DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and WWTR1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001161750.1	Gene:	WWTR1 / 25937	HGNCID:	24042	Length:	400	Species:	Homo sapiens

Alignment Length:	245	Identity:	49/245 - (20%)
Similarity:	77/245 - (31%)	Gaps:	80/245 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PGVSSASGSAAGAVGGRATPEMKRSAVRS---LIKRYFHQLQ---SGCGNANCSNANCASSGKVA 72
            |.|||             ||..:||...|   |:..:.||.|   |.....|....|..:.....
Human   170 PAVSS-------------TPVPQRSMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSM 221

  Fly    73 P-------------------MTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSS 118
            |                   |....:..|..:|..|:|.||...      |.:.:.|:|   ..:
Human   222 PNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQL------PMEAETLAP---VQA 277

  Fly   119 SSGSSTSTITSASTTTTTS----------RQSQSTPAAV-----VVPVSSPYLTQSVPQLDIAGA 168
            :....|.|....|.|..:|          .:.|||.:.:     .||.:......:|.::|..
Human   278 AVNPPTMTPDMRSITNNSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTG-- 340

  Fly   169 EHSSG--------------DSEPCTP-TLAPVHSLDANSLIALYEQCRAA 203
             .::|              |...|.| |...:.:|::..||.|:....:|
Human   341 -ENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	14/78 (18%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
WWTR1	NP_001161750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..117
		WW	125..156	CDD:197736
		Required for interaction with PALS1. /evidence=ECO:0000269\|PubMed:21145499	222..400		33/180 (18%)
		PDZ-binding	394..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900