DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Wwc1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	64/307 - (20%)
Similarity:	112/307 - (36%)	Gaps:	77/307 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LQSGCGNANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDS 115
            |:..|.:|..|:.:.|....|       ..|...:|.:.:|...::..|||.....|.:....|.
  Rat   614 LKVACVSAAVSDESVAGDSGV-------YEASMQRLGTSEAAAFDSDESEAVGVTQVQIALKYDE 671

  Fly   116 SSSSSG------SSTSTI-----------------TSASTTTTTSRQSQSTPAAVV-----VPVS 152
            .|....      |:.|.:                 :.:||....:|...|..:.|.     |.:|
  Rat   672 KSKQFAILVIQLSNLSALLLQQDQKVNIRVAILPCSESSTCLFRTRPLDSADSLVFNEAFWVSMS 736

  Fly   153 SPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVF 217
            .|.|.|...::|:...:.|  .:|.|.          ..:.|:|.|.||:.:...|..:.:.  :
  Rat   737 YPALHQKTLRVDVCTTDRS--HTEECL----------GGAQISLAEVCRSGERSTRWYNLLS--Y 787

  Fly   218 SSVDRLGKSFIRSAEPAAS------SSLQELLANSPGALNKEQ-----LRTLEGEHDKDEDSTQQ 271
            ..:.:.|    |..:||.:      .::..||..:...|.|.|     .:||||....:|::::.
  Rat   788 KYLKKQG----REPQPAEAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASEN 848

  Fly   272 VDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLR 318
                       .|.||  |.|.|.||.::||.:.:.|....:.|.|:
  Rat   849 -----------EAVAE--EEEREEEEGEEDVFAEKVSPEAEECPALK 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	9/42 (21%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
Wwc1	XP_002727807.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846
		C2_Kibra	661..784	CDD:176062	25/134 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900