DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and etc-1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_495842.1	Gene:	etc-1 / 174388	WormBaseID:	WBGene00008429	Length:	1001	Species:	Caenorhabditis elegans

Alignment Length:	878	Identity:	195/878 - (22%)
Similarity:	320/878 - (36%)	Gaps:	296/878 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 SQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLAT 369
            |:|:...|::     ..|||     :.|...:|.  :..|::::|...|     |......:. |
Worm   205 SRSTSVSVNV-----ANRLL-----KTICVNITD--LNFSNYILYYIKD-----HIKPTSPNF-T 251

  Fly   370 NTNNSVVDMDYLD--RVLPKLCQAASAMPVPAQARLARIWAA---HCSDQLHSLIAACQQQITLQ 429
            |...::..:|.|:  :|.|::.:.||       .||..|:.:   |.|:.....:.  |...:|.
Worm   252 NLFEAMKSVDILNNWKVRPEIAETAS-------LRLQSIFVSQIVHVSNTQSEDVK--QYFNSLA 307

  Fly   430 VLLDEES-------MRENESII-----SVTKVLKIVFYANILASELERPSCRVPLEDRTEAATAS 482
            |.|:..|       ::|:.|..     ||...||......::::|..|.:|
Worm   308 VFLEHHSKIMRSLNVKEDLSEFGRLRTSVNNHLKQYCEEMLISNEFRRAAC-------------- 358

  Fly   483 GSAAVEDDLFVYNSL----------LEPHMPKF-----AEDQFEKEL-----------QVSAIDC 521
                      :|.:|          |..:..:|     |.:.|.:.|           :...||.
Worm   359 ----------IYANLPGVQVETIISLRKYFSQFLDLLAASNTFVEALYAFIARLCPNGEFDPIDA 413

  Fly   522 RKPLIPLEEFYNEALSENIQMHHD---------------------------YLSYKTLAMESEIG 559
            :.|.:...|.:...|::.:....|                           :|.:.|:| ..::.
Worm   414 KSPKVNALELFCNCLNKRVSSVADSDFVPTDIFVDFDHTVEFLRDVSIKLIHLMFPTMA-RGDLY 477

  Fly   560 SGH----------------ANYFSFMLYAFILTPSTKVDALYY-DSRMRMYSERYSSLH--SILN 605
            ||:                .:.||.:            .|:|. |.|::.:.|.:.:.|  .:|:
Worm   478 SGNLKEKMYKAETDWKDVTESVFSIL------------GAIYQKDIRLKYFPEEFWTNHGREVLS 530

  Fly   606 NIGQVGQ-----------------------------------------EDNPRPDL--------- 620
            .||:..:                                         |||..|.:
Worm   531 GIGEHRRMPRRRMPNGRLQIERTMDTEFVERLAAIYEMDSDSENDDEDEDNNLPAVLRRAICVMK 595

  Fly   621 --------------------------------------KLTVRRDQLINDALIGLEMVA--MSNP 645
                                                  .:||||||:..||   .|..|  |...
Worm   596 HIPFIVPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPSVTVRRDQVYMDA---FETFAPKMQGD 657

  Fly   646 K--DLKKQLVVEFV-----GEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNAT-P 702
            |  |||..:.|:.|     .|.|||.||:.:||...:::..||...| |....|:..::.|.| |
Worm   658 KVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAFNVERG-FFTFTESKLLYPNPTAP 721

  Fly   703 FENG----AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFAD---------LSDWSPA 754
            |..|    |.|..||.:||..||......|.|......::..     .|         :..:.|.
Worm   722 FLLGVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFE-----TDKNKDVDLQHMKSFDPI 781

  Fly   755 LYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFL 819
            ::|.||::.....::::|: :..|.:..||: |.|....|.|||....|...|...:|.||.::.
Worm   782 IFKHLKALQKMNNRELDEL-QLDFSVVTSDM-GLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYH 844

  Fly   820 LNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREF-------DFVELENSTVYEGG 877
            |...|....:|.|||...:.....:: :|.|.|:::::.|..|.       .|.||.    :..|
Worm   845 LKQRIASMVDAVRKGISEIISIEWMR-MFAPHELQIMIAGYEEVFTAKELRKFCELR----FAAG 904

  Fly   878 YTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHG----PDS-DRLPT 937
             |:...|.:.||.::..:.::||..||:|.||.:|.||.|.|.::   .|.|    |.| |.|||
Worm   905 -TQDINYEEMFWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQ---PRMGVLVIPSSDDELPT 965

  Fly   938 SHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            |.||.|:|.:|:||:|.||||:|..|||...||
Worm   966 SATCMNMLRIPKYSNRTKLEEKLRYAINSGAGF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	123/433 (28%)
		HECTc	647..970	CDD:214523	109/353 (31%)
etc-1	NP_495842.1	HECTc	661..998	CDD:214523	109/353 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810