Protein Alignment Ube3a and Hecw1

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_017455974.1
• Gene: Hecw1 / 291209
• RGDID: 1561038
• Length: 1603
• Species: Rattus norvegicus
• Alignment Length: 1211
• Identity: 259/1211 - (21%)
• Similarity: 436/1211 - (36%)
• Gaps: 341/1211 - (28%)

  Fly     2 NGGG------GGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANC 60
            ||.|      .|:|::...|||:......| :..||:...|.......:......:.|.||.|..
  Rat   493 NGAGEEEMQEKGKDEEEEEGVSALEQGEPG-LELRASVRKKSRPCSLPVSELETVIASACGEAET 556

  Fly    61 SNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAF---TSEANSPQDVDMLSPNDSSSSSSGS 122
            ...:......:....|:  |.|......:||...|:.   :||.:...:||.::.:..|.....:
  Rat   557 PRTHYIRIHTLLHSMPS--AQRGSTTEEEDAMEEESTLKESSEKDGLSEVDTIAADPQSMEDGEN 619

  Fly   123 STSTITSASTTTT------------TSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHS--SG 173
            :.:|:..||:..:            ..:..::.|:......|||.          .||:||  ..
  Rat   620 NGATLCMASSDCSGGHFSNLSKSIGAGQDGEAHPSTGSESDSSPQ----------QGADHSCEGC 674

  Fly   174 DSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICH------AIGVVFSSVD--RLGKSFIRS 230
            |:..|:|:   .:|....|     ..|.::..|...|:      |....|||||  ::.:|.:.|
  Rat   675 DASCCSPS---CYSTSCYS-----SSCYSSSCYSSSCYNGNNRFASHTRFSSVDSAKISESTVFS 731

  Fly   231 A---EPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQV----DEQSESAANATATAES 288
            :   |...:|:.:.:    |.::...:|         |.:||...    ||.:....||..|.|.
  Rat   732 SQEDEEEENSAFESV----PDSVQSPEL---------DPESTNGAGPWQDELAAPGGNAARTTEG 783

  Fly   289 VESE-AEPEEEDDDVCSS-QSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMR 351
            ::|. |.|....:..|.. .:|..:..||.||....     ....|.|.|.
  Rat   784 LDSPMAGPSNRREGDCPMLHNSQPISQLPSLRPEHH-----HYPTIDEPLP-------------- 829

  Fly   352 TDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLH 416
            .:||..|           :::..|..:|:::|.  ...|..|..|.|  ..:.|..:.|..:||:
  Rat   830 PNWEARI-----------DSHGRVFYVDHVNRT--TTWQRPSMAPTP--DGMIRSGSVHQMEQLN 879

  Fly   417 SLIAACQQQITLQVLLDE-----------------------ESMREN-----ESIIS------VT 447
            ......|:.|..:...::                       ||.:.|     |..:|      ||
  Rat   880 RRYQNIQRTIATERSEEDSGNQSCEQIPDGGAGGGGSDSEAESSQSNLDLRREGSLSPVNSQKVT 944

  Fly   448 KVLK-------------IVFYANILASELERPS-C--RVPLEDRTEAATASGSAAVEDDLFVYNS 496
            .:|:             .|.:||..|..:...| |  .:.|:.|.:|...        :.:.:|.
  Rat   945 LLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNF--------ERYQHNR 1001

  Fly   497 LLEPHMPKFAEDQFE--------------------KELQVSAIDCRKPLIPLEEFYNEALSENI- 540
            .|...:..||:.:.|                    .....:.||   |.|||:   |..|..::
  Rat  1002 DLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFID---PRIPLQ---NGRLPNHLT 1060

  Fly   541 -QMHHDYLSYKTLAMESEIG----------SGHANY---------------FSFMLYAFILTPST 579
             :.|...|...:....||:.          .||:..               ::..:.||:..|:.
  Rat  1061 HRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLIAAIRSQHQHESLPLAYNDKIVAFLRQPNI 1125

  Fly   580 KVDALYYDSRMRMYSERYSSL---HSILNNIGQVGQEDN-------------------------- 615
                      ..|..||..||   |::...|..:..|.|
  Rat  1126 ----------FEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSY 1180

  Fly   616 ------------------------------------PRP-------------------------- 618
                                                |.|
  Rat  1181 VPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPG 1245

  Fly   619 DLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPA 683
            .:||.:|||.|:....  .:::|.|..:..:.:|.:.||||:|:|..|.|:|||.|:.:|:|||.
  Rat  1246 KIKLIIRRDHLLEGTF--NQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPY 1308

  Fly   684 FGMFIQQEETNNMWFNATPF----ENGAQ-FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCG 743
            :|:| :....:......:|.    ||..: |...|.|:|||:.:...|...|....|:.|:....
  Rat  1309 YGLF-EYSANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLKLPC 1372

  Fly   744 TFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNK 808
            ..:||.......::||:.|.|   .::.::.:.||.:: .:|||.|.:.||...|.:..|.:.||
  Rat  1373 DLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVN-EEVFGQVTERELKSGGANTQVTEKNK 1433

  Fly   809 ELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTV 873
            :.::.....:.:...:.||..|..:||..|.| |.|..:|...|:|:::.|:.|.|..:..|:|.
  Rat  1434 KEYIERMVKWRVERGVVQQTEALVRGFYEVVD-SRLVSVFDARELELVIAGTAEIDLNDWRNNTE 1497

  Fly   874 YEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL-------RLLITRHGPD 931
            |.|||.:....|:.||:.|....:|.:.:||:|.||::.||..|...|       |..|.:.|..
  Rat  1498 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKI 1562

  Fly   932 SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            :. ||.:|||||.|.||.|.|...|.|:|:.|:..:..||:
  Rat  1563 TS-LPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETSTFGL 1602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	9/53 (17%)
		HECTc	620..971	CDD:238033	112/362 (31%)
		HECTc	647..970	CDD:214523	104/334 (31%)
Hecw1	XP_017455974.1	HECW_N	66..185	CDD:293170
		C2_NEDL1-like	206..342	CDD:176073
		WW	827..857	CDD:197736	8/56 (14%)
		WW	1017..1048	CDD:197736	3/33 (9%)
		HECTc	1247..1601	CDD:238033	112/362 (31%)
		HECTc	1271..1600	CDD:214523	104/335 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810