DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Wwc1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_740749.1	Gene:	Wwc1 / 211652	MGIID:	2388637	Length:	1104	Species:	Mus musculus

Alignment Length:	353	Identity:	72/353 - (20%)
Similarity:	128/353 - (36%)	Gaps:	88/353 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNGGGGGEDDQHL---PGVSSAS-GSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCS 61
            :|.||.|..:::.   ||..... |.||....|..   :|.:.|.:.:..     :|..|::...
Mouse   579 LNLGGSGTQERYRLEEPGPEGKPLGQAASVAPGCG---LKVACVSAAVSD-----ESVAGDSGVY 635

  Fly    62 NANCASSG--KVAPMTPNE---VAARALQ--------------LFSQDAQLCEAFTSEANSPQDV 107
            .|:....|  :.|....:|   |.|..:|              |..|.:.| .|.:.:.:...::
Mouse   636 EASAQRPGTSEAAAFDSDESEAVGATRVQIALKYDEKNKQFAILIIQLSHL-SALSLQQDQKVNI 699

  Fly   108 DMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSS 172
            .:.....|.||:....|..:.||:|.....        |..|.:|.|.|.|...::|:...:.|
Mouse   700 RVAILPCSESSTCLFRTRPLDSANTLVFNE--------AFWVSISYPALHQKTLRVDVCTTDRS- 755

  Fly   173 GDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAAS- 236
             .:|.|.          ..:.|:|.|.||:.:...|..:.:...:.      |...|..:|..:
Mouse   756 -HTEECL----------GGAQISLAEVCRSGERSTRWYNLLSYKYL------KKQCREPQPTEAP 803

  Fly   237 -----SSLQELLANSPGALNKEQ-----LRTLEGEHDKDEDSTQQVDEQSESAANATATAESVES 291
                 .::..||..:...|.|.|     .:||||....:|::::.                  |:
Mouse   804 GPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASEN------------------EA 850

  Fly   292 EAEPEEE-DDDVCSSQSSDTLVDLPGLR 318
            .||.||| ::||.:.:.|....:.|.|:
Mouse   851 VAEEEEEGEEDVFTEKVSPEAEECPALK 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	12/72 (17%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
Wwc1	NP_740749.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..449
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..547
		C2_Kibra	661..784	CDD:176062	28/143 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..949		19/75 (25%)
		Interaction with histone H3. /evidence=ECO:0000250	836..1104		14/61 (23%)
		Interaction with PRKCZ. /evidence=ECO:0000250	945..988
		ADDV motif	1102..1104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900