Protein Alignment Ube3a and HERC4

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_011537894.1
• Gene: HERC4 / 26091
• HGNCID: 24521
• Length: 1081
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 203/662 - (30%)
• Similarity: 317/662 - (47%)
• Gaps: 112/662 - (16%)

  Fly   369 TNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLD 433
            |.|..|.|||:                    .|||.          .|.||.....||:.||...
Human   475 TGTRFSGVDMN--------------------AARLL----------FHKLIQPDHPQISQQVAAS 509

  Fly   434 EESMRENESIISVTKVLKIVFYANILASELERPSCRVPL----EDRTEAATASGSAAVEDD---- 490
            .|.....:...|:..|..:.||       |..|.|  ||    .:.|..|...|:|.|..:
Human   510 LEKNLIPKLTSSLPDVEALRFY-------LTLPEC--PLMSDSNNFTTIAIPFGTALVNLEKAPL 565

  Fly   491 --LFVYNSLLEPHMPKFAE-DQFEKELQVSAIDCRK----------------------------- 523
              |..:.|:|||  |.|.: .:..||:.|..:...|
Human   566 KVLENWWSVLEP--PLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVN 628

  Fly   524 ----PLIPLEEFYNEALSENIQMHHDYLSY-KTLAMESEIGSGHANY----FSFMLYAFILTPST 579
                .:|..::||...:.|.|.:.:||::: :..|...::..|....    .:...|.|:.....
Human   629 EKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQA 693

  Fly   580 KVDALYYDSRMRM-------YSERYSSLH-SILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIG 636
            |...|..|:.::|       :.:..|||. .::.::         .|.|.|.|||:.::.||
Human   694 KTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESV---------NPCLILVVRRENIVGDA--- 746

  Fly   637 LEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNAT 701
            :|::..:...|.||.|.|.||||..:|.|||.||||.||:.|:.:|.:|||...|::..:||:..
Human   747 MEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDK 811

  Fly   702 PFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQ 766
            .||:...|.|||:|.||||||...:.::||:.:|:||:....:..||.:..|.:.:|::.:|||.
Human   812 TFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYP 876

  Fly   767 GQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAF 831
            ..|:||.|...|.|:..: ||.....|||.||.|..|.:.|::.||:.|.|::.|.::...|:||
Human   877 EDDIEETFCLNFTITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAF 940

  Fly   832 RKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMP 896
            ..||..|.....| |||:|.|::.:|.|:..:|:.|||.:|.|:|.|..:...|:.||.:.|.:|
Human   941 HAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELP 1004

  Fly   897 SEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLM 961
            .|.|.:.|.|.|||.|:|:.|:|.|:|:|...|...:.||.||||||:|.||:|:.:|.|..:|:
Human  1005 LEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLI 1069

  Fly   962 KAINYSKGFGML 973
            :||::::||.::
Human  1070 QAIDHNEGFSLI 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	141/350 (40%)
		HECTc	647..970	CDD:214523	132/322 (41%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
		HECTc	733..1079	CDD:238033	141/350 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820