Protein Alignment Ube3a and HECW1

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_016867371.1
• Gene: HECW1 / 23072
• HGNCID: 22195
• Length: 1639
• Species: Homo sapiens
• Alignment Length: 1096
• Identity: 250/1096 - (22%)
• Similarity: 424/1096 - (38%)
• Gaps: 261/1096 - (23%)

  Fly     5 GGGEDDQHLPGVSSASGSA---------AGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANC 60
            |..:|....|...|.|.|:         .|......:|....|:..|.     ....|.|.:|:|
Human   676 GAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYST-----SCYSSSCYSASC 735

  Fly    61 SNANCASSGKVAPMT-----PNEVAARALQLFSQDAQLCE--AFTSEANSPQDVDMLSPNDSSSS 118
            .:.:|.:..:.|..|     .:...:.:....|||.:..|  ||.|..:|     |.||.....|
Human   736 YSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDS-----MQSPELDPES 795

  Fly   119 SSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSP-----------YLTQSVPQLDIAGAEHSS 172
            ::|:.......|:.:....|    :|..:..||:.|           :.:|.|.||.....||..
Human   796 TNGAGPWQDELAAPSGHVER----SPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHH 856

  Fly   173 GDS--EPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAA 235
            ..:  ||..|.               :|  ...||:.|:.:        ||.:.::.......||
Human   857 YPTIDEPLPPN---------------WE--ARIDSHGRVFY--------VDHVNRTTTWQRPTAA 896

  Fly   236 --------SSSLQELLANSPGALNKEQL--------RTLEGEHDKDEDSTQQVDEQSESAANATA 284
                    |.|:|::          |||        ||:..|. .:|||..|..||:.:......
Human   897 ATPDGMRRSGSIQQM----------EQLNRRYQNIQRTIATER-SEEDSGSQSCEQAPAGGGGGG 950

  Fly   285 TAESVESEAEPEEEDDDV--------CSSQSSDTLVDLPGLRRVQRLLFGCQIRA---ITEKLTS 338
            .:   :||||..:...|:        .:||....|:..|.::.:....|...:.|   .....||
Human   951 GS---DSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTS 1012

  Fly   339 SVIQLSDWVIYMRTD---WERVIHC----------------LVICFDLATNTNNSVVDMDYLDR- 383
            |.. |...::.:|.|   :||..|.                |...:::.|:.......:|:..|
Human  1013 STC-LKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRA 1076

  Fly   384 ---VLPKLCQAASAMP--VPAQARLARI--WAAHCSDQL-------------HSLIAACQQQITL 428
               :.|::......:|  :..:..|.|:  ::|..:.::             |||:||.:.|
Human  1077 TTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQ--- 1138

  Fly   429 QVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFV 493
                     .::||       |.:.:...|:|. |.:|:....|::|..
Human  1139 ---------HQHES-------LPLAYNDKIVAF-LRQPNIFEMLQERQP---------------- 1170

  Fly   494 YNSLLEPH--MPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMES 556
              ||...|  ..|....:.|....:..:.|...|:.|...:.|          :.:||..|....
Human  1171 --SLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEE----------EIMSYVPLQAAF 1223

  Fly   557 EIGSGHANYFSFMLYAF---------------ILTPSTKVDALY---YDSRMRMYSERYSSLHSI 603
            ..|           |:|               :...|.:..:.|   :::::|.:   |..|.:
Human  1224 HPG-----------YSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNF---YRKLEA- 1273

  Fly   604 LNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVS 668
             ...||     .| ..:||.:|||.|:....  .:::|.|..:..:.:|.|.||||:|:|..|.|
Human  1274 -KGFGQ-----GP-GKIKLIIRRDHLLEGTF--NQVMAYSRKELQRNKLYVTFVGEEGLDYSGPS 1329

  Fly   669 KEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF----ENGAQ-FTLIGIIIGLAIYNNVTLAV 728
            :|||.|:.:|:|||.:|:| :....:......:|.    ||..: |...|.|:|||:.:...|..
Human  1330 REFFFLLSQELFNPYYGLF-EYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDA 1393

  Fly   729 NFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHE 793
            .|....|:.|:......:||.......::||:.|.|   .::.::.:.||.:: .:|||.|.:.|
Human  1394 FFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVN-EEVFGQVTERE 1454

  Fly   794 LVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVC 858
            |...|.:..|.:.||:.::.....:.:...:.||..|..:||..|.| |.|..:|...|:|:::.
Human  1455 LKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVD-SRLVSVFDARELELVIA 1518

  Fly   859 GSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL-- 921
            |:.|.|..:..|:|.|.|||.:....|:.||:.|....:|.:.:||:|.||::.||..|...|
Human  1519 GTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRG 1583

  Fly   922 -----RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
                 |..|.:.|..:. ||.:|||||.|.||.|.|...|.|:|:.|:..:..||:
Human  1584 SNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	11/58 (19%)
		HECTc	620..971	CDD:238033	113/362 (31%)
		HECTc	647..970	CDD:214523	105/334 (31%)
HECW1	XP_016867371.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810