DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Bag3

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001011936.1	Gene:	Bag3 / 293524	RGDID:	1307794	Length:	574	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	84/441 - (19%)
Similarity:	129/441 - (29%)	Gaps:	188/441 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRS--LIKRY-------------------FHQ 50
            |.:....|..|..|.|::.|    :.|...||::.|  |.:.|                   |||
  Rat   170 GPERSQSPAASDCSSSSSSA----SLPSSGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQ 230

  Fly    51 LQSGCGNANCSNANCASSGKVAPMTP-------NEVAARALQLFSQDAQLCEAFTSEANSPQDVD 108
            .|        .....|..|:..|..|       ::...|.|:.           ||...||  |.
  Rat   231 AQ--------KTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRA-----------TSPFRSP--VR 274

  Fly   109 MLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQST---PAAVVVPVSSPYLTQSVPQLDIAGAEH 170
            ..|..:.|.:.||:.....:.....|...|....|   |..|..|.:.|   :|.|.|  ||.:.
  Rat   275 GASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKP---ESKPGL--AGPDL 334

  Fly   171 SSG-----------DSEP---------------------------------------------CT 179
            ..|           ||:|                                             ..
  Rat   335 PPGHIPIQVIRREADSKPVSQKPPPPAEKVEVKVSSAPIPCPSPGPAPSAVPSSPKNVAAEPKAA 399

  Fly   180 PTLAPVHSLDANS--------------LIALYEQC----RAADSYDRICHAIG------------ 214
            |:.||..:....|              :.|:.|:.    :|.|:::      |
  Rat   400 PSPAPAEAASLKSGDAEAPHKHPGVLKVEAILEKVQGLEQAVDNFE------GKKTDKKYLMIEE 458

  Fly   215 ------VVFSSVDRLGKSFIRSAEPAASSSLQELL-------ANSPGALNKEQLR--TLEGEH-- 262
                  :...|||..|::.:|.|.......:|.:|       .:.||.:...:|:  .||.|.
  Rat   459 YLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEPEQPL 523

  Fly   263 ---------DKDEDSTQQVDEQSES------AA---NATATAESVESEAEP 295
                     |||:...:..|.|:||      ||   |.::||:|..:...|
  Rat   524 QEIMGAVAADKDKKGPENEDPQTESQQLEAKAATPPNPSSTADSAGNPVAP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	13/81 (16%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
Bag3	NP_001011936.1	WW	23..55	CDD:197736
Bag3	NP_001011936.1	BAG	423..500	CDD:214591	13/82 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900