DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Hectd2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001156943.1	Gene:	Hectd2 / 226098	MGIID:	2442663	Length:	775	Species:	Mus musculus

Alignment Length:	845	Identity:	246/845 - (29%)
Similarity:	384/845 - (45%)	Gaps:	180/845 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SSSLQELLANSP---GALNKEQLRTLEGEHDK-------------DEDSTQQVDEQSESAANATA 284
            |.:.::|...:|   .|...|:.:..|.|.:|             |..|..|:...|...:..|.
Mouse     2 SEAARDLSPGAPPAVAAAAPEERKGKEPEREKLPPIVTAGAAAGLDRGSKGQISTFSSFVSTVTQ 66

  Fly   285 TAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGC-----QIRAITEKLTSSV---- 340
            ..|:.|              ::||.|.:.||.:|.|:.|...|     :.|...|.|.|.|
Mouse    67 KKEAAE--------------NRSSPTHLALPNIRNVRDLPPICLDVRQKQRMSVEALPSEVKVPP 117

  Fly   341 -------------------IQLSDWVIYMRTDWERVIHCLVICFDLATNTN-----------NSV 375
                               ::.::    ...:|:.|....:..||..|..|           |::
Mouse   118 LPEPSLPSQPKTVKDFEEDLEKAE----ATGNWKTVHAFYITAFDSFTELNTAFKKDATASFNTI 178

  Fly   376 VDMDYLDRVLPKLCQAASAMPVPAQA--------RLARIW-AAHCSDQLHS---LIAACQQQITL 428
            .|......::..:..|....|...|.        .|.:.| .....|.|.:   |:...|..||.
Mouse   179 EDSGLNANLVNAVFDALLNTPQDIQKSVLKGIINSLLQEWKGPRTKDDLRAYFILLQNPQFNITS 243

  Fly   429 QVLLDEESMRENESIIS---------------------VTKVLKIVFYANILASELERPSCRVPL 472
            ..::....:|:..:::.                     |.::|:.|......|...|.|    ||
Mouse   244 TYVIYAHLLRQIATLVEADHHFLVHWLKKLSQKKFKQLVERLLQFVSLRLFPAKPEEFP----PL 304

  Fly   473 EDRTEAATASGSAA-VEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEAL 536
               |:......||| |...|...|:|:.|                       ||:|..:|||..|
Mouse   305 ---TKCTWWIPSAAKVLALLNTANNLVHP-----------------------PLVPYTDFYNSTL 343

  Fly   537 SENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLH 601
             ::|.:..:|.::::      .|:.|:. |||..|.|:::.:.|...:..||..:|.|....||
Mouse   344 -DHIDLMEEYHTWQS------FGNSHSR-FSFCQYPFVISIAAKKIIIQRDSEQQMISIARQSL- 399

  Fly   602 SILNNIGQVGQEDNPRPD-----LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQG 661
                 :.:|.:..  |||     |.:.|||..|::|:|..|    .....||||:|.|.||||.|
Mouse   400 -----VDKVSRRQ--RPDMNMLFLNMKVRRTHLVSDSLDEL----TRKRADLKKKLKVTFVGEAG 453

  Fly   662 IDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTL 726
            :|.||::||:|.|::.:||:|.:|||...::::..||::...:|.::|.|:||::|||:||::||
Mouse   454 LDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITL 518

  Fly   727 AVNFPMVVYRKL-------------IGYCG-TFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQT 777
            .:.||...|:||             :|.|. |..||....|.|...||.:|.|:| ::||.|..|
Mouse   519 DIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDLCQVMPELAHGLKELLSYEG-NVEEDFYST 582

  Fly   778 FKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDES 842
            |:: :.:.||.:..:.|.|.|..:.|...|:..:|.||:|||||.:|.:||.||..||..|...:
Mouse   583 FQV-FQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASN 646

  Fly   843 PLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFT 907
            .|.|| ||||:|:|||||.|.|...|:.||.|: ||.:....|:.||.:|...|.|.:.|||.||
Mouse   647 ALMLL-RPEEVEILVCGSPELDMHALQRSTQYD-GYAKTDLTIRYFWDVVLGFPLELQKKLLHFT 709

  Fly   908 TGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            |||.||||||:..|...|:::...::.||.:|||||.|.||.|.|::.|:::|:..|:.|:|||:
Mouse   710 TGSDRVPVGGMADLNFKISKNETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 774

Fly 973 972
Mouse 775 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	151/364 (41%)
		HECTc	647..970	CDD:214523	142/336 (42%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		9/48 (19%)
		HECTc	416..773	CDD:238033	151/364 (41%)
		HECTc	439..772	CDD:214523	142/336 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720