Protein Alignment Ube3a and Hace1

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_006512697.1
• Gene: Hace1 / 209462
• MGIID: 2446110
• Length: 921
• Species: Mus musculus
• Alignment Length: 1033
• Identity: 232/1033 - (22%)
• Similarity: 389/1033 - (37%)
• Gaps: 280/1033 - (27%)

  Fly    44 IKRYFHQLQSGCGNANC--------SNANCASSGKVAPMTPNEVAAR--------ALQLFSQDAQ 92
            :||....:.:.||:..|        :|.|...   ::..||..:|||        .|..:|.|..
Mouse    64 VKRSLLHIAANCGSVECLVLLLKKGANPNYQD---ISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

  Fly    93 LC--EAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPY 155
            :|  |..|:       :..|:.|       |.:..........|....:......|:.|...:.:
Mouse   126 ICNNEGLTA-------IHWLAVN-------GRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGH 176

  Fly   156 LTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSV 220
            .|.....|| :||:.:..:....||               ||..||      |:|    ::|.:
Mouse   177 KTTVQCLLD-SGADINRPNVSGATP---------------LYFACR------RVC----LIFWT- 214

  Fly   221 DRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEG-EHDKDEDSTQQVDEQSESAANATA 284
                                  ..:|.|..:..|:..|.| ::..|::....:|...:.....|.
Mouse   215 ----------------------WIHSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGQTC 257

  Fly   285 TA---------ESVESEAEPEEEDDDV-------CSSQS-SDTLVDLPGLRRV-----QRLL--- 324
            ..         :::....:.|:..:::       .|.|| |..|..|.||..|     .:||
Mouse   258 EVLIQYHPRLFQTIVQMTQNEDLRENMLRQVLQHLSQQSESQYLKILTGLAEVATTNGHKLLSLS 322

  Fly   325 --FGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPK 387
              :..|::::.                      |::......|.:..::.::.:||.|.....|:
Mouse   323 SNYDAQMKSLL----------------------RIVRIFCHVFRIGPSSPSNGIDMGYNGNKTPR 365

  Fly   388 LCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKI 452
                 |.:..|    |..:|  |..|:...|||.             |.|:..|....:|.:|
Mouse   366 -----SQVFKP----LELLW--HSLDEWLVLIAT-------------ELMKNKEDSTDITSIL-- 404

  Fly   453 VFYANILASELERPSCRV---------------PLEDRTE--AATASGSAAVEDDLFVYNSLLE- 499
               ......:.|.||...               |.:.:.|  |.....||..:|.:.|..:.|.
Mouse   405 ---LKQKGQDQEAPSLSAFEPPGPGSYESLPPGPGDSKPEVLAGEQEASADCQDVISVTANRLSA 466

  Fly   500 --------------PHM--PKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLS 548
                          |.|  |:|.|...:.:..:.....|.|.|..:.|:
Mouse   467 VIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFH---------------- 515

  Fly   549 YKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSER----YSSLHSILNNIGQ 609
                                    |:|.....:....:..:.:.:.:|    |..|||
Mouse   516 ------------------------FLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHS------- 549

  Fly   610 VGQEDNP---RP----DLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGV 667
             ||.|:.   ||    |: |.|.||.:...:   .|:|:.:|...||:.:.|.|.||:|:.: ||
Mouse   550 -GQPDSDMVHRPVSENDI-LLVHRDSIFRSS---CEIVSKANCAKLKQGIAVRFHGEEGMGQ-GV 608

  Fly   668 SKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQ---FTLIGIIIGLAIYNNVTLAVN 729
            .:|:|.::..||.||.:.:|.|..:......|:..:.|...   |...|.|:|||:.:...:.:.
Mouse   609 VREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIY 673

  Fly   730 FPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHEL 794
            |....|:.::|....:.|::...|...|:|:.:||....|:.  .|.||.:. :||||.:.:..|
Mouse   674 FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLG--LELTFSVE-TDVFGAMEEVPL 735

  Fly   795 VPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG 859
            .|.|..:||.|:||..:|.|.::..:...|:.|.|||.:||.|....|.:: ||...|:|:|:.|
Mouse   736 KPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLSG 799

  Fly   860 SREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVG-------- 916
            ..|.|..:...:|.|..||..:...||.||.:|..:..|::..||:|.|||:|||.|
Mouse   800 MPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 864

  Fly   917 -GLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINY-SKGFGM 972
             ||:...:....:.|  :.||||.||.|:|.||||.|:|.|::||:.|::. |.|:.|
Mouse   865 SGLQNFTIAAVPYTP--NLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTM 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	15/65 (23%)
		HECTc	620..971	CDD:238033	119/363 (33%)
Hace1	XP_006512697.1	ANKYR	26..261	CDD:440430	46/262 (18%)
		ANK repeat	66..95	CDD:293786	6/28 (21%)
		ANK repeat	97..128	CDD:293786	8/30 (27%)
		ANK repeat	130..161	CDD:293786	6/44 (14%)
		ANK repeat	163..194	CDD:293786	7/31 (23%)
		ANK repeat	196..233	CDD:293786	13/84 (15%)
		HECTc	566..915	CDD:238033	117/359 (33%)