Protein Alignment Ube3a and Wwp1

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_006237992.1
• Gene: Wwp1 / 297930
• RGDID: 1311734
• Length: 968
• Species: Rattus norvegicus
• Alignment Length: 987
• Identity: 232/987 - (23%)
• Similarity: 368/987 - (37%)
• Gaps: 268/987 - (27%)

  Fly    20 SGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCAS--SGKVAPMTPNEVAAR 82
            :|.|....|...|....|.||...|....|...|....::|    |:.  :|:..|.:|.:||.|
  Rat   213 NGDAVHENGDPLTRTTPRLAVEGTIGIDNHVSTSTVVPSSC----CSHIVNGENTPSSPPQVATR 273

  Fly    83 ALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAV 147
                 .|:....:..|||..|          |:.:..|.|..:..|||..|:..|..|.||....
  Rat   274 -----PQNTPAPKPLTSEPTS----------DTVNGESSSVLADSTSAMGTSLPSEDSTSTSNCT 323

  Fly   148 VVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHA 212
            ...|..|.: |..|    |.:|||.     |.|:.:.....:|.|||......|....:|::...
  Rat   324 STTVQEPPV-QEPP----ASSEHSE-----CIPSASAEVGPEARSLIDPDSDSRNNSGFDKVRQP 378

  Fly   213 IGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSE 277
            .|.|               ||....|         |..|.|.|.:...:.......|..||..:.
  Rat   379 EGCV---------------EPLRPQS---------GNTNTESLPSGWEQRKDPHGRTYYVDHNTR 419

  Fly   278 SAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQ 342
                 |.|.|                               |.|.|..|
  Rat   420 -----TTTWE-------------------------------RPQPLPPG---------------- 432

  Fly   343 LSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIW 407
                       |||.:           :....|..:|:..|.      .....|.....|....|
  Rat   433 -----------WERRV-----------DDRGRVYYVDHNTRT------TTWQRPTMESVRNFEQW 469

  Fly   408 AAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVP- 471
                ..|.:.|..|.||              .|:         :.::.|::||:|.: |...:|
  Rat   470 ----QSQRNQLQGAMQQ--------------FNQ---------RYLYSASMLAAEND-PYGPLPP 506

  Fly   472 -LEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEA 535
             .|.|.::.         |.::..|     |..|  ..|:|        |.|...:|.|    |.
  Rat   507 GWEKRVDST---------DRVYFVN-----HNTK--TTQWE--------DPRTQGLPNE----EP 543

  Fly   536 LSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSL 600
            |.|..::.:.....:              ||              ||   :::|...:.:..:..
  Rat   544 LPEGWEIRYTREGVR--------------YF--------------VD---HNTRTTTFKDPRNGK 577

  Fly   601 HSILNNIGQVGQE---------------DNPRPD-LKLTVRRDQLINDALIGLEMVAMSNPKDLK 649
            .|:.....|:..|               .|..|. :|:.|.|..|..|:   .:.:....|.||:
  Rat   578 SSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDS---FQQIMALKPYDLR 639

  Fly   650 KQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF-----ENGAQF 709
            ::|.|.|.||:|:|.||:::|:|.|:..|:.||.:.:| :....||......|.     ::.:.|
  Rat   640 RRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF-EYAGKNNYCLQINPASTINPDHLSYF 703

  Fly   710 TLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV- 773
            ..||..|.:|:::...:...|.:..|::::....|..||.......|.||..:.|   .::||.
  Rat   704 CFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRD---NNIEECG 765

  Fly   774 FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMV 838
            .|..|.:. .::.|.|..|:|...|.::||.:.||:.::.|.:::..:..:::|..||..||..|
  Rat   766 LEMYFSVD-MEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 829

  Fly   839 TDESPLKLL--FRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKH 901
            .   ||:.|  |..:|:|:::||.:|.|..:.:.:|||. .||..|:.|..||..|....:|.:.
  Rat   830 V---PLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVRM 890

  Fly   902 KLLEFTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEER 959
            :||:|.||:.|:|:||...|       :..|.:.|.|: .||.||||||.|.||.|.|.|:|:|:
  Rat   891 RLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEK 954

  Fly   960 LMKAINYSKGFG 971
            |:.||..::|||
  Rat   955 LLFAIEETEGFG 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	13/55 (24%)
		HECTc	620..971	CDD:238033	115/365 (32%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988
		DUF5585	<196..>431	CDD:465521	68/306 (22%)
		WW	397..426	CDD:459800	7/64 (11%)
		HUL4	<427..968	CDD:227354	166/684 (24%)