DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Wwp2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001099654.1	Gene:	Wwp2 / 291999	RGDID:	1310091	Length:	870	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	120/368 - (32%)
Similarity:	199/368 - (54%)	Gaps:	30/368 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAF 684
            :|::|.|..|..|:   .:.:....|.||:::|.:...||:|:|.||:::|:|.|:..|:.||.:
  Rat   515 VKISVSRQTLFEDS---FQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 576

  Fly   685 GMFIQQEETNNMWFNATPF-----ENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGT 744
            .:| :....||......|.     ::...|..||..|.:|:|:...:...|.:..|::::....|
  Rat   577 CLF-EYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPT 640

  Fly   745 FADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKE 809
            ..||....|..|.|:   :..:..:::|...:.|.|...::.|.|..|||...|:::.|.:.|||
  Rat   641 LRDLESIDPEFYNSI---IWIKENNLDECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKE 702

  Fly   810 LFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLL--FRPEEIEMLVCGSREFDFVELENST 872
            .::.|.:|:.....:|:|..||..||..|   :||:.|  |..:|:|:::||.:|.|..:.:.:.
  Rat   703 EYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEWLRYFDEKELELMLCGMQEIDMSDWQKNA 764

  Fly   873 VYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDS---DR 934
            :|. .||:.|:.||.||.:|..|.:|.:.:||:|.||:.|:||||   ...||..:||..   ||
  Rat   765 IYR-HYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGG---FAELIGSNGPQKFCIDR 825

  Fly   935 ------LPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFG 971
                  ||.||||||.|.||.|.|.|:|:|:|:.||..::|||
  Rat   826 VGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFG 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	118/366 (32%)
		HECTc	647..970	CDD:214523	111/338 (33%)
Wwp2	NP_001099654.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		WW	302..331	CDD:278809
		WW	332..361	CDD:278809
		WW	407..435	CDD:278809
		WW	447..477	CDD:238122
		HECTc	516..868	CDD:238033	118/365 (32%)
		HECTc	539..867	CDD:214523	111/338 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810