Protein Alignment Ube3a and Ube3a

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_035798.2
• Gene: Ube3a / 22215
• MGIID: 105098
• Length: 870
• Species: Mus musculus
• Alignment Length: 1005
• Identity: 393/1005 - (39%)
• Similarity: 563/1005 - (56%)
• Gaps: 188/1005 - (18%)

  Fly    14 PGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSGKVAPMTPNE 78
            ||.|.:....|.        .|||:|.:.||:||:|||..||||..|:|..|||......|..|.
Mouse     9 PGESQSEDIEAS--------RMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNA 65

  Fly    79 VAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTS----RQ 139
            .|.:||:|:..:|:||                   |...|..|:|::.:.::...:..|    .:
Mouse    66 AAIKALELYKINAKLC-------------------DPHPSKKGASSAYLENSKGASNNSEIKMNK 111

  Fly   140 SQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAAD 204
            .:......|:     |||:                                ..:..:||.||.::
Mouse   112 KEGKDFKDVI-----YLTE--------------------------------EKVYEIYEFCRESE 139

  Fly   205 SYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDST 269
            .|..:...||.:|||.:.|..||.:..:.                 .||:|::|:   :||||..
Mouse   140 DYSPLIRVIGRIFSSAEALVLSFRKVKQH-----------------TKEELKSLQ---EKDEDKD 184

  Fly   270 QQVDEQSESAANATATAESVESEA----EPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIR 330
            :  ||:.::|.:|.|..|..|:.:    :..:.|::|......|..||:..:|||...|..
Mouse   185 E--DEKEKAACSAAAMEEDSEASSSRMGDSSQGDNNVQKLGPDDVTVDIDAIRRVYSSLLA---- 243

  Fly   331 AITEKLTSSVIQLSDWVIYMRTDWE-------------RVIHCLVICFDLATNTNNSVVDMDYLD 382
              .|||.::.:..   ::|:..:.|             ..::..:|..:     |:::...:||:
Mouse   244 --NEKLETAFLNA---LVYLSPNVECDLTYHNVYTRDPNYLNLFIIVME-----NSNLHSPEYLE 298

  Fly   383 RVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMR----ENESI 443
            ..||..|:|...:|:.||.:|.|:|:.:.:||:..::...||.||.:|:.:|.:.|    ::::|
Mouse   299 MALPLFCKAMCKLPLEAQGKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAI 363

  Fly   444 ISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAE- 507
            ::.:|.||:|:|||::..:::        .:..|          |||        |..:|:.:|
Mouse   364 VAASKCLKMVYYANVVGGDVD--------TNHNE----------EDD--------EEPIPESSEL 402

  Fly   508 ------------------DQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAM 554
                              |..|.||.|..:|||||||..|||.||.|::.::|..||..:|   :
Mouse   403 TLQELLGDERRNKKGPRVDPLETELGVKTLDCRKPLISFEEFINEPLNDVLEMDKDYTFFK---V 464

  Fly   555 ESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSE-RYSSLHSILNNIGQVGQEDNPRP 618
            |:|      |.||||...|||...||...||||:|:||||| |.:.|:|::.     ||:.||.
Mouse   465 ETE------NKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQ-----GQQLNPY- 517

  Fly   619 DLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPA 683
             |:|.||||.:|:|||:.|||:||.||.||||||.|||.||||:||||||||||||:|||||||.
Mouse   518 -LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPD 581

  Fly   684 FGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADL 748
            .|||...|.|...|||.:.||...|||||||::|||||||..|.|:|||||||||:|..|||.||
Mouse   582 IGMFTYDEATKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDL 646

  Fly   749 SDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVN 813
            .|..|.||:|||.:|:|:| .:|:....||:||.:|:||:.:.::|..||..:.:...|::.|||
Mouse   647 GDSHPVLYQSLKDLLEYEG-SVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVN 710

  Fly   814 LYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGY 878
            ||||::||.::|:||.|||:||.|||:|||||.||||||||:|:||||..||..||.:|.|:|||
Mouse   711 LYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGY 775

  Fly   879 TEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFN 943
            |.:|..|::||.|||:...|.|...|:||||:.|.|||||..|:::|.::|||::||||||||||
Mouse   776 TRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFN 840

  Fly   944 VLLLPEYSSREKLEERLMKAINYSKGFGML 973
            |||||||||:|||:|||:|||.|:||||||
Mouse   841 VLLLPEYSSKEKLKERLLKAITYAKGFGML 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	23/53 (43%)
		HECTc	620..971	CDD:238033	216/350 (62%)
Ube3a	NP_035798.2	AZUL	27..81	CDD:465173	25/53 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..223		12/51 (24%)
		HECTc	518..868	CDD:238033	197/350 (56%)