DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Yap1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_006509915.1	Gene:	Yap1 / 22601	MGIID:	103262	Length:	494	Species:	Mus musculus

Alignment Length:	487	Identity:	98/487 - (20%)
Similarity:	165/487 - (33%)	Gaps:	192/487 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ANSPQDVDM---------LSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSP-- 154
            ||.||.|.|         ..|.:..|.|..:||...|:.:.|....| :.|:||::.:...||
Mouse    63 ANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVR-AHSSPASLQLGAVSPGT 126

  Fly   155 -----------------YLTQS---VPQLDI---AG---AEHSSGDSEPCTPTLAPVHSLDANSL 193
                             :|.||   :|. |:   ||   |:.|||..          :.|:.|..
Mouse   127 LTASGVVSGPAAAPAAQHLRQSSFEIPD-DVPLPAGWEMAKTSSGQR----------YFLNHNDQ 180

  Fly   194 IALYEQCRAA----------------------------DSYDRICHAIGVVF---------SSVD 221
            ...::..|.|                            |.:::.....|.|:         |.:|
Mouse   181 TTTWQDPRKAMLSQLNVPAPASPAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTSWLD 245

  Fly   222 -----RLGKSF---------IRSAEPAASSSLQELLANSPGALNKE---QLRTLEGEHD----KD 265
                 |.||:.         ::...|.|..|.|..:... |:.|::   ||:.|:.|.:    |.
Mouse   246 PRLDPRFGKAMNQRITQSAPVKQPPPLAPQSPQGGVLGG-GSSNQQQQIQLQQLQMEKERLRLKQ 309

  Fly   266 EDSTQQVDEQ-----SESAANATATAE-SVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLL 324
            ::..:||..|     :.|.|||....| ::.|:....|:|....::.||      ||:.:
Mouse   310 QELFRQVRPQAIRNINPSTANAPKCQELALRSQLPTLEQDGGTPNAVSS------PGMSQ----- 363

  Fly   325 FGCQIRAIT----------------EKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNN 373
               ::|.:|                ::.|.|.:.:|.:.|....|                :..|
Mouse   364 ---ELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSIPRTPD----------------DFLN 409

  Fly   374 SVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSL----------------IAAC 422
            ||.:||..|.:        |...:|:|       .:...|.|.:|                |...
Mouse   410 SVDEMDTGDTI--------SQSTLPSQ-------QSRFPDYLEALPGTNVDLGTLEGDAMNIEGE 459

  Fly   423 QQQITLQVLLDEESMRENESIISVTKVLKIVF 454
            :...:||..|..|.: :.||:::.||:.|..|
Mouse   460 ELMPSLQEALSSEIL-DVESVLAATKLDKESF 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	19/78 (24%)
		WW	159..188	CDD:238122	8/38 (21%)
		WW	217..246	CDD:366073	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900