DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and oxi-1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_499392.1	Gene:	oxi-1 / 176515	WormBaseID:	WBGene00003898	Length:	1066	Species:	Caenorhabditis elegans

Alignment Length:	852	Identity:	189/852 - (22%)
Similarity:	330/852 - (38%)	Gaps:	208/852 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 AIGVVFSSVDRL------GKSFIRSAEPAASSSLQELLANSPGAL-----------NKEQLRTLE 259
            |:||..|....|      .|:.:....|.....|..:...:.|||           :...:|.|.
Worm   327 AVGVSLSRCTELTVKHGGTKTSLHYWHPVFGHYLLPIDKRTEGALRNVLFQLKMLWSSRVVRCLF 391

  Fly   260 G---EHDKDEDSTQQVDEQSESAANATA----------TAESVESEAEPEEEDDD-----VCS-- 304
            |   |:.|.. |....|.|..|...:.|          :.:|..|.::.|.|...     ||.
Worm   392 GNIMENTKTA-SFSVTDGQKNSKDISAAFSKLWRKLGGSTDSASSSSKSESEPPPTLIAIVCQVY 455

  Fly   305 SQSSDTLVDLPGLRRVQRLLFG-CQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLA 368
            ..:.:|:|.:.|     .::.| |:...:.::|         |. |:| :|.          :.|
Worm   456 MTALNTMVHMKG-----EIISGLCRDDQLLKQL---------WT-YLR-EWG----------EKA 494

  Fly   369 TNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLD 433
            ..|:.|:.:....::..| :..:..::..|:....|.:          .|...|...|.  .:||
Worm   495 GGTSGSIFNSSNAEQWGP-VSASLQSLKRPSSPHTATL----------RLFVDCAAAII--SILD 546

  Fly   434 EESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLL 498
            ||.:.|.|:..|..::..|..|.||                                 |.:.|:.
Worm   547 EEEIFEKETPFSNKELESICKYVNI---------------------------------FCFRSIW 578

  Fly   499 EPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEI-GSGH 562
            .                 .|:|             |..:....:.|...|..|:..|.:. .|..
Worm   579 S-----------------GAVD-------------ETSANTTGLFHSMHSLLTVLYERDSRRSFA 613

  Fly   563 ANYFSFMLYAFILTPSTKVDALYYDSR-------MRMYSERYSSLHSILNNIGQVGQEDN----- 615
            ||...|.|.:.:...|..::   |:.:       ||..:........:|....||..:.|
Worm   614 ANDSKFWLISEVKPSSLTIE---YEKKSGKGVLMMRKMAHLVPIKDRMLLFRRQVQDDKNRVATS 675

  Fly   616 ---PRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVS-----KEFF 672
               |:....:||:|:::|.|   |...::......||..:.|:||.|||:||.|:.     |||.
Worm   676 LNDPQMQTWITVQRNRIIED---GFNHLSKLTIPALKSTIRVKFVNEQGLDEAGIDQDGVFKEFL 737

  Fly   673 QLIVEEIFNPAFGMFIQQEETNNMWFNATPF---ENGAQFTLIGIIIGLAIYNNVTLAVNFPMVV 734
            :|.::::|:|...:| ....|..::.:.|..   ::.|.||.:|.::|.|:|..:.:.|....|:
Worm   738 ELTLKKVFDPQLNLF-STTSTGVLYPSPTSSLHDDHLALFTFVGRMLGKAVYEGIVVDVQLAPVL 801

  Fly   735 YRKLIG---YCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVP 796
            ...::|   .| .|.:||...|.||:||..:..|:|:..:  ...||.:. .|..|.:...:|||
Worm   802 LAAVLGSHRLC-AFDELSQLDPELYRSLTFVKRYEGEMAD--LSLTFSVD-EDFMGKISTVDLVP 862

  Fly   797 NGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG-S 860
            :|:.:.|...||..:|:..:...:....::|..||..|.:.:...:.|. ||.|.:::.|:.| :
Worm   863 SGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQPTWLS-LFAPNDLQCLISGVN 926

  Fly   861 REFDFVELENSTVYEGGYTEKSQYIQDFWSIV-HAMPSEDKHKLLEFTTGSARVPVGG------- 917
            .:.|..:|:.:..|.||:....:.|:..|.|: :...||::...|:|.|..:|.||.|
Worm   927 SDIDLADLKRNVQYFGGFHGNHRLIKWLWDILENKFTSEERKLFLKFVTSCSRPPVLGFSYLEPP 991

  Fly   918 --LKCLRL-----------------LITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKA 963
              ::|:.:                 |..|.|..:.||||:.||||:|.||.|:.:..|.|:|..|
Worm   992 FSIRCVEVSDDQDQGDTLGSVVRGFLALRKGTAATRLPTASTCFNLLKLPNYNKKSLLLEKLRYA 1056

  Fly   964 INYSKGF 970
            |:...||
Worm  1057 IHAGTGF 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	109/390 (28%)
		HECTc	647..970	CDD:214523	101/361 (28%)
oxi-1	NP_499392.1	HECTc	684..1064	CDD:238033	109/389 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810