DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ube3a and NEDD4L

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:XP_006722489.1 Gene:NEDD4L / 23327 HGNCID:7728 Length:1019 Species:Homo sapiens


Alignment Length:977 Identity:217/977 - (22%)
Similarity:343/977 - (35%) Gaps:355/977 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 ASSG-KVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITS 129
            ||.| :.:|...:|..:|.||:           |.::|..|         .||......:|.:.|
Human   322 ASPGSRTSPQELSEELSRRLQI-----------TPDSNGEQ---------FSSLIQREPSSRLRS 366

  Fly   130 ASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSS---GDSEPCTPTLAPVHSLDAN 191
            .|.|...:.|..      :.|.|:|           ||...||   |..|| ||::|.||:  ..
Human   367 CSVTDAVAEQGH------LPPPSAP-----------AGRARSSTVTGGEEP-TPSVAYVHT--TP 411

  Fly   192 SLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSF---------------IRSAEPAASSSLQE 241
            .|.:.:|:.:                   |..|:::               ::.||..||.|   
Human   412 GLPSGWEERK-------------------DAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS--- 454

  Fly   242 LLANSPGALNKEQLR--------------TLEGEHDKD-----EDSTQQVDEQSESAANATATAE 287
             ..||...|.:.|:|              .|||..|..     :|:.........|..|:.....
Human   455 -ATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 518

  Fly   288 SV---------ESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQL 343
            .|         |....|......:..:..:.|..|       .||.|...:|:.|....:.:..|
Human   519 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWED-------PRLKFPVHMRSKTSLNPNDLGPL 576

  Fly   344 SDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMD----YLDRVLPKLCQAASAMPVPAQARLA 404
            .       ..||..||                  :|    |:|                      
Human   577 P-------PGWEERIH------------------LDGRTFYID---------------------- 594

  Fly   405 RIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCR 469
                 |.|                |||..|...|  ||:.|....:          ::.|.|   
Human   595 -----HSS----------------QVLCGENDTR--ESVPSYDSKI----------TQWEDP--- 623

  Fly   470 VPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAE--DQFEKELQVSAIDCRKPL-IPLEEF 531
                 |.:....:|.|.             |:..:|.:  |.|.|:|       :||. ||    
Human   624 -----RLQNPAITGPAV-------------PYSREFKQKYDYFRKKL-------KKPADIP---- 659

  Fly   532 YNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSER 596
                                            |.|...|:                 |..::.|.
Human   660 --------------------------------NRFEMKLH-----------------RNNIFEES 675

  Fly   597 YSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQG 661
            |..:.|:            .|||:                           ||.:|.:||..|:|
Human   676 YRRIMSV------------KRPDV---------------------------LKARLWIEFESEKG 701

  Fly   662 IDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENG-------AQFTLIGIIIGLA 719
            :|.|||::|:|.|:.:|:|||.:|:| :...|:|......| .:|       :.||.||.:.|||
Human   702 LDYGGVAREWFFLLSKEMFNPYYGLF-EYSATDNYTLQINP-NSGLCNEDHLSYFTFIGRVAGLA 764

  Fly   720 IYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVF---EQTFKIS 781
            :::...|...|....|:.::|...|..|:.......|.|||.:|:....:::.:|   |:.    
Human   765 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN---- 825

  Fly   782 YSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKL 846
                ||...|.:|.|||.:::|...||..:::|...:.....:::|.|||.:||   |:..|:.|
Human   826 ----FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF---TELLPIDL 883

  Fly   847 --LFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTG 909
              :|...|:|:|:||..:.|..:....::|:.||......||.||..|..|.:|.:.:||:|.||
Human   884 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTG 948

  Fly   910 SARVPVGGLKCL------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSK 968
            ::|||:.|...|      :|.........::||.:|||||.|.||.|.:.|.|.|:|:.|:..::
Human   949 TSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 1013

  Fly   969 GF 970
            ||
Human  1014 GF 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 8/28 (29%)
HECTc 620..971 CDD:238033 110/369 (30%)
HECTc 647..970 CDD:214523 108/340 (32%)
NEDD4LXP_006722489.1 C2_NEDD4_NEDD4L 21..179 CDD:175999
WW 224..250 CDD:278809
WW 413..442 CDD:278809 4/47 (9%)
WW 526..556 CDD:238122 4/36 (11%)
WW 575..625 CDD:197736 20/137 (15%)
HECTc 662..1016 CDD:238033 119/423 (28%)
HECTc 686..1015 CDD:214523 109/368 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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