DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Arel1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001100214.1	Gene:	Arel1 / 299197	RGDID:	1307597	Length:	823	Species:	Rattus norvegicus

Alignment Length:	702	Identity:	161/702 - (22%)
Similarity:	288/702 - (41%)	Gaps:	163/702 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 MPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEE---------SMRENESI-ISVTKV 449
            |.||::.::    ..|.|    :|:..|.|..|||::..:|         |:||..:. :|:.::
  Rat   162 MVVPSKTKI----VCHFS----TLVLTCGQPHTLQIVPRDEYDNPTNNSMSLREEHNYSLSIHEL 218

  Fly   450 -------LKIVFYANILASELERPSC----RVPLEDR---------------------------- 475
                   .::.|..::.::   |.:|    |:.|..|
  Rat   219 GPQEEENSEVSFEKSVTSN---RQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSENE 280

  Fly   476 ---TEAATASGSAAVEDDLFVYN----SLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYN 533
               .|...::...::..:.::||    |....|:|         .:.:|:.. |:|...|||...
  Rat   281 KNIVERNVSTSGVSIYFEAYLYNANSYSSAPWHLP---------PMHMSSSQ-RRPSTALEEEEE 335

  Fly   534 EALSENIQMH-----------HDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYD 587
            ::.||   .|           :.|:|.|..:::    ..:.....:.||.|.:.|.||...|..|
  Rat   336 DSPSE---CHTPEKVKKPKKVYCYVSPKQFSVK----EFYLKIIPWRLYTFRVCPGTKFSYLGPD 393

  Fly   588 SRMRMYS----------------ER----YSSLHSILNNIG--------------QVGQEDNPRP 618
            ...::.:                ||    .:.:.|:..|||              ::.|....||
  Rat   394 PVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRP 458

  Fly   619 DLKLT--VRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFN 681
            ..|:|  |.|..|:..:|......::|   |..|...|.|..|:.:|.||..:|:|:||.:.:|:
  Rat   459 HSKVTLKVSRHALLESSLKATRNFSIS---DWSKNFEVVFQDEEALDWGGPRREWFELICKALFD 520

  Fly   682 PAFGMFIQQEETNNMWFNATPFENG----AQFTLIGIIIGLAIYNN-------VTLAVNFPMVVY 735
            ....:|.:..:.|....:..|....    ..:...|.::|..:|.:       ..:...|.....
  Rat   521 TTSQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFL 585

  Fly   736 RKLIGYCGTFADLSDWSPALYKS-LKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQ 799
            .::||....:.......|..||| :..:|:....:||.||.:. |.:.|.....:|  ||:..|.
  Rat   586 AQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEE-KYNKSGQLDKIV--ELMTGGA 647

  Fly   800 DVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFD 864
            ...|...||..::||.:.:.|.:.::::...|.||...:..|: |..:|...|:|:|:||:.:..
  Rat   648 QTPVTNANKTFYLNLLAQYRLASQVKEEVEHFLKGLNELVPEN-LLAIFDENELELLMCGTGDIS 711

  Fly   865 FVELENSTVYEGG---YTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL----R 922
            ..:.:...|..||   :.||  .::.||::|.::..|:..:||:|||||:::|.||...|    :
  Rat   712 VSDFKAHAVVVGGSWHFREK--VMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQ 774

  Fly   923 LLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYS-KGFGML 973
            ::.   .|....|||:|||||.|.||.|.|.|::...|..||:.. :|||||
  Rat   775 IIA---APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	100/372 (27%)
		HECTc	647..970	CDD:214523	92/342 (27%)
Arel1	NP_001100214.1	Filamin	56..154	CDD:395505
Arel1	NP_001100214.1	HECTc	486..820	CDD:214523	92/342 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900