWSG 160

  Fly   122 SSTSTITS--------ASTTTTTSRQSQSTPA-----AVVVPVSSPYLTQSVPQLDIAGAEHSSG 173
            :..:..||        |...:|..:.||...|     .:||.||            :||....:.
  Fly   161 ARQNLPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLVVSVS------------VAGLVTLAA 213

  Fly   174 DSEPCTPTLAPV--HS----------LDANSLIAL-------------------------YEQCR 201
            .::   |:|||.  ||          |.||..:..                         |..|.
  Fly   214 MTQ---PSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPICD 275

  Fly   202 AADSYDRICHAIGVVFSSVDRLGKS-------------------------FIRSAEPAASSSLQE 241
            ....:..:......|. ::..||.|                         .|.::..|.|..|:.
  Fly   276 TDHFFVEVTEGTRKVV-TISELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLRS 339

  Fly   242 LLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVC--- 303
            .|   |||::..:.|.:                :..|.....|.|.:: ...||.:|..:.|
  Fly   340 FL---PGAIDARRSRFI----------------RPASTVICCAGAPTL-MHIEPRDEFGNSCLFD 384

  Fly   304 SSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLA 368
            .:||.:.|.             |.|:         ::..|....:      |::.|.:|..:| .
  Fly   385 QNQSDEALQ-------------GYQV---------AIYDLHGVPV------EKLQHAIVFAYD-K 420

  Fly   369 TNTNNSVVDM-----------DYLDRVLPK----LCQAASAMPVPAQARLARIWAAHCSDQLHSL 418
            .|:..||..:           .|.|:.||.    :...:|:........:|        .:.|::
  Fly   421 VNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIA--------SRKHNI 477

  Fly   419 IAACQQQITLQV----------LLDEESMRENESIISVT-KVLKIVFYANILASELERPSCRVPL 472
               |.:...|.:          :|.....::|..|..|| |.:.:.|....:|:....||.:..
  Fly   478 ---CYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFH- 538

  Fly   473 EDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALS 537
                               |:...:.:.|.|.|..|           |..:|.|
  Fly   539 -------------------FLPQLVSQLHGPVFIID-----------DGAQPKI----------- 562

  Fly   538 ENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFIL-------TPSTKVDALYYDSRMRMYSE 595
                               |:.|...|..:.....|:|       |...|.|..|::.| :.::.
  Fly   563 -------------------ELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVR-KFHAS 607

  Fly   596 RYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQ 660
            .|                   ...:.|.|:|::::..::..::..::|   |......|.|.|||
  Fly   608 YY-------------------HEKMALKVQREKILESSMKAVKGFSVS---DWCGNFEVTFQGEQ 650

  Fly   661 GIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENG----AQFTLIGIIIGLAIY 721
            |||.||:.:|:|:|:...:|:...|:|....:.:....:..|....    ..|...|.::|..::
  Fly   651 GIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLF 715

  Fly   722 NNV-------TLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKS-LKSML--DYQGQDMEEVF-- 774
            .:.       .:...|......:|||....:.......|.||.| :|.:|  |....|..|::
  Fly   716 ESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFV 780

  Fly   775 EQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVT 839
            |:.:..|...:...:   ||:|||....|....|..:::..:...|..|::.:.::|.||...:.
  Fly   781 EEMYDSSSGQLSKTI---ELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSII 842

  Fly   840 DESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLL 904
            .::.|. :|...|:|:|:||:.|:...:.:...:..|...|..:.:..||:.|......:..:||
  Fly   843 PDNLLS-IFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLL 906

  Fly   905 EFTTGSARVPVGGLKCL--RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINY- 966
            :||||.:::|.||.:.|  :..||. .|....|||:|||||.|.||:|.|.|:.|:.|:.||:.
  Fly   907 QFTTGCSQLPPGGFQELNPQFQITA-APTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEG 970

  Fly   967 SKGFGML 973
            |:||||:
  Fly   971 SEGFGMV 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	10/66 (15%)
		HECTc	620..971	CDD:238033	98/369 (27%)
		HECTc	647..970	CDD:214523	93/341 (27%)
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	11/98 (11%)
		Filamin	238..336	CDD:279024	11/98 (11%)
		HECTc	615..975	CDD:238033	98/367 (27%)
		HECTc	642..974	CDD:214523	92/336 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740