DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Bag3

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	412	Identity:	74/412 - (17%)
Similarity:	123/412 - (29%)	Gaps:	151/412 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRS--LIKRY-------------------FHQ 50
            |.:....|..|..|.|::.|    :.|...||::.|  |.:.|                   |||
Mouse   173 GPERSQSPAASDCSSSSSSA----SLPSSGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQ 233

  Fly    51 LQSGCGNANCSNANCASSGKVAPMTP-------NEVAARALQLFSQDAQLCEAFTSEANSP---- 104
            .|        .....|..|:..|..|       ::...|.|:..|.........:|...||
Mouse   234 AQ--------KTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRAASPFRSPVRGASSREGSPARSG 290

  Fly   105 ------------------------QDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQ------ 139
                                    :...:..|.:...|..|.:...:..........|:
Mouse   291 TPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGPAGPDLPPGHIPIQVIRREADSKP 355

  Fly   140 -SQSTP----------AAVVVPVSSPYLTQSV---PQLDIAG---AEHSSGDSEPCTP-----TL 182
             ||.:|          ::..:|..||....|.   |..::|.   |..|...:||..|     ..
Mouse   356 VSQKSPPPAEKVEVKVSSAPIPCPSPSPAPSAVPSPPKNVAAEQKAAPSPAPAEPAAPKSGEAET 420

  Fly   183 APVHS--LDANSLIALYEQC-RAADSYDRICHAIG------------------VVFSSVDRLGKS 226
            .|.|.  |...:::...:.. :|.||::      |                  :...|||..|::
Mouse   421 PPKHPGVLKVEAILEKVQGLEQAVDSFE------GKKTDKKYLMIEEYLTKELLALDSVDPEGRA 479

  Fly   227 FIRSAEPAASSSLQELL-------ANSPGALNKEQLR--TLEGEH-----------DKDEDSTQQ 271
            .:|.|.......:|.:|       .:.||.:...:|:  .||.|.           |||:...:.
Mouse   480 DVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEAEQPLQEIMGAVVADKDKKGPEN 544

  Fly   272 VDEQSESAANATATAESVESEA 293
            .|.|:||        :.:|::|
Mouse   545 KDPQTES--------QQLEAKA 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	14/81 (17%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		WW	23..55	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		34/205 (17%)
		BAG	426..503	CDD:214591	13/82 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577		9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900