Protein Alignment Ube3a and Hectd2

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_038936565.1
• Gene: Hectd2 / 309514
• RGDID: 1305536
• Length: 813
• Species: Rattus norvegicus
• Alignment Length: 817
• Identity: 243/817 - (29%)
• Similarity: 375/817 - (45%)
• Gaps: 165/817 - (20%)

  Fly   247 PGALNKEQLRTLEGE-HDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDT 310
            ||:    ...|.||: ...|..|..|:...|...::.|...|:.|              ::||.|
  Rat    70 PGS----SATTGEGKARGLDRGSKGQISTFSSFVSSVTQKKEAAE--------------NRSSPT 116

  Fly   311 LVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWV--------------------------IY 349
            .:.||.:|.|:.|...|  ..:.:|...|:..||..|                          ..
  Rat   117 HLALPNIRNVRDLPPIC--LDVRQKQRMSMDSLSSEVKVPPLPEPILPSQPKTVKDFEEDLEKAE 179

  Fly   350 MRTDWERVIHCLVICFDLATNTN-----------NSVVDMDYLDRVLPKLCQAASAMPVPAQA-- 401
            ...:|:.|....:..||..|..|           |::.|......::..:..|....|...|.
  Rat   180 ATGNWKTVHAFYITAFDSFTELNAAFKKDATASFNTIEDSGINANLVNAVFDALLNTPQDIQKSV 244

  Fly   402 ------RLARIW-AAHCSDQLHS---LIAACQQQITLQVLLDEESMRENESIIS----------- 445
                  .|.:.| .....|.|.:   |:...|..||...::....:|:..:::.
  Rat   245 LKGIINSLLQEWKGPRTKDDLRAYFILLQNPQFNITSTYVIYAHLLRQIATLVEADHHFLVHWLK 309

  Fly   446 ----------VTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAA-VEDDLFVYNSLLE 499
                      |.::|:.|......|...|.|    ||   |:......||| |...|...|:|:.
  Rat   310 KLSQKKFKQLVERLLQFVSLRLFPAKPEEFP----PL---TKCTWWIPSAAKVLALLNTANNLVH 367

  Fly   500 PHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHAN 564
            |                       ||:|..:|||..| ::|.:..:|.::::      .|:.|:.
  Rat   368 P-----------------------PLVPYTDFYNSTL-DHIDLMEEYHTWQS------FGNSHSR 402

  Fly   565 YFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPD-----LKLTV 624
             |||..|.|:::.:.|...:..||..:|.|....||      :.:|.:..  |||     |.:.|
  Rat   403 -FSFCQYPFVISITAKKIIIQRDSEQQMISIARQSL------VDKVSRRQ--RPDMNMLFLNMKV 458

  Fly   625 RRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQ 689
            ||..|::|:|..|    .....||||:|.|.||||.|:|.||::||:|.|::.:||:|.:|||..
  Rat   459 RRTHLVSDSLDEL----TRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTY 519

  Fly   690 QEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKL-------------IGY 741
            .::::..||::...:|.::|.|:||::|||:||::||.:.||...|:||             :|.
  Rat   520 HKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGI 584

  Fly   742 CG-TFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQ 805
            |. |..||....|.|...||.:|.|:| ::||.|..||:: :.:.||.:..:.|.|.|..:.|..
  Rat   585 CSVTIDDLCQIMPELAHGLKELLSYEG-NVEEDFYSTFQV-FQEEFGVIKSYNLKPGGDKIPVTN 647

  Fly   806 HNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELEN 870
            .|:..:|.||:|||||.:|.:||.||..||..|...:.|.|| ||||:|:|||||.|.|...|:.
  Rat   648 QNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASNALMLL-RPEEVEILVCGSPELDMHALQR 711

  Fly   871 STVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRL 935
            ||.|: ||.:....|:.||.:|...|.|.:.|||.|||||.||||||:..|...|:::...::.|
  Rat   712 STQYD-GYAKTDLTIRYFWDVVLGFPLELQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNWL 775

  Fly   936 PTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            |.:|||||.|.||.|.|::.|:::|:..|:.|:|||:
  Rat   776 PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173
		HECTc	620..971	CDD:238033	151/364 (41%)
Hectd2	XP_038936565.1	HECTc	454..811	CDD:238033	151/364 (41%)