DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Nedd4l

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	1025	Identity:	224/1025 - (21%)
Similarity:	366/1025 - (35%)	Gaps:	359/1025 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GGGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSG 69
            ||||..:....:|.....|..:: ..|.|....|.|                            .
  Rat   531 GGGEGPEPWETISEEVNMAGDSL-SLALPPPPASPV----------------------------S 566

  Fly    70 KVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTT 134
            :.:|...:|..:|.||:           |.::|..|...::....|         |.:.|.|.|.
  Rat   567 RTSPQELSEELSRRLQI-----------TPDSNGEQFSALIQREPS---------SRLRSCSVTD 611

  Fly   135 TTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQ 199
            |.:.|      |.:.|.|:|  |:......:.|.|.|       ||::|.||:  ...|.:.:|:
  Rat   612 TVAEQ------AHLPPPSTP--TRRARSSTVTGGEES-------TPSVAYVHT--TPGLPSGWEE 659

  Fly   200 CRAADSYDRICHAIGVVFSSVDRLGKSF---------------IRSAEPAASSSLQELLANSPGA 249
            .:                   |..|:::               ::.||..||.|    ..||...
  Rat   660 RK-------------------DAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS----ATNSNNH 701

  Fly   250 LNKEQLR--------------TLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDD 300
            |.:.|:|              .|||.  ||....:.|   .::.:|..:...|..:..:|:
  Rat   702 LVEPQIRRPRSLSSPTVTLSAPLEGA--KDSPIRRAV---KDTLSNPQSPQPSPYNSPKPQ---- 757

  Fly   301 DVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICF 365
                                             .|:|.|         ::...||..|......|
  Rat   758 ---------------------------------HKVTQS---------FLPPGWEMRIAPNGRPF 780

  Fly   366 DLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITL-- 428
            .:..||..:..:.       |:|     ..||..:::     |:...:.|..|....:::|.|
  Rat   781 FIDHNTKTTTWED-------PRL-----KFPVHMRSK-----ASLNPNDLGPLPPGWEERIHLDG 828

  Fly   429 ---------QVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGS 484
                     |||..|...||:                             |||
  Rat   829 RTFYIDHSSQVLCGENDTRES-----------------------------VPL------------ 852

  Fly   485 AAVEDDLFVYNSLLEPHMPKFAEDQFE-KELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLS 548
                     |:|.:         .|:| ..||..||  ..|.:|        .|...:..:||..
  Rat   853 ---------YDSKI---------TQWEDPRLQNPAI--TGPAVP--------YSREFKQKYDYFR 889

  Fly   549 YKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQE 613
             |.|...::|    .|.|...|:                 |..::.|.|..:.|:
  Rat   890 -KKLKKPADI----PNRFEMKLH-----------------RNNIFEESYRRIMSV---------- 922

  Fly   614 DNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEE 678
              .|||:                           ||.:|.:||..|:|:|.|||::|:|.|:.:|
  Rat   923 --KRPDV---------------------------LKARLWIEFESEKGLDYGGVAREWFFLLSKE 958

  Fly   679 IFNPAFGMFIQQEETNNMWFNATPFENG-------AQFTLIGIIIGLAIYNNVTLAVNFPMVVYR 736
            :|||.:|:| :...|:|......| .:|       :.||.||.:.|||:::...|...|....|:
  Rat   959 MFNPYYGLF-EYSATDNYTLQINP-NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 1021

  Fly   737 KLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVF---EQTFKISYSDVFGDVVQHELVPNG 798
            .::|...|..|:.......|.|||.:|:....:::.:|   |:.        ||...|.:|.|||
  Rat  1022 MMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN--------FGQTYQVDLKPNG 1078

  Fly   799 QDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKL--LFRPEEIEMLVCGSR 861
            .:::|...||..:::|...:.....:::|.|||.:||   |:..|:.|  :|...|:|:|:||..
  Rat  1079 SEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF---TELLPIDLIKIFDENELELLMCGLG 1140

  Fly   862 EFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL----- 921
            :.|..:....::|:.||......||.||..|..|.:|.:.:||:|.||::|||:.|...|
  Rat  1141 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 1205

  Fly   922 -RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
             :|.........::||.:|||||.|.||.|.:.|.|.|:|:.|:..::||
  Rat  1206 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	6/53 (11%)
		HECTc	620..971	CDD:238033	110/369 (30%)
		HECTc	647..970	CDD:214523	108/340 (32%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471
		WW	463..489	CDD:395320
		WW	653..682	CDD:395320	4/47 (9%)
		WW	766..796	CDD:238122	7/36 (19%)
		WW	815..865	CDD:197736	16/108 (15%)
		HECTc	926..1255	CDD:214523	109/368 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810