DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ube3a and hecd-1

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_001368365.1 Gene:hecd-1 / 177486 WormBaseID:WBGene00016405 Length:2650 Species:Caenorhabditis elegans


Alignment Length:1263 Identity:244/1263 - (19%)
Similarity:413/1263 - (32%) Gaps:505/1263 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSGKVAPMTPN-- 77
            |..|:.||:.||:|      .|..:..:|:    .:.|...|.:..|....||:..:...||:  
 Worm  1583 GTPSSGGSSGGAIG------KKSMSTTNLV----DERQKTSGPSVASTGQAASAESLQHQTPSLE 1637

  Fly    78 EVAARALQLFSQDAQLCEAF--TSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQS 140
            .:.|||:.         .||  .:|...|:|..|......|::|..|:.|:.:..|..:::.:|.
 Worm  1638 NLLARAMP---------HAFGRIAENQEPEDEPMGGEESDSAASMRSAASSNSQMSMGSSSQQQQ 1693

  Fly   141 QSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADS 205
            |..             :...|: |.||.        |.||      ..|.|..:::         
 Worm  1694 QQD-------------SDMTPR-DSAGT--------PSTP------RDDKNQTLSV--------- 1721

  Fly   206 YDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDE---- 266
                                    ||...|::..::..|.:            :|:.|.||    
 Worm  1722 ------------------------SAPDLAAARQRQASAET------------DGDADADETNSE 1750

  Fly   267 ------DSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLF 325
                  |...:.|::.|         |::|.|.:.:::|||..|:::.:.||:|.|   .:|.||
 Worm  1751 DKTVGADDAMEEDDEEE---------ETMEDEEDDDDDDDDESSNENQEKLVELLG---GERGLF 1803

  Fly   326 GCQIRAIT-EKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVD------------ 377
            ......|| |.|:.:.....|                       ..||.:...            
 Worm  1804 DKLKEVITGESLSDASSSAKD-----------------------ATTNEAQKKGGKKPKKWFKKM 1845

  Fly   378 MDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLD--------E 434
            ..|.| ||..|.|  :..||                   :|:......|.:..::|        |
 Worm  1846 SSYTD-VLKGLMQ--NRYPV-------------------ALLDPAAAGIEMDEMMDDDDYYDFSE 1888

  Fly   435 ESMRENESI---ISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGS----AAV----- 487
            :...:.:|:   ::....:.:..:|:::|:       |.|:..|..:...|||    ||:     
 Worm  1889 DGPDDGDSVEDEVAAHLGMPVDSFASMVAA-------RTPITWRQFSELMSGSNRERAAMARAVA 1946

  Fly   488 -------EDDLFV-------------------YNSLLEPHMPKFAEDQFEKELQVSAID------ 520
                   |||..|                   .|..||..:|...:|....:...|.||      
 Worm  1947 SSRGSPWEDDATVKCTFEALIPAFDPRPGRSNVNQTLEVELPTVVKDFGSTKASSSKIDKDDQMR 2011

  Fly   521 --CRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVD- 582
              .|.|        |.:..:|:          |:.|..:..|         |:.::...:..|: 
 Worm  2012 FFLRGP--------NMSGVDNV----------TIEMNDDSAS---------LFRYMQIINNSVNW 2049

  Fly   583 ALYYDSRMRMYSERYS-------------------------SLHSILNNIGQVGQEDNPRPDL-- 620
            |...|...|::...||                         .::..|..||.:.:.....|:.  
 Worm  2050 ATKSDRSRRIWEPTYSICYCSADQTNVEVSKIPDEESSTPCQVNQCLETIGLLSRIQQAMPEAEI 2114

  Fly   621 --------KLTVRRDQLINDALIGLEMVAMSNPK------------------------------- 646
                    |||::..|:::|||:   :.|.|.|:                               
 Worm  2115 TPNVFISDKLTLKVTQVLSDALV---VAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSR 2176

  Fly   647 ----------------------------------------------------------------- 646
                                                                             
 Worm  2177 TIVWLQQRRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLLDQAIRLMK 2241

  Fly   647 ---DLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNM------------ 696
               |.|..|.:|:..|:|... |.:.||:.|:..|:...:..:::..::..:.            
 Worm  2242 FHADRKAVLEIEYTNEEGTGL-GPTLEFYALVAAELQRKSLALWVCDDDDTHASKSGEEREVDLG 2305

  Fly   697 ---------------WFNATPFENGA--------QFTLIGIIIGLAIYNN--VTLAVNFPMVVYR 736
                           .|.| |...|.        .|.::|:.:...:.:.  |.|.::.|   :.
 Worm  2306 EGKKPIGYYVRRVGGLFPA-PLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRP---FL 2366

  Fly   737 KLIGYCGTFADLSDWSPALYKSLKSMLDYQ------GQDMEEV--FEQTFKISYSDVFGD----- 788
            ||:.:.....|..  .|.|:|.| |:.|::      |..::|:  ..|..::..:|...|     
 Worm  2367 KLLVHPQIGDDAR--GPNLHKIL-SLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKR 2428

  Fly   789 -------------------------------VVQH---ELVPNGQDVLVGQHNKELFVNLYSDFL 819
                                           |.|:   |||..|.|:.|...|.|.:|....:|.
 Worm  2429 RKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFY 2493

  Fly   820 LNTNIEQQFNAFRKGFEMVTDESPLKLL--FRPEEIEMLVCGSR--EFDFVELENSTVYEGGYTE 880
            |||.|..|..|||.||:.|   .||:.|  :.|||::.|:.|.:  |:...::.|.|..:.|||.
 Worm  2494 LNTGIAYQMRAFRDGFDRV---FPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTR 2555

  Fly   881 KSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL--RLLITRHGPDSD-RLPTSHTCF 942
            :|.....|..::.|:.::::...|:|.||.:.:|.|||..|  ||.|.|.....| ..|:.:||.
 Worm  2556 ESPGFLRFVDVMEALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCV 2620

  Fly   943 NVLLLPEYSSREKLEERLMKAINYSKGF 970
            :.|.||||||...|.|||:.||| .|||
 Worm  2621 HYLKLPEYSSSAILRERLLTAIN-EKGF 2647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 11/55 (20%)
HECTc 620..971 CDD:238033 118/551 (21%)
HECTc 647..970 CDD:214523 106/413 (26%)
hecd-1NP_001368365.1 Ank_2 345..436 CDD:403870
ANK repeat 345..372 CDD:293786
ANK repeat 374..403 CDD:293786
PTZ00322 383..>497 CDD:140343
ANK repeat 405..436 CDD:293786
F5_F8_type_C 1243..1365 CDD:419973
MIB_HERC2 1452..1509 CDD:399589
HECTc 2221..2648 CDD:238033 108/439 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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