DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and mug30

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_596534.1	Gene:	mug30 / 2541379	PomBaseID:	SPBP8B7.27	Length:	807	Species:	Schizosaccharomyces pombe

Alignment Length:	754	Identity:	208/754 - (27%)
Similarity:	337/754 - (44%)	Gaps:	166/754 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 LFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKL 388
            |.|.||:.......|..|.:..:|        ..||.......||.....:|
pombe   114 LSGSQIKTKASTDGSQFISVEHFV--------ETIHQTRSALQLAKQRTGNV------------- 157

  Fly   389 CQAASAMPVPAQARLARIWAA------------HCSDQL----HSLIAACQQQIT-LQVLLDEES 436
             ||..|..:|.:..::.::.:            .||.|.    :.||......|| |.:|:..|.
pombe   158 -QAIVAAGLPLRELISLVFGSPPILNKLFSVKNGCSIQSSGLNYKLIYQLYHDITNLDILITNEL 221

  Fly   437 MRENESIISVTKVLKIVFYAN------ILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYN 495
            :|..||::.     :.:.|.:      .|...||.|.    |..:::......|:.::..|.|.:
pombe   222 LRAIESLLR-----RPMLYCHDPADYQYLLILLENPL----LNSKSKNIVNKSSSILKRILGVLS 277

  Fly   496 SLLEP--------------HMPKFAE---DQFEK-----------------------ELQVSAI- 519
            :|.|.              :.|||..   |...|                       :::.:||
pombe   278 NLNEKTHHFFISCFKKQPYNNPKFFRRKVDLINKFIGQRLMETYSRNKRKHYYNNDWQIKSAAIT 342

  Fly   520 -------DCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTP 577
                   :.:..||....||. .:::.|.::||:          |:.....|.|.|..|.|:|:.
pombe   343 MALLYSANSQMRLIDRSSFYC-IMADFINLYHDF----------ELWEQKINCFCFCQYPFLLSM 396

  Fly   578 STKVDALYYDSRMRM-YSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVA 641
            ..|:..|..|:|.:| ...|.:...|||:.:       |..|.|.:.||||:|:.|:|..:.
pombe   397 GAKISILQLDARRKMEIKAREAFFSSILSKM-------NVEPYLMIRVRRDRLLEDSLRQIN--- 451

  Fly   642 MSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNN-MWFNATPFEN 705
             ...||.:|.|.|||:||:|||.||:.:|:..|:..::|:|.||:|:..||::| :|||   :.:
pombe   452 -DRNKDFRKALKVEFLGEEGIDAGGLKREWLLLLTRKVFSPEFGLFVNCEESSNYLWFN---YSH 512

  Fly   706 GAQ----FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQ 766
            .::    :.:.||::|:||:|::.|.|..|...|:||:....:|.||.|:.|:||:.||.:|.::
pombe   513 RSKEIDYYHMSGILMGIAIHNSINLDVQMPRAFYKKLLQLPLSFNDLDDFQPSLYRGLKELLLFE 577

  Fly   767 GQDMEEVFEQTFKISYSDV--FGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFN 829
            | |::..:...|.|:...|  |..|   ||...|.::.|...|::.:|..|.|:||||.:::||:
pombe   578 G-DVKNTYGLNFTINLKAVEGFRTV---ELKEGGSELSVDNENRKEYVLRYVDYLLNTTVKKQFS 638

  Fly   830 AFRKGFEMVTDESPLKLLFRPEEIEMLVCGSRE-FDFVELENSTVYE------------------ 875
            ||..||..|...:.:. ||:..||..|:.||.| .|:..|:|..||:
pombe   639 AFFDGFMKVCGGNAIS-LFQDNEISKLIRGSEEVIDWELLKNVCVYDFYDQNAISNSISESEPSM 702

  Fly   876 -------GGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSD 933
                   ..:..|.:.|..||.::.....:.:...|.|.|||.|:|..|....:|.|:..|||||
pombe   703 TASKYLCHSFVSKRKIILWFWDLISHYSLKMQKLFLIFVTGSDRIPATGAHNFQLRISVLGPDSD 767

  Fly   934 RLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            :||.||||||.|.:.||||||||:::|..|:..:.||.:
pombe   768 QLPISHTCFNHLCIWEYSSREKLKKKLDTALLETNGFNI 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	135/383 (35%)
		HECTc	647..970	CDD:214523	125/355 (35%)
mug30	NP_596534.1	HUL4	1..807	CDD:227354	208/754 (28%)
		ZnF_UBP	100..152	CDD:197632	11/45 (24%)
		HECTc	433..804	CDD:238033	134/382 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	187	1.000	Domainoid score	I755
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47228
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.670