Protein Alignment Ube3a and Trip12

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_038939619.1
• Gene: Trip12 / 316575
• RGDID: 1306607
• Length: 2074
• Species: Rattus norvegicus
• Alignment Length: 1277
• Identity: 260/1277 - (20%)
• Similarity: 428/1277 - (33%)
• Gaps: 430/1277 - (33%)

  Fly    15 GVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNA---NCSNA------------- 63
            |.|......|.|...:..||:.:|.:::|....:....|..|.|   .|..|
  Rat   889 GYSDLKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELL 953

  Fly    64 -----NCASSGKVAPMTPNE---VAARALQL---------------FSQDAQLCEA-FTSEANSP 104
                 |.|.|..:|.|..::   :...|||:               |.::..:.:. ..:|:.|.
  Rat   954 KDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESL 1018

  Fly   105 QDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAE 169
                :.||..:.::.|||..|| |.||:.|.|:..:.|      ..:.||.|            :
  Rat  1019 ----LTSPPKACTNGSGSLGST-TPASSGTATAATNAS------ADLGSPSL------------Q 1060

  Fly   170 HSSGDS---------------------EPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAI 213
            ||..||                     .|..|..:|....|
  Rat  1061 HSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDD------------------------ 1101

  Fly   214 GVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGAL-------NKEQLRT-----LEGEHDKDE 266
                 .||...||...:..| .||.|..|...:.|.|       |.|..||     |.....||.
  Rat  1102 -----KVDNQAKSPTTTQSP-KSSFLASLNPKTWGRLSAQSNSNNIEPARTAGVSGLARAASKDT 1160

  Fly   267 DSTQQ------VDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLF 325
            .|..:      :.||:........::|:::...                     |.|..:|||..
  Rat  1161 ISNNREKIKGWIKEQAHKFVERYFSSENMDGSN---------------------PALNVLQRLCA 1204

  Fly   326 G-------------C--QIRAITEK--LTSSVIQLSDWV----IYMRTDWE--------RVIHCL 361
            .             |  :||:|..:  ::|..||.|.:|    :|:.:..|        |:...|
  Rat  1205 ATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFL 1269

  Fly   362 VICFD----------------------LATNTNNSVVDMDYLD---RVLPKLCQAASAMPVPAQA 401
            .:.|.                      |....||.:..|:...   ...|....:..:..:...:
  Rat  1270 HVFFSSPLPGEEPVGRVEPVGHAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGSGGSFSLNRGS 1334

  Fly   402 RLARIWAAH---CSDQLH-------------------SLIAACQQQIT----------------- 427
            :..:.:..|   |..|.|                   :|:.|.::.:.
  Rat  1335 QALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGIFRYGRVREDDEDS 1399

  Fly   428 --------------------------LQVLLDEESMRENESIISVTKVLKI-------------- 452
                                      ||..:.|..:..|.::....:...:
  Rat  1400 DDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSVQAEDERESTDDESN 1464

  Fly   453 -------------VFYANILASELERPSCRVPLEDRTEAA---TASGSAAVEDDLF-------VY 494
                         ::|..:...|.....|......|.:.|   |:..:|...|:|:       |.
  Rat  1465 PLGRAGIWTKTHTIWYKPVREDEESSKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVA 1529

  Fly   495 NSL---LEPHMPK---FAEDQFEKELQVSAID--------------CRKPLIPLEEFYNEALS-- 537
            |.|   |.|..|:   |.:...:..|.:..:.              | |.:||..||.|..|:
  Rat  1530 NPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMC-KEIIPTSEFINSKLTAK 1593

  Fly   538 ENIQMHHDYLSYKTLAME---SEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMY----SE 595
            .|.|: .|.|...|..:.   :|:|.....:|.|                  |:|..::    .:
  Rat  1594 ANRQL-QDPLVIMTGNIPTWLTELGKTCPFFFPF------------------DTRQMLFYVTAFD 1639

  Fly   596 RYSSLHSILNNIGQVGQEDN------PRPD-LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLV 653
            |..::..:|:...::.|.|:      ||.| .|.||.|::|:..|    |.| |.:....:..|.
  Rat  1640 RDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQA----ESV-MQDLGSSRAMLE 1699

  Fly   654 VEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEET---------------NNMWFNATPF 703
            :::..|.|... |.:.||:.|:.:|:.....|::..:|.|               |.....|.||
  Rat  1700 IQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPF 1763

  Fly   704 ENGA----------QFTLIGIIIGLAI--YNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALY 756
            ...|          :|..:|.::..||  :..|.|.:..|...:........|..||.|..|.:.
  Rat  1764 GRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVA 1828

  Fly   757 KSLKSMLDY--QGQDMEEVFEQT-----FKISYSDVFGDVVQH-------------ELVPNGQDV 801
            :|:..:.|.  |.:.:|:...||     :.:....:.|..|:.             ||...|:|:
  Rat  1829 RSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDI 1893

  Fly   802 LVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSR--EFD 864
            .|..||.|.::.|...:.||..:.:||::||.|||.|...|.|: .|.|||::.|:|||:  .:|
  Rat  1894 PVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLSHLQ-YFYPEELDQLLCGSKADTWD 1957

  Fly   865 FVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLR--LLITR 927
            ...|......:.|||..|:.::..:.|:.:..:|.:...|:|.|||.|:||||.:.|.  |.|.|
  Rat  1958 AKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVR 2022

  Fly   928 ------HGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKA 963
                  ..|| |.||:..||.|.|.||:|||.|.:.::|:.|
  Rat  2023 KTFESTENPD-DFLPSVMTCVNYLKLPDYSSIEIMRDKLLIA 2063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	15/92 (16%)
		HECTc	620..971	CDD:238033	113/401 (28%)
		HECTc	647..970	CDD:214523	104/374 (28%)
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396
		WWE	814..876	CDD:397111
		HECTc	1672..2072	CDD:238033	113/400 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900